RATL: A Database of Reptile and Amphibian Toxicology Literature

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Contaminant a Contaminant b Concentration b LC50 acetaminophen decreased 3.9 EC50 b decreased 7.1 TI d Table 5 - FETAX Studies - 2 MCIG d NOEL d LOEL d Effects/Notes de Results indicate that a highly reactive intermediate formed as the result of MFO-mediated metabolism (possibly P- 448) significantly increased the developmental toxicity of acetaminophen. Reference k Fort et al. 1992 acetone 1.92 - 2.49 1.06 - 1.4 1.6 - 1.83 1.0 - 1.8 Results from 3 trials. Rayburn et al. 1991b acetone 0.9-1.0% v/v 0.9% v/v Acetone increased the mortality for both teratogens, but only increased the methylmercury chloride malformation greater than the additive effects. There were additive effects for growth for all solvents with the teratogens. EC25(96) = 1.0%v/v. Rayburn et al. 1991a acridine 3.6 (LC48=10 midblastula embryo: Abnormalities included exogastrulation, edema, formation of blisters. Davis et al. 1981 .9; 48h = 65; LC72=8.7 72h = 26; mg/L 96h = 24 k acridine 5.0 mg/L Max conc. in larvae = 85 ppm; ND after 2 h. Davis et al. 1981 k actinomycin D 18.9 21.7 15.9 EC50 (96 h) for swimming ability = 17.6 Courchesne and Bantle 1985 (13.8- (18.8- mg/L (0.08-38.0) mg/L. EC50 (96 h) for 26.1)mg/L 25.1)mg/L pigmentation = 21.8 (16.8-28.1) mg/L. Min conc. to inhibit development = 15.9 mg/L. AH (acetylhydrazide) decreased increased decreased Fluctuations with contaminant-induced Fort and Bantle 1990a 7.9 fold 2.0 fold 15.87 fold metabolic activation. AH (acetylhydrazide) 1.0-50.0 mg/L Embryo stage 46-54; abnormal hind limb development >25.0mg/L. Fort and Stover 1997 alcohol All aceylenic alcohols tested produced linear conc.-response relationships for embryolethality, embryo malformation and 5 d old tadpole lethality. Primary propargylic alcohols were teratogenic, producing head, eye, gut, and skeletal malformations in larvae/tadpole. Dawson et al. 1990 alpha-chaconine 2.03 ± Alpha-chaconine increased dye Blankemeyer et al. 1992 0.005 mg/L. fluoresence up to 1600% of control.
Table 5 - FETAX Studies - 3 Contaminant a Contaminant b Concentration b LC50 EC50 b TI d MCIG d NOEL d LOEL d Effects/Notes de Reference k alpha-chaconine 0.0022 0.0020 1.1 6mg/L L / >1.05 3.7/>6 and with MAS respectively. alpha-solanine 8.3 ±0.03 Alpha-solanine increased dye Blankemeyer et al. 1992 mg/L. fluorescence up to 400% of control. alpha-solanine 0.0297 0.0131 2.26 Results given for solanine without MAS Friedman et al. 1991 / > 20 19.9 /> 1.0 20 and with MAS respectively. amaranth 2670- 3060- 0.8 - 1.2 3750- Bantle et al. 1990 3810 3910 4000 aniline 550; LC24 mid = 1400; blastula Abnormalities included exogastrulation, edema, formation of blisters. Davis et al. 1981 LC48 = stage 24 h 660; LC72 = 360 = 490 m/L; 48 h = 560 mg/L; 72 h = 460 mg/L; 96 h = 370 mg/L k Aroclor 1254 1.1nmol/mL- 64.4 Depigmentation occurred in animals yet Gutleb et al. 1998 1.2mmol/mL µmol/mL no effect on rate of malformation or growth and development was otherwise noted at any of the treatment conc. aromatic petroleum crude 33 - 38 % 31.1 % Dumont et al. 1983 k ascorbic acid Little to no teratogenic potential. DeYoung et al. 1991 aspartame > 10000 - 13140 1.1 3000- Bantle et al. 1990 13920 7000 atrazine 100 mg/L 33 mg/L in 3.03 in 1.1 mg/L In natural water LC50=126 mg/L, Morgan et al. 1996 in buffer buffer buffer EC501.3 mg/L
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RATL: A Database of Reptile and Amp
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RATL: A Database of Reptile and Amp
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ABSTRACT Many amphibian and reptile
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PRÉFACE De nombreuses populations
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TABLE OF CONTENTS Abstract………
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LIST OF TABLES Table 1: Contaminant
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INTRODUCTION Why is there a need fo
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Limitations of RATL The RATL databa
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Contaminant a Species Code b Lifest
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Table 1- Field Residues - 20 Contam
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Table 2 - Field Studies - 2 Contami
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Table 2 - Field Studies - 12 Contam
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Table 3: Acute toxicity values from
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Contaminant a Species Code b azinph
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Contaminant a Species Code b tar XE
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Table 4: Laboratory studies not inc
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Contaminant a Species Code b Cd AMG
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Page 205 and 206: Contaminant a Species Code b Lifest
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Page 261 and 262: Contaminant a Contaminant b Concent
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Page 277 and 278: Table 6: pH study data. (Studies th
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Page 281 and 282: Species Code b Lifestage Study Endp
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Table 6 - pH Studies - 31 Species C
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Species Code b Lifestage Study Endp
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Table 7: Reviews of primary literat
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Table 7 - Reviews - 3 Review Title
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Table 8 - Population Status - 2 Pop
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Table Notes Note a : see Appendix 2
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References - 2 Anderson, L.M. and R
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References - 4 Bantle, J.A., D.J. F
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References - 6 Beresford, W.A. , M.
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References - 8 Bishop, C.A, P. Ng,
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References - 10 Bragg, A.N. 1964. M
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References - 12 Burke, E.M. and F.H
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References - 14 Chattopadhyay, D.P.
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References - 16 Cooke, A.S. 1974. T
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References - 18 Dash, M.C. and A.K.
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References - 20 DeWitt, J.B., D.G.
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References - 22 Dutta, S.K. and P.
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References - 24 Elisyeyeva, K.H., H
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References - 26 Fontenot, L., C. Ro
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References - 28 Frisbie, M.P. and R
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References - 30 Godet, F., M. Babut
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References - 32 Gunther, R. and J.
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References - 34 Harfenist, A., T. P
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References - 36 Herkovits, J. and C
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References - 38 Hota, A. K. and M.C
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References - 40 Johnson, C.R. 1972a
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References - 42 Karns, D.R. 1984. T
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References - 44 Kraskowski, H.V., K
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References - 46 Leblanc, G.A. and L
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References - 48 Lotshaw, D.P. 1977.
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References - 50 Massot, M., J. Clob
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References - 52 Mendonca, M., J. Sh
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References - 54 Munro, D.F. 1949. E
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References - 56 Oliveira, E.M., D.V
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References - 58 Paulov, S. 1977b. T
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References - 60 Pierce, M.E. 1958.
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References - 62 Raj, T.P., A. Jeban
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References - 64 Rolfe, G. L., A. Ha
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References - 66 Sassaman, J.F. 1978
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References - 68 Semlitsch, R.D. and
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References - 70 Sparling, D.W., T.P
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References - 72 Surova, G.S. and A.
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References - 74 Tomar, V. and A. K.
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References - 76 Vijverberg, H.P.M.,
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References - 78 White, D.H. and A.J
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References - 80 Wyman, R.L. and J.
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Appendix 1a: Species codes in alpha
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Appendix 1a - Species Codes - 3 Cla
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Appendix 1a - Species Codes - 11 Cl
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Appendix 1a - Species Codes - 13 Cl
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Appendix 1b - Species Common Names
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Appendix 1c - Species Scientific Na
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Appendix 2a: Contaminant codes foun
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Appendix 2a - Contaminant Codes - 3
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Appendix 2b: Contaminants sorted by
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Appendix 2b - Contaminant Type - 3
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Appendix 4: Descriptions of exposur
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Appendix 6a: Glossary of Abbreviati
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Appendix 6b: Relevant biological an
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Appendix 6b - Glossary of RATL term
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RATL: A Database of Reptile and Amphibian Toxicology Literature

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