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RATL: A Database of Reptile and Amphibian Toxicology Literature

RATL: A Database of Reptile and Amphibian Toxicology Literature

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Contaminant a Species<br />

Code b<br />

Lifestage Exposure<br />

Route f<br />

Table 4 - Laboratory Studies - 27<br />

Study<br />

Endpoint g Temp h pH Contaminant<br />

Concentration<br />

e<br />

Results, Residues, Effects <strong>and</strong>/or Remarks d,e<br />

Reference k<br />

dieldrin RAPI tadpoles IMMER DEVOBS 22 0.0008- 0.6 µg/g (bioconc. factor= 690 ±190) at 0.0008 mg/L <strong>and</strong> 0.8 Schuytema et al. 1991<br />

0.0021 mg/L µg/g (bioconc. factor= 390 ±40) at 0.0021 mg/L.<br />

dieldrin RAPI tadpoles IMMER MORT < 0.0001- Mortality increased with conc. <strong>and</strong> time: 52.5% at 0.0101 Schuytema et al. 1991<br />

0.0261 mg/L mg/L, 100% at 0.0261 mg/L. Survivors at higher conc. were<br />

larger than controls.<br />

dieldrin RATE adult TISPREP PHYSIO 10 -5 - 10 -4 M No sig. effect on frequency <strong>and</strong> amplitude <strong>of</strong> end-plate<br />

potentials, or on end-plate membrane potential.<br />

Akkermans et al. 1974 k<br />

dieldrin RATE tadpoles IMMER RESIDUE 0.0008- 0.5 0.17 - 42.9 ppm (24-48h).<br />

Cooke 1972b k<br />

dieldrin RATE tadpoles IMMER BEHAV 0.02- 0.5 0.5 produced 5 % mortality <strong>and</strong> abnormal behaviour after 24<br />

h, 47% mortality after 48 h. Snout abnormalities noted. 0.02<br />

ppm had no effect.<br />

Cooke 1972b k<br />

dieldrin TRSC adult INJECT RESIDUE 28 20 Rate <strong>of</strong> absorption in tissue after injection was slow <strong>and</strong><br />

erratic; Residues: Body fat 445-1329 > Liver 46-117 ><br />

Kidney 13-59 > Brain 8-27 > Muscle 4-7 > Plasma 3-7.<br />

Values are ranges in tissue after 70d.<br />

Pearson et al. 1973<br />

dieldrin XELA adult TISPREP PHYSIO 10 0-5 x10 -5 M Application failed to produce any sig. effects in spinal cord. Akkermans et al. 1975c k<br />

dieldrin XELA adult IMMER PHYSIO 1 Dieldrin treated frogs showed sig. levels <strong>of</strong> vitellogenin<br />

induction.<br />

Palmer et al. 1998<br />

dieldrin XELA adult TISPREP PHYSIO Increase in amplitude <strong>of</strong> negative after-potential; slowing <strong>of</strong><br />

falling phase <strong>of</strong> action potential; no effect on resting<br />

potential; no repetitive activity.<br />

van den Bercken et al. 1973b<br />

dieldrin XELA adult TISPREP PHYSIO 5 x10 -4 M, 3-5 Preparation taken from animals showing severe symptoms <strong>of</strong><br />

Akkermans et al. 1975a<br />

poisoning after exposure to 3-5 ppm.<br />

k<br />

dieldrin XELA juvenile IMMER MORT 0.0021 mg/L Results not extracted from paper. Schuytema et al. 1991<br />

dieldrin XELA tadpoles IMMER DEVOBS 075-6.0 ppb Highest dieldrin conc. retarded development. Bl<strong>and</strong>in <strong>and</strong> Ramsdell 1995<br />

dieldrin XELA tadpoles IMMER MORT

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