RATL: A Database of Reptile and Amphibian Toxicology Literature

Contaminant a Species
Code b
Lifestage Exposure
Route f
Table 4 - Laboratory Studies - 19
Study
Endpoint g Temp h pH Contaminant
Concentration
e
Results, Residues, Effects and/or Remarks d,e
DDD CHPI adult ORAL RESIDUE 23-27 100 body wt 3, 6, 12, 24 h and 3 wks, respectively: Liver: 0.165, 0.070,
0.040, ND, 0.610. Brain: ND, 0.208, ND, ND, 1.502. Fat:
ND, ND, ND, ND, 5.295. Excrement: 0.002, 0.028, 0.143,
0.081, 0.083 (ppm).
DDD RAPI adult TISPREP PHYSIO 2 x10 -4 M Decrease in skin resistance and increase in short-circuit
current.
DDD TRSC adult ORAL RESIDUE 23-27 100 body wt 3, 6, 12, 24 h and 3 wks, respectively: Liver: 0.014, 0.204,
0.244, 0.141, 0.109. Brain: 3.166, 2.041, 2.333, ND,
17.194. Fat: ND, ND, ND, ND, 55.55. Excrement: 0.049,
0.041, 0.049, 0.048, 0.221.
DDD TRSC adult TISPREP PHYSIO 53, 106
and212 µM
Sig. inhibition of brain cell membranes and soluble and light
microsomes, as well as highly sig. inhibition of all other
fractions occurred at 212 µM.
Reference k
Owen and Wells 1976
Webb et al. 1979 k
Owen and Wells 1976
Witherspoon and Wells 1975
DDD TRSC adult (F) TISPREP PHYSIO Displaced estrogen at binding sites. Crain et al. 1998a
DDE ALMI adult TISPREP DEVOBS >50 IC50>50, inhibitor conc. necessary for 50% inhibition of
17ß-estradiol binding to estrogen receptor.
Vonier et al. 1996
DDE ALMI adult (F) TISPREP PHYSIO Displaced estrogen at binding sites. Crain et al. 1998a
DDE ALMI egg TISPREP DEVOBS DDE in combination with DDD in eggs interacted with 17ßestradiol
and reduced binding.
Vonier et al. 1996
DDE CHPI adult ORAL RESIDUE 23-27 100 body wt 3, 6, 12, 24 h and 3 wks, respectively: Liver: 0.064, 0.182,
0.163, 0.171, 0.786. Brain: ND, 0.277, ND, 0.179, 0.30. Fat:
1.084, 1.036, 2.553, 2.406, 6.576. Excrement: ND, ND<
0.001, 0.003, 0.018.
Owen and Wells 1976
DDE TRSC adult ORAL RESIDUE 23-27 100 body wt 3, 6, 12, 24 h and 3 wks, respectively: Liver: 0.256, 0.292,
0.361, 0.237, 0.230. Brain: 0.284, 0.423, 0.411, 0.007,
0.725. Fat: 7.682, 14.104, 9.003, 8.343, 7.580. Excrement:
0.001, 0.004, ND, 0.001, 0.038.
Owen and Wells 1976
DDE TRSC adult TISPREP PHYSIO 53, 106 and In vitro treatment with 212 µM resulted in inhibition of all Witherspoon and Wells 1975
212 µM cellular fractions of the brain. 106 µM had similar effects,
except in myelin and cell membranes, where little effect was
noted.
DDE TRSC adult (F) TISPREP PHYSIO Displaced estrogen at binding sites. Crain et al. 1998a
DDOH ALMI adult TISPREP DEVOBS 11.1 IC50= 11.1, inhibitor conc. necessary for 50% inhibition of
17ß-estradiol binding to estrogen receptor.
Vonier et al. 1996
DDT ACCR adult DERMAL MORT 21.1-
0.01- 0.05 Field observations following treatment suggested selective Boyd et al. 1963
23.9
g/mL pressures appeared sufficient to have forced expression of
resistant genotypes if present in the population.
DDT ACGR adult DERMAL MORT 21.1-
0.01- 0.05 Field observations following treatment suggested selective Boyd et al. 1963
23.9
g/mL pressures appeared sufficient to have forced expression of
resistant genotypes if present in the population.
DDT AGPI juvenile DERMAL PATH Behavioural abnormalities; recovery after 1 wk. Munro 1949