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HBV'de Tedavi - EKMUD

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Asinetobakter Enfeksiyonları:<br />

<strong>Tedavi</strong><br />

dal sinerji gelişmektedir. A. baumannii’ye karşı<br />

bildirilen bu sinerji in vitro çalışmalarda gösterilmiştir.<br />

Beta-laktam ajanların kombinasyonu<br />

ile sinerji artışı gösterilmemiştir. Ancak, asinetobakter<br />

enfeksiyonlarının tedavisinde kombinasyon<br />

tedavisinin monoterapiden daha etkin<br />

olup olmadığı kesin değildir. Hastanın belirgin<br />

bir komorbiditesi yoksa monoterapi yeterli olabilir.<br />

Bakteriyofaj <strong>Tedavi</strong>si<br />

Son raporlar A. baumannii’nin faj tedavisine<br />

duyarlı olduğunu göstermektedir. Acinetobacter<br />

türlerine yönlendirilen bakteriyofaj, in vitro ve<br />

in vivo belirgin litik aktivite göstermektedir.<br />

Ancak ÇİD asinetobakter enfeksiyon tedavisine<br />

yönelik randomize, kontrollü çalışma bulunmadığı<br />

bilinmelidir.<br />

KAYNAKLAR<br />

1. Bassetti M, Righi E, Esposito S, et al. Drug treatment for<br />

multidrug-resistant Acinetobacter baumannii infections.<br />

Future Microbiol 2008;3:649-60.<br />

2. Bassetti M, Repetto E, Righi E, et al. Colistin and rifampicin<br />

in the treatment of multidrug-resistant Acinetobacter<br />

baumannii infections. J Antimicrob Chemother<br />

2008;61:417-20.<br />

3. Dauner DG, May JR, Steele JCH. Assessing antibiotic therapy<br />

for Acinetobacter baumannii infections in an academic<br />

medical center. Eur J Clin Microbiol Infect Dis<br />

2008;27:1021-4.<br />

266<br />

4. Falagas ME, Karveli EA, Siempos II. Acinetobacter infections:<br />

a growing threat for critically ill patients. Epidemiol<br />

Infect 2008;136:1009-19.<br />

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review of the evidence from old and recent studies.<br />

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of tigecycline disk diffusion susceptibility results for<br />

Acinetobacter spp. J Clin Microbiol 2007;45:227-30.<br />

7. Kallel H, Bahloul M, Hergafi L, et al. Colistin as a salvage<br />

therapy for nosocomial infections caused by multidrugresistant<br />

bacteria in the ICU. Int J Antimicrob Agents<br />

2006;28:366-9.<br />

8. Michalopoulos A, Falagas ME. Treatment of Acinetobacter<br />

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9. Michalopoulos A, Tsiodras S, Rellos K, et al. Effectiveness<br />

and safety of colistin treatment in patients with ICUacquired<br />

infections due to multiresistant gram-negative<br />

bacteria: the renaissance of an old antibiotic. Clin<br />

Microbiol Infect 2005;11:115-21.<br />

10. Murray CK, Hospenthal DR. Treatment of multidrug resistant<br />

Acinetobacter. Curr Opin Infect Dis 2005;18:502-6.<br />

11. Mushtaq S, Ge Y, Livermore DM. Comparative activities<br />

of doripenem versus isolates, mutants, and transconjugants<br />

of Enterobacteriaceae and Acinetobacter spp. with<br />

characterized beta-lactamases. Antimicrob Agents<br />

Chemother 2004;48:1313-9.<br />

12. Zhanel GG, DeCorby M, Nichol KA, et al. Antimicrobial<br />

susceptibility of 3931 organisms isolated from intensive<br />

care units in Canada: Canadian National Intensive Care<br />

Unit Study, 2005/2006. Diagn Microbiol Infect Dis<br />

2008;62:67-79.<br />

3. Türkiye <strong>EKMUD</strong> Bilimsel Platformu

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