o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

OECD SIDS o-TOLUIDINE
5. TOXICITY ID: 95-53-4
DATE: 07.01.2005
Strain : New Zealand white
Sex : male
Number of animals : 4
Vehicle : no data
Doses : individual doses not mentioned
Method : other: according to Draize et al., J.Pharmacol.Exper.Therap. 82, 377
(1944), see also freetext TC
Year : 1962
GLP : no
Test substance : other TS: o-toluidine, no data on purity
Result : LD50 = 3250 mg/kg
confidence limits as +- 1.96 standard deviation =
2010 - 5250 mg/kg
Test condition : TEST ORGANISMS:
Strain: New Zealand albino
Sex: male
Body weight: 2.5 - 3.5 kg
TEST DESIGN:
Penetration of rabbit skin is estimated by a technique closely skin to the
one day cuff method of Draize and associates.
The fur was removed from the entire trunk by clipping, and the dose was
retained beneath an impervious plastic film.
The animals were immobilized during the 24 hour contact period, after
which the film was removed and the rabbits were caged for the subsequent
14-day observation period.
Reliability : (2) valid with restrictions
No data on mortality, no data on clinical signs, no necropsy and no
histopathological examinations were performed/reported
Flag : Critical study for SIDS endpoint
02.06.2004 (145)
5.1.4 ACUTE TOXICITY, OTHER ROUTES
Type : LD50
Value : = 164 mg/kg bw
Species : rat
Strain : Sprague-Dawley
Sex : male
Number of animals :
Vehicle :
Doses :
Route of admin. : i.p.
Exposure time :
Method : other:according Hagen EC (1959) Acute Toxicity. The Editorial Committee
Association of Food and Drug Officials of the US
Year : 1978
GLP : no
Test substance : other TS: o-Toluidine hydrochloride, no data on purity
Reliability : (4) not assignable
Insufficient documentation
02.06.2004 (150)
Type : LD50
Value : = 246 mg/kg bw
Species : rat
Strain : Sprague-Dawley
Sex : female
UNEP PUBLICATIONS 145