o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 4. ECOTOXICITY ID: 95-53-4 DATE: 07.01.2005 110 Reliability : (2) valid with restrictions Guideline study without detailed documentation Flag : Critical study for SIDS endpoint 18.06.2004 (100) Type : static Species : Daphnia magna (Crustacea) Exposure period : 48 hour(s) Unit : mg/l EC50 : .52 Analytical monitoring : no data Method : other: NEN 6501: Determination of acute toxicity with Daphnia magna (1980) with slight modifications (Van Leeuwen et al. 1985) Year : 1984 GLP : no data Test substance : other TS: o-Toluidine, purity > 99.5 % Method : Dutch Standardization Organization, Rijswijk, The Netherlands (1980), with slight modifications according to Van Leeuwen CJ et al. (1985). Aquatic toxicological aspects of dithiocarbamates and related compounds. Shortterm tests.Aquat. Toxicol. 7, 145-164. Remark : The daphnids were fed with 1.0E+08 cells/l Chorella pyrenoidosa. Result : 40 h-LC50 value and the 95 % confidence interval were calculated according to Litchfield JT and Wilcoxon F (1949). Exp. Therap. 96, 99-113. Test condition : 10 daphnids were used, one jar containing 50 ml medium Reliability : (2) valid with restrictions Test procedure in accordance with national standard methods, without detailed documentation Flag : Critical study for SIDS endpoint 11.11.2004 (30) Type : static Species : Daphnia magna (Crustacea) Exposure period : 72 hour(s) Unit : mg/l EC50 : .62 Limit Test : no Analytical monitoring : no data Method : other: Embryo development inhibition assay Year : 2001 GLP : no data Test substance : other TS: o-Toluidine, purity is not specified Result : 95 % confidence interval: 0.48-0.79 mg/l Test condition : - 20 embryos in 100 ml test solution were exposed to o-toluidine - Temperature: 20 °C - Dissolved oxygen: 7.8 - 9.1 mg/l - pH: 7.6 -8.9 - The development time was recorded for every hatched young animal and compared with the control. - Gross morphological abnormalities of hatched animals were inspected under a low-magnification microscope. Reliability : (2) valid with restrictions Study well documented, meets generally accepted scientific principles Flag : Critical study for SIDS endpoint 18.06.2004 (100) Type : static Species : Daphnia magna (Crustacea) Exposure period : 24 hour(s) UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 4. ECOTOXICITY ID: 95-53-4 DATE: 07.01.2005 Unit : mg/l EC50 (pH=6.0) : 8.9 EC50 (pH=7.8) : 6.6 EC50 (pH=9.0) : 3.5 Analytical monitoring : no data Method : other: not specified Year : 2000 GLP : no data Test substance : other TS: o-Toluidine, purity is not specified Method : The study assessed the toxicity of 13 anilines and 11 phenols to Daphnia magna at pH values of 6.0, 7.8 and 9.0. Result : The results were considered valid if dissolved oxygen measured at the end of the test was at least 60 % of saturation and if the percentage of immobilization observed for the controls was zero. Based on control experiments it is known that Daphnia can survive only between pH 6.0 and 9.0 in water, at pH values greater than 9.0 and less than 6.0, mortality was observed. Results are given as log (1/EC50), where EC50 is given in mol/l. pH=6.0 log(1/EC50) = 4.08 (EC50=8.9 mg/l) pH=7.8 log(1/EC50) = 4.21 (EC50=6.6 mg/l) pH=9.0 log(1/EC50) = 4.48 (EC50=3.5 mg/l) Test condition : - Daphnia magna were cultured parthenogenetically in an environmental chamber at a temperature of 22+/-2 °C, with a photoperiod of 14 h daylight / 10 h darkness. - 6-24 h old Daphnids were used for the toxicity tests. They were fed with a diet of green algae. - Acute toxicity tests were conducted with 10 animals in 25 ml of test water. - At each pH, 6 concentrations of the test substance were tried. 3 determinations were performed each time. - 3 different pH were tested: 6.0, 7.8 and 9 Reliability : (2) valid with restrictions Study meets generally accepted scientific principles 20.01.2004 (28) Type : static Species : Daphnia magna (Crustacea) Exposure period : 24 hour(s) Unit : mg/l EC0 : 2.5 EC50 : 26 EC100 : 60 Analytical monitoring : no Method : other: immobilization test according to Bringmann G and Kuehn R Year : 1977 GLP : no Test substance : other TS: o-Toluidine, purity is not specified Remark : - Effect endpoint: immobilization - Effect values refer to nominal TS concentrations Test condition : - Test organism: clone of wild population of Daphnia magna - Cultures of Daphnia magna were fed daily with green algae (Chorella vulgaris) - Triplicate parallel dilution series with 10 daphnids per vessel of 20 ml (age max. 24 h) - Temperature: 20-22 °C - Water source: tap water free of chlorine saturated with oxygen; hardness 16 ° (degree dH (German water hardness)) corresponding to 286 mg/l CaCO3, pH=7.6-7.7 Reliability : (2) valid with restrictions UNEP PUBLICATIONS 111
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 11. Comments:
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OECD SIDS o-TOLUIDINE and transitio
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OECD SIDS o-TOLUIDINE 6 REFERENCES
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OECD SIDS o-TOLUIDINE Bringmann G,
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OECD SIDS o-TOLUIDINE Hecht SS, El-
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OECD SIDS o-TOLUIDINE Stark M (1892
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OECD SIDS o-TOLUIDINE I U C L I D D
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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