RATL: A Database of Reptile and Amphibian Toxicology Literature

Table 5 - FETAX Studies - 19
Contaminant a Contaminant
b
Concentration
b
LC50 EC50 b
TI d
MCIG d
NOEL d
LOEL d
Effects/Notes de
Reference k
sodium butyrate 4.29 mL *
For mixtures of valproic acid:butyric acid Dawson and Wilke 1991b
valproic
(3:1, 1:1, 1:3) the LC50s were 4.38 mL*,
acid
4.21 mL* and 4.29 mL*. Mixture TUs
for the same ratios were 1.01, 0.96 and
0.98, respectively. *(Of a total volume
of 10 ml at 113.1 mg/L).
sodium butyrate Ratios of measured and calculated model
parameters and median conc. ranged from
0.72 - 1.44 with an average of 0.99.
Shirazi and Dawson 1991
sodium cyclamate 12.16 - 12.17 - 1.0 - 1.3 10.00 -
Bantle et al. 1994b
17.33 14.91
17.00
sodium cyclamate 15,930- 14480- 1.0-1.1 12,000 Dawson et al. 1989
16,340 15210
sodium selenate Moderately positive tertogenic potential. DeYoung et al. 1991
soil FETAX used to test a series of hazardous
waste-site soil samples containing metals,
PAHs and OPs. Samples collected from
PAH and petroleum product-contained
sites induced greater levels of
embryolethal effects.
Fort et al. 1995a
solanidine Solanidine had no effect. Blankemeyer et al. 1992
0.075
In combination with BZH at conc. that Dawson 1993
ß-aminopropionitrile
mg/L
induce malformation: conc. additive at all
(ßAPN)
ratios (TU=1.0), this T.U occurred for all
ratios (3:1, 1:1 and 1:3).
ß-aminopropionitrile
In binary combination of the 1:1 ratio Dawson et al. 1992
(ßAPN)
mixture with valproic acid response
addition occurred suggesting different
modes of action for inducing
malformation. Slight antagonism was
observed for the 3:1 and 1:3 ratios.
ß-aminopropionitrile
4.17 mL* The EC50s for ß-aminopropionitrile in Dawson and Wilke 1991b
fumarate
ratios of 3:1, 1:1 and 1:3) with isoniazid
were 4.16mL*, 4.23mL* and 4.06mL*.
The TUs for the mixture at each ratio
were 1.00, 1.01 and 0.97, respectively.
Strictly additive. *Of a total exposure
volume of 10 ml at 0.137 mg/L.
Concentrations were corrected for
fumarate.
ß-aminopropionitrile
Ratios of measured and calculated model Shirazi and Dawson 1991
fumarate
parameters and median conc. ranged from
0.72 - 1.44 with an average of 0.99.