o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
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OECD SIDS o-<strong>TOLUIDINE</strong><br />
5. TOXICITY ID: <strong>95</strong>-<strong>53</strong>-4<br />
DATE: 07.01.2005<br />
---no differences on spermatogenesis during the recovery period<br />
---increased number of corpus luteum in ovaries<br />
---no differences on fertility and number of implants observed<br />
for effects on progeny (F1): see chapter 5.8.2<br />
Test condition : o-toluidine was administered to 2/3 of the tail skin in male and female<br />
albino rats.<br />
number of animals: 15 per group<br />
doses: 8, 80 mg/kg bw<br />
treatment period: 4 month<br />
frequency: daily with a 4 hour duration<br />
After treatment period one part of animals were killed and genitals were<br />
examined. The other part were mated with untreated rats.<br />
Examinations:<br />
body weights<br />
spermatogenesis<br />
organ weights<br />
blood<br />
no detailed information on parameters investigated available<br />
Reliability : (4) not assignable<br />
documentation insufficient for assessment, no sufficient information on<br />
methods and results<br />
26.05.2004 (163)<br />
5.8.2 DEVELOPMENTAL TOXICITY/TERATOGENICITY<br />
Species : rat<br />
Sex : male/female<br />
Strain : no data<br />
Route of admin. : dermal<br />
Exposure period : 4 months<br />
Frequency of treatm. : daily<br />
Duration of test : 4 hours/day<br />
Doses : 8 and 80 mg/kg<br />
Control group : yes<br />
Method : other: effects on progeny (F1), see freetext ME)<br />
Year : 1983<br />
GLP : no data<br />
Test substance : other TS: o-toluidine, no data on purity<br />
Method : o-toluidine was administered to 2/3 of the tail skin in male and female<br />
albino rats.<br />
number of animals: 15 per group<br />
doses: 8, 80 mg/kg bw<br />
treatment period: 4 month<br />
frequency: daily with a 4 hour duration<br />
After treatment period one part of animals were killed and genitals were<br />
examined. The other part were mated with untreated rats.<br />
Examinations:<br />
body weights<br />
spermatogenesis<br />
organ weights<br />
blood<br />
no detailed information on parameters investigated available<br />
Result : Effects on progeny (F1)<br />
---progeny of high dose females:<br />
body weight gain was reduced in the f1 generation: this effect was<br />
reversible after 2 month<br />
---progeny of high dosed male or females:<br />
slight differences on relative organ weights in the f1 generation:<br />
<strong>UNEP</strong> PUBLICATIONS 263
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