asistirana reproduktivna tehnologija u humanoj reprodukciji

S A D R @ A J
DEO I
ISTORIJAT ..................................................................................................... 3
DEO II
HUMANA REPRODUKCIJA ...................................................................21
A. REPRODUKCIJA ]ELIJE ........................................................................... 21
B. REPRODUKCIJA ORGANIZMA ................................................................ 23
1. GAMETOGENEZA ........................................................................................... 23
1.1. Oogeneza .................................................................................................24
11..11..11.. MMiittoozzaa ............................................................................................... 24
11..11..22.. MMeejjoozzaa ...............................................................................................26
11..11..33.. HHrroommoozzoommii uu ttookkuu mmeejjoottii~~kkee ddeeoobbee ...............................................30
11..11..44.. KKoommppeetteennttnnoosstt ii ssaazzrreevvaannjjee oooocciittaa ................................................. 34
11..11..55.. AAppooppttoozzaa }}eelliijjaa oovvaarriijjuummaa .............................................................. 41
1.2. Folikulogeneza .......................................................................................42
1.3. Interakcije oocit - granuloza ..................................................................44
1.4. Spermatogeneza ..................................................................................... 56
2. SPAJANJE GAMETA - OPLODNJA ................................................................... 57
2.1. Ovulacija ............................................................................................... 58
2.2. Transport oocita .................................................................................... 59
2.3. Cervikalni kanal u vreme ovulacije ...................................................... 60
2.4. Promene na spermatozoidu u toku oplodnje ........................................ 61
2.5. Formiranje ovuma ................................................................................. 64
2.6. Formiranje zigota ................................................................................... 64
2.7. Formiranje embriona ............................................................................. 66
2.8. Spontani hatching ................................................................................. 67
2.9. Migracija embriona kroz tubu .............................................................. 68
2.10. Genomski imprinting ............................................................................ 68
3. IMPLANTACIJA ........................................................................................... 77
3.1. Molekularni aspekti implantacije ......................................................... 86
4. EMBRIONALNI RAZVOJ ................................................................................ 89
XI