RATL: A Database of Reptile and Amphibian Toxicology Literature

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Contaminant a Contaminant b Concentration b LC50 paraquat 0-10.0 mg/L 8.1, 4.2, 3.2 mg/L parathion 14.7 (13.5- 16.0) EC50 b mean P=0.33; G=0.46 TI d TI (P): 44.6; TI (G): 32.0; TI (N): 2.7 Table 5 - FETAX Studies - 16 MCIG d NOEL d LOEL d Effects/Notes de For the formulation product LC50 values were (mg/L): >8.1 (96h), 6.2 (10d), 6.2 (30d). Significantly decreased growth. 10-fold less potent than metabolite paraoxon. Minimal curvature to severe notochordal bending. Barrel-shaped embryos. (p= effect of abnormal pigmentation observed; g= effect of abnormal gut observed; n= abnormal notochord). Pb 0.02-3.0 mg/L Short-term effects: no Pb uptake in tissues between 72 and 96 h. 0.02-0.1 µg/L conc. treatments after 3 weeks displayed delayed lordoscolosis (dorsal/ventral and lateral flexure of the tail). Pb acetate 0 - > 1 mg/L Lethality and/or abnormalities occurred above 1 mg/L. PCB 126 17.1 pmol/mL - 15.5 µmol/mL PCB 126 17.1 pmol/mL - 15.5 µmol/mL Reference k Linder et al. 1990 Snawder and Chambers 1989 Sobotka and Rahwan 1995 Kanunura and Tanimura 1985 k Larvae; 29% of the animals died within first 10 days, 48% died over whole experimental period. 93% of animals were malformed when exposed to 6.4 µmol/mL of PCB 126. Oedema, misformed eyes, tails and lack of gut coiling were most common malformations. Gutleb et al. 1998 No effect on rate of malformations,growth and development in FETAX assay. Gutleb et al. 1998 7.8 - 9.2 0.01 Metal contaminated soils also tested. Fort et al. 1995b pentachlorophenol 0.39 - 0.03 - 0.46 0.05 pentachlorophenol 0.52 - 0.07 - 5.6 - 7.43 0.15 - Conc. as low as 0.5 µg/L inhibited tail Fort and Stover 1996 0.56 0.10 0.18 resorption. pentachlorophenol 0.5-25.0 µg/L 5.0 10.0 Stage 60-66 embryo. Fort and Stover 1997 pentanoic acid 183.6- Valproic acid:petanoic acid and butyric Dawson and Wilke 1991a 274-5 acid:petanoic acid = conc. additive mg/L (TU=1.0). pentanoic acid 0-360.0 mg/L 227.7 EC50 in mixture: 23.2 (21.6-24.8) TU in Dawson 1991 (216.0- mixture for malformation: 0.102 (0.095- 238.5) 0.109).
Contaminant a Contaminant b Concentration b LC50 pentanoic acid 183.6-274-5 mg/L pH, Cu 0.042-1.18 mg/L EC50 b TI d Table 5 - FETAX Studies - 17 MCIG d NOEL d LOEL d Effects/Notes de In binary combination with valproic acid conc. addition occurred suggesting similar modes of action. Mortality related to copper. Over all pH treatments, interactions between fulvic acid and pH were associated with fulvic acid and copper activity. Reference k Dawson et al. 1992 Buchwalter et al. 1996 phenol 2.5 mg/L 13 mg/L LC10=1.56 mg/L. Bernardini et al. 1996 propionic acid 0-2000.0 mg/L 1514.0 EC50 in mixture: 103.0 (96.0-110.0) TU Dawson 1991 (1360- in mixture for malformation: 0.068 1700) (0.063-0.073). pseudoephedrine 390-440 210-260 1.7 - 1.9 150 - 200 Bantle et al. 1990 purification system water Input water 100 % mortality; output water 6.7 % mortality. Common malformations observed were abnormal spine, gut and eyes. Vismara et al. 1993 quinaldine 26.4 Development retarded, reduction in motility; early cleavage to mid blastula stage. Dumont et al. 1979 k quinaldine 6.5 Reduced mortality, development retarded, Dumont et al. 1979 pigmentation lighter. k quinoline 26.3 Caused reduced motility and retarded development. Dumont et al. 1979 k quinoline 79; LC24 = 219; 24 h = 71; 72 h = 36; Davis et al. 1981 LC48 = 115; LC72 = 87 96 h = 29 k retinoic acid 0.0056- Isoniazid: retinoic acid, Dawson and Wilke 1991a 0.0059 hydroxyurea:retinoic acid, and 6- mg/L aminonicotinamide:retinoic acid = (tested alone) response-additive (TU> 1.0). retinoic acid In binary combination with valproic acid response addition occurred suggesting different modes of action for inducing malformation. Dawson et al. 1992 retinoic acid Strong tertatogenic potential. DeYoung et al. 1991 retinoic acid 0.25 - 0.5 0.024 - 10.4 - 0.06 - Results of 3 trials. Rayburn et al. 1991b 0.44 11.4 0.08
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RATL: A Database of Reptile and Amp
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RATL: A Database of Reptile and Amp
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ABSTRACT Many amphibian and reptile
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PRÉFACE De nombreuses populations
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TABLE OF CONTENTS Abstract………
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LIST OF TABLES Table 1: Contaminant
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INTRODUCTION Why is there a need fo
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Limitations of RATL The RATL databa
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Contaminant a Species Code b Lifest
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Table 1- Field Residues - 20 Contam
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Table 2 - Field Studies - 2 Contami
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Table 2 - Field Studies - 12 Contam
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Table 3: Acute toxicity values from
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Contaminant a Species Code b azinph
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Contaminant a Species Code b tar XE
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Table 4: Laboratory studies not inc
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Contaminant a Species Code b Cd AMG
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Page 219 and 220: Contaminant a Species Code b Lifest
Page 255 and 256: Table 5: FETAX data. [FETAX (Frog E
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Page 261 and 262: Contaminant a Contaminant b Concent
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Page 277 and 278: Table 6: pH study data. (Studies th
Page 279 and 280: Table 6 - pH Studies - 3 Species Co
Page 281 and 282: Species Code b Lifestage Study Endp
Page 289 and 290: Table 6 - pH Studies - 13 Species C
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Table 8 - Population Status - 2 Pop
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Table Notes Note a : see Appendix 2
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References - 2 Anderson, L.M. and R
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References - 4 Bantle, J.A., D.J. F
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References - 6 Beresford, W.A. , M.
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References - 8 Bishop, C.A, P. Ng,
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References - 10 Bragg, A.N. 1964. M
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References - 12 Burke, E.M. and F.H
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References - 14 Chattopadhyay, D.P.
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References - 16 Cooke, A.S. 1974. T
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References - 18 Dash, M.C. and A.K.
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References - 20 DeWitt, J.B., D.G.
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References - 22 Dutta, S.K. and P.
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References - 24 Elisyeyeva, K.H., H
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References - 26 Fontenot, L., C. Ro
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References - 28 Frisbie, M.P. and R
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References - 30 Godet, F., M. Babut
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References - 32 Gunther, R. and J.
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References - 34 Harfenist, A., T. P
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References - 36 Herkovits, J. and C
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References - 38 Hota, A. K. and M.C
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References - 40 Johnson, C.R. 1972a
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References - 42 Karns, D.R. 1984. T
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References - 44 Kraskowski, H.V., K
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References - 46 Leblanc, G.A. and L
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References - 48 Lotshaw, D.P. 1977.
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References - 50 Massot, M., J. Clob
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References - 52 Mendonca, M., J. Sh
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References - 54 Munro, D.F. 1949. E
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References - 56 Oliveira, E.M., D.V
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References - 58 Paulov, S. 1977b. T
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References - 60 Pierce, M.E. 1958.
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References - 62 Raj, T.P., A. Jeban
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References - 64 Rolfe, G. L., A. Ha
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References - 66 Sassaman, J.F. 1978
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References - 68 Semlitsch, R.D. and
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References - 70 Sparling, D.W., T.P
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References - 72 Surova, G.S. and A.
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References - 74 Tomar, V. and A. K.
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References - 76 Vijverberg, H.P.M.,
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References - 78 White, D.H. and A.J
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References - 80 Wyman, R.L. and J.
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Appendix 1a: Species codes in alpha
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Appendix 1a - Species Codes - 3 Cla
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Appendix 1a - Species Codes - 11 Cl
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Appendix 1a - Species Codes - 13 Cl
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Appendix 1b - Species Common Names
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Appendix 1c - Species Scientific Na
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Appendix 2a: Contaminant codes foun
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Appendix 2a - Contaminant Codes - 3
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Appendix 2b: Contaminants sorted by
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Appendix 2b - Contaminant Type - 3
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Appendix 4: Descriptions of exposur
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Appendix 6a: Glossary of Abbreviati
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Appendix 6b: Relevant biological an
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Appendix 6b - Glossary of RATL term
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RATL: A Database of Reptile and Amphibian Toxicology Literature

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