Abstract 230 - IMPIEGO DEI GLICOPEPTIDI NELLA ... - SIMIT

228
10° CONGRESSO NAZIONALE SIMIT
Abstract 189
- PREVALENCE OF TYPE-2 DIABETES IN A POPULATION OF SARDINIAN
PATIENTS WITH CHRONIC HEPATITIS C WITHOUT CIRRHOSIS -
Chessa L.* [2] , Serra G. [2] , Balestrieri C. [2] , Conti M. [2] , Iovine M. [2] , Casu S. [2] , Cappellini S. [2] , Casale M. [2] ,
Pasetto M. C. [2] , Onali S. [2] , Figorilli F. [2] , Cossu E. [2] , Lai M. E. [2] , Farci P. [2]
- [2] Department of Medical Sciences - University of Cagliari ~ Cagliari
INFEZIONI DA VIRUS EPATITICI
Premessa: Several lines of evidence indicate an association between HCV infection and
glucose abnormalities, with more prevalence in advanced liver disease. Sardinia is an
island with a greater prevalence of HCV infection and type-2 diabetes compared to the
Italian mainland.
Obiettivo: The aim was to evaluate the prevalence of type-2 diabetes in Sardinian
patients with concomitant chronic hepatitis C, without cirrhosis. We studied a total of 516
consecutive patients with chronic hepatitis C (mean age 56.9±15 yrs, BMI 25.3±4.1,
47.5% males), seen between January 1, 2007 and January 31, 2008. We excluded
patients with cirrhosis, previous antiviral or steroid treatment, HIV or HBV coinfections,
with pancreatic, autoimmune or other liver diseases.
Risultati: We identified 60 patients (11.6%) with type-2 diabetes (CHC-T2DM), 112
patients (21.7%) with increased fasting glucose levels (CHC-IFG) and finally 344 patients
(66.7%) without any evidence of glucose abnormalities (CHC). CHC-T2DM were older
than CHC-IFG and CHC (68.1±10.5, 62±13, 53.1±14.8 yrs). Disease duration was longer
in CHC-T2DM (14.4±9.3 yrs) and in CHC-IFG (13.1±7.3 yrs) than in CHC (11.2±8.2 yrs).
There was a significant difference between CHC-T2D (48.3%), CHC-IFG (34.8%) and
CHC (17.2%) for a family history of type-2 diabetes (p=0,0001, p=0.0002). BMI and WC
were higher in CHC-DM than in IFG-CHC and CHC (p