o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 4. ECOTOXICITY ID: 95-53-4 DATE: 07.01.2005 108 LC50 : = 124 Limit test : Analytical monitoring : no data Method : other: no data Year : 1983 GLP : no data Test substance : other TS: o-Toluidine, purity is not specified Reliability : (4) not assignable Original reference in Japanese, only short abstract in English 11.02.2004 (90) (91) Type : other: unknown Species : Oryzias latipes (Fish, fresh water) Exposure period : 48 hour(s) Unit : mg/l LC50 : 42 Limit test : Analytical monitoring : no data Method : other: no data Year : 1984 GLP : no data Test substance : other TS: o-Toluidine, purity is not specified Reliability : (4) not assignable Original reference in Japanese, not translated 11.02.2004 (90) 4.2 ACUTE TOXICITY TO AQUATIC INVERTEBRATES Type : semistatic Species : Daphnia magna (Crustacea) Exposure period : 48 hour(s) Unit : mg/l NOEC : 1.48 EC50 : 15.6 Limit Test : no Analytical monitoring : yes Method : OECD Guide-line 202 Year : 1996 GLP : yes Test substance : other TS: 99 % purity Result : CONCENTRATIONS Recovery rates always > 87 % EFFECTS (immobilization) 24h EC50 = 25.6 mg/L (95 % confidence limits: 19-34.5 mg/L) 48h EC50 = 15.6 mg/L (95 % confidence limits: 10.7-23.0 mg/L) 48h NOEC = 1.48 mg/L 48h EC100 =120 mg/L IMMOBILISATION measured cumulative number of immobilised concentration daphnid (percentage of immobility) (mg/L) 0hr 48hr ---------------------------------------------------------------- control 0 (0) 0 (0) 1.48 0 (0) 0 (0) UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 4. ECOTOXICITY ID: 95-53-4 DATE: 07.01.2005 4.44 0 (0) 4 (20) 13.3 4 (20) 9 (45) 40 14 (70) 14 (70) 120 20 (100) 20 (100) ---------------------------------------------------------------- MONITORING DATA water temperature: 19.8 - 20.5 °C dissolved oxygen: 8.6 - 8.9 mg/L (Saturated concentration at 20 °C is 8.84 mg/L) pH: 7.8 - 8.0 Test condition : TEST SYSTEM concentrations tested (nominal): 0 (control), 1.48, 4.44, 13.3, 40, 120 mg/L number of replicate: 4 number of daphnia per dose: 20 (5 daphnids x 4 replicates) water temperature: 20 +- 1 °C temperature, oxygen-content and pH were measured every 24 hours photo period: 16h-8h light-dark cycle by room light test parameter: immobility analytical monitoring: HPLC at 0 and 24 hours Reliability : (1) valid without restriction GLP guideline study Flag : Critical study for SIDS endpoint 15.11.2004 (99) Type : static Species : Daphnia magna (Crustacea) Exposure period : 48 hour(s) Unit : mg/l EC50 : = 5 Analytical monitoring : no data Method : OECD Guide-line 202 Year : 2001 GLP : no data Test substance : other TS: o-Toluidine, purity is not specified Remark : It is assumed that due to an edp (Electronic Data Processing) error the authors reported the values of vitamins B12 and biotin in the test medium to be 1.0 g and 0.75 g respectively, however, the correct data according to the standards are expected to be 1 µg vitamin B12 and 0.75 µg biotin in 1 litre. Result : 95 % confidence interval: 4.1-6.0 mg/l Test condition : The test was performed under the following conditions: - Daphnids were previously acclimated at 20 °C under a 16/8-h light/darkness cycle (less than 600 lux). - The test medium contained 293.8 mg CaCl2x2H2O, 123.3 mg MgSO4x7H2O, 5.8 mg KCl, 64.8 mg NaHCO3, 10 mg Na2SiO3x9H2O, 0.274 mg NaNO3, 0.143 mg KH2PO4, 0.184 mg K2HPO4, 2.86 mg H3BO3, 0.996 mg FeSO4x7H2O, 0.361 mg MnCl2x4H2O, 0.306 mg LiCl, 0.071 mg RbCl, 0.152 mg SrCl2x6H2O, 0.0168 mg CuCl2x2H2O, 0.013 mg ZnCl2, 0.010 CoCl2x6H2O, 3.25 µg KI, 2.19 g Na2SeO3, 0.575 g NH4CO3, 2.50 mg Na2EDTAx2H2O, 75 µg Thiamine HCl, 1.0 µg Vitamin B12 and 0.75 µg Biotin. - Young female juveniles, aged less than 24 h were used and 20 animals were exposed to the test solution. The surface of the test water was covered with teflon sheet to minimize evaporation of the culture medium and test substance. - Temperature, dissolved oxygen and pH in the test solutions for testing period were 20 °C, 8.0-9.1 mg/l and 7.5-8.5, respectively. - The total number of immobilized juveniles was determined after 24 and 48 h. UNEP PUBLICATIONS 109
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 11. Comments:
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OECD SIDS o-TOLUIDINE and transitio
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OECD SIDS o-TOLUIDINE methylene-bis
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OECD SIDS o-TOLUIDINE 6 REFERENCES
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OECD SIDS o-TOLUIDINE Bringmann G,
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OECD SIDS o-TOLUIDINE Hecht SS, El-
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OECD SIDS o-TOLUIDINE I U C L I D D
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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