RATL: A Database of Reptile and Amphibian Toxicology Literature

Table 5 - FETAX Studies - 5
Contaminant a Contaminant
b
Concentration
b
LC50 EC50 b
TI d
MCIG d
NOEL d
LOEL d
Effects/Notes de
Reference k
caffeine 0.08 When coadministered with: hydroxyurea
(+), cytosine arabinoside (+),
cyclohexamide (+), emetine (+),
Fluorouracil (+)(+): increase in rate of
malformation compared to chemical
tested alone; (-): no significant difference
in rate of malformation.
Dawson and Bantle 1987a
carboxylic acids Overall treatment lethality for the study
was 0.43 %. The range of lethality for
the six combinations was 0.16 - 0.81 %.
For 1:0 and 0:1 solutions, mean
treatment lethality was 0.61 % while for
3:1, 1:1, and 1:3 treatments, the mean
lethality was 0.31 %.
Dawson 1994b
catechol 13.3 mg/L 2.7 mg/L
Schultz and Dawson 1995
mean mean
Cd 0.1-10 mg/L LC100 for 24 h was 1.13mg/L; LC100
for 72 h was 0.3 mg/L; malformations
and growth inhibitions did not appear to
be related to Cd toxicity.
Herkovits et al. 1997b
Cd 3.6 µmol/L At study termination (after 13 wks)
survival of Cd exposed was 51.1%.
Median number of days to
metamorphosis = 49 g (range: 41-85).
Mean body weight after 13 wks = 1.04 g
(SD=0.43).
Plowman et al. 1994
CdCl2, Cd 0.75-56 µmol/L 32 µmol/L 3.7 µmol/L 8.6 18
>95% of the embryos survived at 101 h Sunderman et al. 1991
Cd
µmol/L
post-fertilization, and the incidence of
malformations was = to or 95% of the embryos survived at 101 h Sunderman et al. 1992
Cd
µmol/L
post-fertilization, and the incidence of
malformations was = to or