RATL: A Database of Reptile and Amphibian Toxicology Literature

Contaminant a Contaminant
b
Concentration
b
LC50
paraquat 0-10.0 mg/L 8.1, 4.2,
3.2 mg/L
parathion 14.7
(13.5-
16.0)
EC50 b
mean
P=0.33;
G=0.46
TI d
TI (P):
44.6; TI
(G): 32.0;
TI (N):
2.7
Table 5 - FETAX Studies - 16
MCIG d
NOEL d
LOEL d
Effects/Notes de
For the formulation product LC50 values
were (mg/L): >8.1 (96h), 6.2 (10d), 6.2
(30d).
Significantly decreased growth. 10-fold
less potent than metabolite paraoxon.
Minimal curvature to severe notochordal
bending. Barrel-shaped embryos. (p=
effect of abnormal pigmentation
observed; g= effect of abnormal gut
observed; n= abnormal notochord).
Pb 0.02-3.0 mg/L Short-term effects: no Pb uptake in
tissues between 72 and 96 h. 0.02-0.1
µg/L conc. treatments after 3 weeks
displayed delayed lordoscolosis
(dorsal/ventral and lateral flexure of the
tail).
Pb acetate 0 - > 1 mg/L Lethality and/or abnormalities occurred
above 1 mg/L.
PCB 126 17.1 pmol/mL -
15.5 µmol/mL
PCB 126 17.1 pmol/mL -
15.5 µmol/mL
Reference k
Linder et al. 1990
Snawder and Chambers 1989
Sobotka and Rahwan 1995
Kanunura and Tanimura
1985 k
Larvae; 29% of the animals died within
first 10 days, 48% died over whole
experimental period. 93% of animals
were malformed when exposed to 6.4
µmol/mL of PCB 126. Oedema,
misformed eyes, tails and lack of gut
coiling were most common
malformations.
Gutleb et al. 1998
No effect on rate of
malformations,growth and development
in FETAX assay.
Gutleb et al. 1998
7.8 - 9.2 0.01 Metal contaminated soils also tested. Fort et al. 1995b
pentachlorophenol 0.39 - 0.03 -
0.46 0.05
pentachlorophenol 0.52 - 0.07 - 5.6 - 7.43 0.15 -
Conc. as low as 0.5 µg/L inhibited tail Fort and Stover 1996
0.56 0.10
0.18
resorption.
pentachlorophenol 0.5-25.0 µg/L 5.0 10.0 Stage 60-66 embryo. Fort and Stover 1997
pentanoic acid 183.6-
Valproic acid:petanoic acid and butyric Dawson and Wilke 1991a
274-5
acid:petanoic acid = conc. additive
mg/L
(TU=1.0).
pentanoic acid 0-360.0 mg/L 227.7
EC50 in mixture: 23.2 (21.6-24.8) TU in Dawson 1991
(216.0-
mixture for malformation: 0.102 (0.095-
238.5)
0.109).