RATL: A Database of Reptile and Amphibian Toxicology Literature

Contaminant a Species
Code b
Lifestage Exposure
Route f
Table 4 - Laboratory Studies - 4
Study
Endpoint g Temp h pH Contaminant
Concentration
e
Results, Residues, Effects and/or Remarks d,e
Reference k
aldrin RATE adult TISPREP PHYSIO 18 Motor end plate: 10 -5 and 10 -4 exerted both pre- and postsynaptic
actions; caused increase in end-plate potential
frequency and decrease in their amplitude.
Akkermans et al. 1974 k
aldrin RATE adult TISPREP PHYSIO 18 Sartorious nerve-muscle 25 x 10 -5 M produced an increase in
end-plate potential to 4 times control levels at 20 min, after
which amplitude declined and transmission completely
blocked.
Akkermans et al. 1975b k
aldrin XELA adult TISPREP PHYSIO 19-21 Lateral-line organ: 25 x 10 -6 and 75 x 10 -6 M failed to induce
repetitive activity.
Akkermans et al. 1975a k
aldrin XELA adult TISPREP PHYSIO 10 Spinal cord: application of 1 x 10 -5 M in vitro caused
Akkermans et al. 1975c
potentiation of spinal reflex activity, increase in spontaneous
activity of ventral and dorsal roots and reduction of spinal
inhibitory mechanisms.
k
allethrin RAES adult TISPREP PHYSIO 10 -7 M Motor end plate: negative temp. coefficient.
Wouters et al. 1977 k
allethrin RAES adult TISPREP PHYSIO Peripheral nervous system studied.
van den Bercken 1977 k
allethrin RAPI adult TISPREP PHYSIO 22 10 -6 - 10 -4
Nerve muscle studied.
Takeno et al. 1977 k
allethrin RATE adult TISPREP PHYSIO 10 -7 M Motor end plate: negative temp. coefficient.
Wouters et al. 1977 k
allethrin RATE adult TISPREP PHYSIO Peripheral nervous system studied. van den Bercken et al. 1973a
k
allethrin XELA adult TISPREP PHYSIO 18 7.3 10 -5
1-4 end plate potentials and no repetitive activity with
respect to action potentials.
allethrin XELA adult IMMER BEHAV 5, 1 Excitation and convulsions within 10 min at 5 ppm.
Excitation at 1 ppm.
allethrin XELA adult TISPREP PHYSIO 2 Lateral line organ studied. Similarity between aldrin and DDT
noted.
Ruigt and Van den Bercken
1986
van den Bercken et al. 1973a
k
van den Bercken et al. 1973a
k
allethrin XELA adult TISPREP PHYSIO 15 2 x10 -5 M Myelinated fibre of sciatic nerve.
van den Bercken et al. 1980 k
allethrin XELA adult TISPREP PHYSIO Peripheral nervous system studied.
van den Bercken 1977 k
allethrin XELA adult TISPREP PHYSIO 20-24 0.33-3.3 x10 -
Pronounced repetitive activity in sensory fibres; similar van den Bercken and
6
M
results in cutaneous touch receptors and lateral line organ. Vijverberg 1979
allethrin XELA adult TISPREP PHYSIO Repetitive activity induced by 1-3 ppm for 20 - 40 min in
lateral line. Cutaneous touch receptors produced repetitive
activity after 5 min exposure to 10 -5 M or 15 min to 10 -6 M.
Akkermans et al. 1975a k
allethrin XELA adult TISPREP PHYSIO 15 10-40 µM Sodium channel gating and reduced selectively the rate of
closing of the activation gate in myelinated nerve fibre.
Vijverberg et al. 1982a