o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

OECD SIDS o-TOLUIDINE
5. TOXICITY ID: 95-53-4
DATE: 07.01.2005
Vehicle : peanut oil
Doses :
Route of admin. : s.c.
Exposure time :
Method : other: dose finding for a cancerogenicity study see RE
Year : 1981
GLP : no
Test substance : as prescribed by 1.1 - 1.4
Result : LD50 = 1115 mg/kg body weight
95 % confidence limit: 984 - 1295 mg/kg bw
Test condition : TEST ORGANISMS:
- Animals: female Sprague Dawley rats
- Age: 6 weeks
ADMINISTRATION:
- Route: subcutan
- Vehicle: peanut oil
- Doses per time period: single dose
- Post dose observation period: 3 weeks
Reliability : (2) valid with restrictions
Insufficient documentation, investigated for dose finding only
12.06.2003 (151)
Type : LD50
Value : = 338 ml/kg bw
Species : mouse
Strain : B6C3F1
Sex : male
Number of animals : 5
Vehicle : other: DMSO
Doses :
Route of admin. : i.p.
Exposure time :
Method : other : LD50 calculated from the tables Thompson and Weil, 1952
Year : 1981
GLP : no data
Test substance : other TS: see freetext TC
Test condition : This study is part of a International Collaborative Program, published as:
Evaluation of Short-Term Tests for Cancerogens Progress in Mutation
Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981
CHEMICALS:
42 coded chemicals were investigated in short-term tests for
cancerogenicity in different laboratories
It should be suggested that only 100%-pure chemicals should be used
when evaluating a test system.
In the present work the compound with code no 41 is declared as otoluidine
hydrochloride, whereas in an the overall summary of this program
code no. 41 is declared as o-toluidine.
Reliability : (4) not assignable
Unsuitable test system
02.06.2004 (152) (153)
5.2.1 SKIN IRRITATION
Species : rabbit
Concentration : undiluted
UNEP PUBLICATIONS 147