Auditorium - Associazione Italiana di Epidemiologia

poster 9 settembre
EXPOSITION TO HIDROCARBONATE CLORATED PESTICIDES AND THE
RISK OF NON- HODGKIN LINFOMA
A. Arrieta Arroyo, F. Guillen Grima, I. Aguinaga Ontoso
Departamento de Ciencias de la Salud, Universidad Publica de Navarra. Pamplona. (Spain).
Introduction
Although farmers generally have low rates of morbidity and mortality, they appear to be
at excess of selected cancer. Some studies suggest that elevated risk of NHL among
farmers may be associated with exposure to pesticides and other agricultural chemicals.
To further evaluate this association the data from three population-based case-control
studies conducted in Iowa and Minnesota, Kansas and Nebraska were pooled to
evaluate the relationship between the use of chlorinated hydrocarbon insecticide and
Non-Hodgkin Lymphoma (NHL) among white male farmers.
Material and Methods
The data included 973 cases of non-Hodgkin’s lymphoma and 2853 populations-based
controls. Telephone or in-person interviews were conducted to obtain information on
the use of insecticides. Odds ratios (OR) adjusted for age at diagnosis, state of
residence, type of respondent, first-degree family history of cancer, use of hair dye and
tobacco smoking, as well as other insecticides or chemical classes were also adjusted
when assessing the risk of NHL associated with chlorinated hydrocarbon insecticide,
were estimated by conditional logistic regression.
Results
Use of Chlorinated Hydrocarbon Insecticides (CHI) in crops was associated with a
statistical significance 40% increased risk of NHL among those direct interview. The
risk increased with chlordane and Lindane use (OR = 1,63 y 1,59 respectively).
Conclusions: Although we found associations between the risk of NHL and specifics
CHI, larger risks from proxy respondents showed complicated data interpretation.
Association, however, between reported use of Chlordane and Lindane, particularly
among subjects providing direct interview was not easily discounted.
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