RATL: A Database of Reptile and Amphibian Toxicology Literature

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Table 5 - FETAX Studies - 18 Contaminant a Contaminant b Concentration b LC50 EC50 b TI d MCIG d NOEL d LOEL d Effects/Notes de Reference k rifampicin >0.2 mg/L >0.2 mg/L Unactivated rifampicin was not developmentally toxic at the limit of solubility in 1% DMSO. Bioactivation decreased the LC50 to 1400 mg/L. The EC50 for bioactivated rifampicin was 500 mg/L and the TI was 2.8. Fort et al. 1989 saccharin 14.68 - 14.13 - 0.9 - 1.1 13.33 - Bantle et al. 1994b 16.43 16.95 16.67 saccharin 17.94 - 18.2 - 0.95 - 12- 17 Dawson and Bantle 1987b 21.09 20.71 1.02 salicylaldehyde 10.8 mg/L 5.5 mg/L Schultz and Dawson 1995 mean mean salicylic acid 1067 476.4 Schultz and Dawson 1995 mg/L mg/L mean mean semicarbazide 10.8 mg/L At malformation inducing conc. levels: Dawson and Wilke 1991a hydrochloride (tested semicarbazide:isoniazid = Conc. additive, alone) TU=1.0. For embryo lethal conc. levels: semicarbazide:isoniazid = responseaddition (TU>1.0). semicarbazide Ratios of measured and calculated model Shirazi and Dawson 1991 hydrochloride parameters and median conc. ranged from 0.72 - 1.44 with an average of 0.99. semicarbazide 1504 76.28 TI (P): Dose dependent severity of bent and Snawder and Chambers 1989 hydrochloride (1052- (23.20- 19.7 wavy notochords. Some edema seen in a 2313) 125.8) few tadpoles. NAD+ reductions were dose dependent. (p= effect of abnormal pigmentation observed; g= effect of abnormal gut observed; n= abnormal notochord). serotonin Moderately strong teratogenic potential. DeYoung et al. 1991 sewage 10-50 µg/L 31.74 µg/L 10 µg/L 1.98 Sewage included Triton-16, an anionic detergent. Embryos showed axial abnormalities (6%) and 5% died. 10µg/L significantly reduced length. Presutti et al. 1994 sodium butyrate 379.2 mg/ Butyric acid:petanoic acid = conc. Dawson and Wilke 1991a L (tested alone) additive (TU=1.0).
Table 5 - FETAX Studies - 19 Contaminant a Contaminant b Concentration b LC50 EC50 b TI d MCIG d NOEL d LOEL d Effects/Notes de Reference k sodium butyrate 4.29 mL * For mixtures of valproic acid:butyric acid Dawson and Wilke 1991b valproic (3:1, 1:1, 1:3) the LC50s were 4.38 mL*, acid 4.21 mL* and 4.29 mL*. Mixture TUs for the same ratios were 1.01, 0.96 and 0.98, respectively. *(Of a total volume of 10 ml at 113.1 mg/L). sodium butyrate Ratios of measured and calculated model parameters and median conc. ranged from 0.72 - 1.44 with an average of 0.99. Shirazi and Dawson 1991 sodium cyclamate 12.16 - 12.17 - 1.0 - 1.3 10.00 - Bantle et al. 1994b 17.33 14.91 17.00 sodium cyclamate 15,930- 14480- 1.0-1.1 12,000 Dawson et al. 1989 16,340 15210 sodium selenate Moderately positive tertogenic potential. DeYoung et al. 1991 soil FETAX used to test a series of hazardous waste-site soil samples containing metals, PAHs and OPs. Samples collected from PAH and petroleum product-contained sites induced greater levels of embryolethal effects. Fort et al. 1995a solanidine Solanidine had no effect. Blankemeyer et al. 1992 0.075 In combination with BZH at conc. that Dawson 1993 ß-aminopropionitrile mg/L induce malformation: conc. additive at all (ßAPN) ratios (TU=1.0), this T.U occurred for all ratios (3:1, 1:1 and 1:3). ß-aminopropionitrile In binary combination of the 1:1 ratio Dawson et al. 1992 (ßAPN) mixture with valproic acid response addition occurred suggesting different modes of action for inducing malformation. Slight antagonism was observed for the 3:1 and 1:3 ratios. ß-aminopropionitrile 4.17 mL* The EC50s for ß-aminopropionitrile in Dawson and Wilke 1991b fumarate ratios of 3:1, 1:1 and 1:3) with isoniazid were 4.16mL*, 4.23mL* and 4.06mL*. The TUs for the mixture at each ratio were 1.00, 1.01 and 0.97, respectively. Strictly additive. *Of a total exposure volume of 10 ml at 0.137 mg/L. Concentrations were corrected for fumarate. ß-aminopropionitrile Ratios of measured and calculated model Shirazi and Dawson 1991 fumarate parameters and median conc. ranged from 0.72 - 1.44 with an average of 0.99.
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RATL: A Database of Reptile and Amp
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RATL: A Database of Reptile and Amp
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ABSTRACT Many amphibian and reptile
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PRÉFACE De nombreuses populations
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TABLE OF CONTENTS Abstract………
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LIST OF TABLES Table 1: Contaminant
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INTRODUCTION Why is there a need fo
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Limitations of RATL The RATL databa
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Contaminant a Species Code b Lifest
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Table 1- Field Residues - 20 Contam
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Table 2 - Field Studies - 2 Contami
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Table 2 - Field Studies - 12 Contam
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Table 3: Acute toxicity values from
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Contaminant a Species Code b azinph
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Contaminant a Species Code b tar XE
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Table 4: Laboratory studies not inc
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Contaminant a Species Code b Cd AMG
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Page 221 and 222: Contaminant a Species Code b Lifest
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Page 277 and 278: Table 6: pH study data. (Studies th
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Page 281 and 282: Species Code b Lifestage Study Endp
Page 289 and 290: Table 6 - pH Studies - 13 Species C
Page 317 and 318: Table 7: Reviews of primary literat
Page 319 and 320: Table 7 - Reviews - 3 Review Title
Page 321 and 322: Table 8 - Population Status - 2 Pop
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Table Notes Note a : see Appendix 2
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References - 2 Anderson, L.M. and R
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References - 4 Bantle, J.A., D.J. F
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References - 6 Beresford, W.A. , M.
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References - 8 Bishop, C.A, P. Ng,
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References - 10 Bragg, A.N. 1964. M
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References - 12 Burke, E.M. and F.H
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References - 14 Chattopadhyay, D.P.
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References - 16 Cooke, A.S. 1974. T
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References - 18 Dash, M.C. and A.K.
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References - 20 DeWitt, J.B., D.G.
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References - 22 Dutta, S.K. and P.
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References - 24 Elisyeyeva, K.H., H
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References - 26 Fontenot, L., C. Ro
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References - 28 Frisbie, M.P. and R
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References - 30 Godet, F., M. Babut
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References - 32 Gunther, R. and J.
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References - 34 Harfenist, A., T. P
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References - 36 Herkovits, J. and C
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References - 38 Hota, A. K. and M.C
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References - 40 Johnson, C.R. 1972a
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References - 42 Karns, D.R. 1984. T
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References - 44 Kraskowski, H.V., K
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References - 46 Leblanc, G.A. and L
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References - 48 Lotshaw, D.P. 1977.
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References - 50 Massot, M., J. Clob
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References - 52 Mendonca, M., J. Sh
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References - 54 Munro, D.F. 1949. E
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References - 56 Oliveira, E.M., D.V
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References - 58 Paulov, S. 1977b. T
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References - 60 Pierce, M.E. 1958.
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References - 62 Raj, T.P., A. Jeban
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References - 64 Rolfe, G. L., A. Ha
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References - 66 Sassaman, J.F. 1978
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References - 68 Semlitsch, R.D. and
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References - 70 Sparling, D.W., T.P
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References - 72 Surova, G.S. and A.
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References - 74 Tomar, V. and A. K.
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References - 76 Vijverberg, H.P.M.,
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References - 78 White, D.H. and A.J
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References - 80 Wyman, R.L. and J.
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Appendix 1a: Species codes in alpha
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Appendix 1a - Species Codes - 3 Cla
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Appendix 1a - Species Codes - 11 Cl
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Appendix 1a - Species Codes - 13 Cl
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Appendix 1b - Species Common Names
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Appendix 1c - Species Scientific Na
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Appendix 2a: Contaminant codes foun
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Appendix 2a - Contaminant Codes - 3
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Appendix 2b: Contaminants sorted by
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Appendix 2b - Contaminant Type - 3
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Appendix 4: Descriptions of exposur
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Appendix 6a: Glossary of Abbreviati
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Appendix 6b: Relevant biological an
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Appendix 6b - Glossary of RATL term
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RATL: A Database of Reptile and Amphibian Toxicology Literature

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