RATL: A Database of Reptile and Amphibian Toxicology Literature

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Contaminant a Contaminant b Concentration b LC50 fluoranthene, UV 0, 25, 125, 250, 625 µg/L fluoranthene, UV 0, 25, 125, 250, 625 µg/L EC50 b TI d Table 5 - FETAX Studies - 10 MCIG d NOEL d LOEL d Effects/Notes de UV exposure alone cause brown pigmentation on skin. UV + PAH exposure resulted in inhibited growth and 40% mortality at 125 µg/L of fluoranthene and 100% mortality at 1250 µg/L of fluoranthene. UV exposure alone caused brown pigmentation on skin. UV + PAH exposure resulted in inhibited growth and 40% mortality at 125 µg/L of fluoranthene and 100% mortality at 1250 µg/L of fluoranthene. fluorouracil 0.53 mg/L 0.08 6.63 Malformations included abnormal gut, face, eye, brain, heart, spine formation (0.01 mg/L). fluorouracil 0.71 - 1.9 0.038 - 6.7 - 18.7 0.05 - 0.122 0.125 fluorouracil 1.22 - 0.120 - 10.16 - 0.0875 - 1.62 0.137 11.82 0.120 fluorouracil 0.08 mg/mL Tested alone at this conc. Fuorouracil exhibited 24% malformation in survivors (1.9% mortality). Coadministration of caffeine, theophylline, and theobromine greatly increased the incidence of malformed embryos (85.7%, 87.8% and 42.5% respectively). formamide 0.25-1.75% v/v 1.04% v/v (pooled trials) 1.26, 0.83,0.97 1.06% v/v (trials (trials separate) separate) 0.75, 0.5% v/v (trials separate) Most toxic solvent. NOEL values for mortality and length were: 1.0, 0.5% v/v (mortality), 0.75, 1.0% v/v (length). Reference k Hatch & Burton 1996 Hatch & Burton 1998 DeYoung et al. 1996 Bantle et al. 1994b Dawson and Bantle 1987b Dawson and Bantle 1987a Dresser et al. 1992 fuel oil blend 1.48 % 0.96 % Dumont et al. 1983 k Garlon 3A 100 mg/L No significant effects up to 100 mg/L for formulated triclopyr. Perkins 1995 gentisic acid 10839.5 1531.8 Schultz and Dawson 1995 mg/L mg/L mean mean glycerol formal 0.25-1.75% v/v 1.65, 1.09, 1.51,1.37 0.50% v/v NOEL values for mortality and length Dresser et al. 1992 1.57% v/v 1.15% v/v (malform.) were: 1.25, 1.0% v/v (mortality) and 0.75,
Table 5 - FETAX Studies - 11 Contaminant a Contaminant b Concentration b LC50 EC50 b TI d MCIG d NOEL d LOEL d Effects/Notes de Reference k glyphosate salt without surfactant (Rodeo) 5000 mg/L No significant effects on XELA. Perkins 1995 groundwater 36.3 - > 21.2 > 100 1.7 - 2.2 Bantle et al. 1989a 100 % % heptanoic acid 0-88 mg/L 57.6 EC50 in mixture: 5.7 (5.3-6.1) TU in Dawson 1991 (55.0- mixture for malformation: 0.099 (0.092- 60.5) 0.106). hexanoic acid 0-176.4 mg/L 108.1 EC50 in mixture: 9.1 (8.5-9.7) TU in Dawson 1991 (102.3- mixture for malformation: 0.084 (0.079- 114.7) 0.090). hydrazine blastula to hatching = 114 - 125 mg/L Greenhouse 1977 k hydroxyurea 187.2 At malformation inducing conc. levels: Dawson and Wilke 1991a mg/L hydroxyurea:isoniazid and (tested hydroxyurea:retinoic acid = response- alone) addition (TU= 1.0). hydroxyurea In binary combination with valproic acid response addition occurred suggesting different modes of action for inducing malformation. Dawson et al. 1992 hydroxyurea Ratios of measured and calculated model parameters and median conc. ranged from 0.72 - 1.44 with an average of 0.99. Shirazi and Dawson 1991 hydroxyurea 0.75 0.18 4.2 0.25 Bantle et al. 1994a hydroxyurea 1820 (1.5- 430 (0.35- 300 mg/L The slope of the dose-response curve for Courchesne and Bantle 1985 2.7) mg/L 0.5) mg/L malformation did not change but the entire curve was shifted to lower conc. throughout the course of the experiment. The greater shift occurred between 24 and 48 h into the experiment. hydroxyurea 0.3 mg/mL Hydroxyurea alone caused 20.6 % malformation. Coadministration with caffeine or theophylline greatly increased the incidence of malformed embryos (89% and 50.6%, respectively) and mortality (6.9% and 8.1%, respectively). Dawson and Bantle 1987a imidacloprid 17.4 mg/L 10 mg/L Tadpole. Channing 1998 INA 2.5 None of MAS affected developmental toxicity of INA. Fort and Bantle 1990a isazophos 724 mg/L 0.25 mg/L Tadpole. Channing 1998
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RATL: A Database of Reptile and Amp
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RATL: A Database of Reptile and Amp
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ABSTRACT Many amphibian and reptile
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PRÉFACE De nombreuses populations
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TABLE OF CONTENTS Abstract………
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LIST OF TABLES Table 1: Contaminant
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INTRODUCTION Why is there a need fo
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Limitations of RATL The RATL databa
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Contaminant a Species Code b Lifest
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Table 1- Field Residues - 20 Contam
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Table 2 - Field Studies - 2 Contami
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Table 2 - Field Studies - 12 Contam
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Table 3: Acute toxicity values from
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Contaminant a Species Code b azinph
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Contaminant a Species Code b tar XE
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Table 4: Laboratory studies not inc
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Contaminant a Species Code b Cd AMG
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Page 213 and 214: Contaminant a Species Code b Lifest
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Page 261 and 262: Contaminant a Contaminant b Concent
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Page 277 and 278: Table 6: pH study data. (Studies th
Page 279 and 280: Table 6 - pH Studies - 3 Species Co
Page 281 and 282: Species Code b Lifestage Study Endp
Page 289 and 290: Table 6 - pH Studies - 13 Species C
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Species Code b Lifestage Study Endp
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Table 7: Reviews of primary literat
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Table 7 - Reviews - 3 Review Title
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Table 8 - Population Status - 2 Pop
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Table Notes Note a : see Appendix 2
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References - 2 Anderson, L.M. and R
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References - 4 Bantle, J.A., D.J. F
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References - 6 Beresford, W.A. , M.
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References - 8 Bishop, C.A, P. Ng,
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References - 10 Bragg, A.N. 1964. M
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References - 12 Burke, E.M. and F.H
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References - 14 Chattopadhyay, D.P.
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References - 16 Cooke, A.S. 1974. T
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References - 18 Dash, M.C. and A.K.
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References - 20 DeWitt, J.B., D.G.
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References - 22 Dutta, S.K. and P.
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References - 24 Elisyeyeva, K.H., H
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References - 26 Fontenot, L., C. Ro
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References - 28 Frisbie, M.P. and R
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References - 30 Godet, F., M. Babut
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References - 32 Gunther, R. and J.
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References - 34 Harfenist, A., T. P
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References - 36 Herkovits, J. and C
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References - 38 Hota, A. K. and M.C
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References - 40 Johnson, C.R. 1972a
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References - 42 Karns, D.R. 1984. T
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References - 44 Kraskowski, H.V., K
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References - 46 Leblanc, G.A. and L
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References - 48 Lotshaw, D.P. 1977.
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References - 50 Massot, M., J. Clob
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References - 52 Mendonca, M., J. Sh
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References - 54 Munro, D.F. 1949. E
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References - 56 Oliveira, E.M., D.V
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References - 58 Paulov, S. 1977b. T
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References - 60 Pierce, M.E. 1958.
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References - 62 Raj, T.P., A. Jeban
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References - 64 Rolfe, G. L., A. Ha
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References - 66 Sassaman, J.F. 1978
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References - 68 Semlitsch, R.D. and
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References - 70 Sparling, D.W., T.P
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References - 72 Surova, G.S. and A.
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References - 74 Tomar, V. and A. K.
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References - 76 Vijverberg, H.P.M.,
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References - 78 White, D.H. and A.J
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References - 80 Wyman, R.L. and J.
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Appendix 1a: Species codes in alpha
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Appendix 1a - Species Codes - 3 Cla
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Appendix 1a - Species Codes - 11 Cl
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Appendix 1a - Species Codes - 13 Cl
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Appendix 1b - Species Common Names
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Appendix 1c - Species Scientific Na
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Appendix 2a: Contaminant codes foun
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Appendix 2a - Contaminant Codes - 3
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Appendix 2b: Contaminants sorted by
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Appendix 2b - Contaminant Type - 3
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Appendix 4: Descriptions of exposur
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Appendix 6a: Glossary of Abbreviati
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Appendix 6b: Relevant biological an
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Appendix 6b - Glossary of RATL term
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RATL: A Database of Reptile and Amphibian Toxicology Literature

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