o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
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OECD SIDS o-<strong>TOLUIDINE</strong><br />
5. TOXICITY ID: <strong>95</strong>-<strong>53</strong>-4<br />
DATE: 07.01.2005<br />
252<br />
Test substance : other TS: no data<br />
Result : No of animals with tumors: 7/36 treated animals and 19/140 controls, no<br />
further information<br />
Test condition : No of animals:: 1<strong>95</strong> controls; 75 dosed<br />
Reliability : (4) not assignable<br />
Secondary literature<br />
03.06.2004 (362)<br />
Species : mouse<br />
Sex : female<br />
Strain : Balb/c<br />
Route of admin. : s.c.<br />
Exposure period : last week of pregnancy<br />
Frequency of treatm. : 4-5 injections<br />
Post exposure period :<br />
Doses : 2 mg/animal<br />
Result : positive<br />
Control group : yes<br />
Method : other: tumor development in progeny<br />
Year : 1974<br />
GLP : no<br />
Test substance : other TS: o-tolidine see also RM<br />
Remark : This work is cited in RTECS and as second literature in MAK-Begründung<br />
1986, but test substance is not clearly defined. In the english translation<br />
test substance called o-tolidine.<br />
Result : After treatment with OT, half of the 16 mice studied were found to have<br />
tumors: adenomas of the lung in six and tumors of the mammary glands in<br />
five.<br />
Culturing of the kidneys of progeny from treated females resulted in<br />
specific hyperplastic pretoumerous alterations of the respective epithelium.<br />
Reliability : (4) not assignable<br />
Insufficient documentation and/or Secondary literature/ Test substance<br />
questionable<br />
03.06.2004 (363) (364)<br />
Species : mouse<br />
Sex : female<br />
Strain : Balb/c<br />
Route of admin. : s.c.<br />
Exposure period : during pregnancy<br />
Frequency of treatm. : every 4 - 5 days<br />
Post exposure period :<br />
Doses : 2 mg /animal<br />
Result :<br />
Control group :<br />
Method : other<br />
Year : 1969<br />
GLP : no<br />
Test substance : other TS: no data on purity<br />
Result : o-toluidine induced hyperplasie in lungs and kidney explantates 3-4 days<br />
after explantation<br />
Test condition : Females were injected every 4 - 5 days during pregnancy. One-two days<br />
before the delivery the pregnant animals were killed, embryonic tissues<br />
were explantated in organ cultures. Explants were examined by histological<br />
and autoradiography-methods.<br />
Reliability : (4) not assignable<br />
documentation insufficient for assessment<br />
03.06.2004 (365) (366)<br />
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