o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

More documents

Recommendations

Info

OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 200 Reliability : (2) valid with restrictions no validated test methods 15.07.2004 (255) Type : Yeast gene mutation assay System of testing : Schizosaccharomyces pombe P1 Test concentration : 10, 29, 96, 288, 960, 1920 µg/ml Cycotoxic concentr. : > 960 µg/ml Metabolic activation : with and without Result : negative Method : other: Loprieno, N. (1981): Prog. Mutt. Res. 1, 424,433 Year : 1985 GLP : no data Test substance : other TS: o-toluidine, no data on purity Test condition : METABOLIC ACTIVATION: S9 mix liver homogenates from with phenobarbital and betanaphthoflavone induced rats Reliability : (2) valid with restrictions Method evaluation 15.07.2004 (256) (234) Type : Yeast gene mutation assay System of testing : Aspergillus nidulans, haploid strain 35 Test concentration : 0, 126, 252, 504 µg/ml DMSO Cycotoxic concentr. : > 2520 µg/ml Metabolic activation : no data Result : negative Method : other: growth-mediated technique Year : 1985 GLP : no data Test substance : other TS: o-toluidine, no data on purity Method : ---Incubation at 37°C in the dark for 5 days ---Controls: negative control: solvent (DMSO) positive control Diethylnitrosamine ---Statistic analysis: t-test non-parametric Mann-Whitmney U test Result : o-toluidin was unable to increase in a significant way the frequencies of methionine suppressors in strain 35. Reliability : (2) valid with restrictions Method evaluation 15.07.2004 (257) (258) (259) Type : DNA damage and repair assay System of testing : Escherichia coli W 3110 (pol A+), P 3478 (pol A-) Test concentration : 33.3 mg/ml Cycotoxic concentr. : no data Metabolic activation : with and without Result : negative Method : other: DNA Polymerase Deficient Assay, liquid suspension assay see freetext ME Year : 1981 GLP : no data Test substance : other TS: see freetext TC Method : The standard disc diffusion assay is reported in Slater et al. (1971) and Rosenkranz and Leifer (1979) UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 The modified liquid suspension assay is reported in McCoy et al. (1979) Test condition : This study is part of a International Collaborative Program, published as: Evaluation of Short-Term Tests for Cancerogens Progress in Mutation Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981 CHEMICALS: 42 coded chemicals were investigated in short-term tests for cancerogenicity in different laboratories It should be suggested that only 100%-pure chemicals should be used when evaluating a test system. ---In the present work the compound with code no 41 is declared as otoluidine hydrochloride, whereas in an the overall summary of this program code no. 41 is declared as o-toluidine. METABOLIC ACTIVATION: S9 mix - liver homogenates from with Aroclor 1254 induced male Wistar rats INTERPRETATION: Survival is expressed as the percent of control and the preferential inhibition of the pol A- strain as the survival index that is the ratio: percent survival of pol A-/ pol A+. Reliability : (2) valid with restrictions Method-Evaluation, unclear use: o-toluidine or o-toluidine hydrochloride 15.07.2004 (152) (260) Type : DNA damage and repair assay System of testing : E. coli K-12 343/113 uvrB-/recA-, E. coli K-12 343/113 uvrb+/recA+ Test concentration : 937 mM/l DMSO Cycotoxic concentr. : Metabolic activation : with and without Result : negative Method : other: DNA repair test in vitro Year : 1988 GLP : no data Test substance : other TS: o-toluidine, no data on purity (highest purity available) Method : End-point of genotoxicity is the preferential killing of the DNA repair deficient as opposed to the proficient strain. Bacteria were incubated together with the substance, with or without metabolic activation, in liquid suspension, and then they were spread on agar petri plates and the number of colonies were counted. Reliability : (4) not assignable special study, method evaluation, only one concentration tested 15.07.2004 (261) Type : DNA damage and repair assay System of testing : Escherichia coli WP2, WP67, CM871 Test concentration : 1000 µg/ml Cycotoxic concentr. : no data Metabolic activation : with and without Result : negative Method : other: Differential killing assay Year : 1981 GLP : no data Test substance : other TS: see freetext TC Test condition : This study is part of a International Collaborative Program, published as: Evaluation of Short-Term Tests for Cancerogens Progress in Mutation UNEP PUBLICATIONS 201
Page 1 and 2:
OECD SIDS o-TOLUIDINE FOREWORD INTR
Page 3 and 4:
OECD SIDS o-TOLUIDINE 11. Comments:
Page 5 and 6:
OECD SIDS o-TOLUIDINE and transitio
Page 7 and 8:
OECD SIDS o-TOLUIDINE countries), e
Page 9 and 10:
OECD SIDS o-TOLUIDINE 1.3 Physico-C
Page 11 and 12:
OECD SIDS o-TOLUIDINE methylene-bis
Page 13 and 14:
OECD SIDS o-TOLUIDINE Table 3 Photo
Page 15 and 16:
OECD SIDS o-TOLUIDINE With adapted
Page 17 and 18:
OECD SIDS o-TOLUIDINE Table 8 Geoac
Page 19 and 20:
OECD SIDS o-TOLUIDINE polluted site
Page 21 and 22:
OECD SIDS o-TOLUIDINE depending on
Page 23 and 24:
OECD SIDS o-TOLUIDINE prepared from
Page 25 and 26:
OECD SIDS o-TOLUIDINE 3.1.2 Acute T
Page 27 and 28:
OECD SIDS o-TOLUIDINE 3.1.4 Sensiti
Page 29 and 30:
OECD SIDS o-TOLUIDINE Inhalation Th
Page 31 and 32:
OECD SIDS o-TOLUIDINE males or fema
Page 33 and 34:
OECD SIDS o-TOLUIDINE examination y
Page 35 and 36:
OECD SIDS o-TOLUIDINE Conclusion Th
Page 37 and 38:
OECD SIDS o-TOLUIDINE According to
Page 39 and 40:
OECD SIDS o-TOLUIDINE The lowest te
Page 41 and 42:
OECD SIDS o-TOLUIDINE 4.2 Terrestri
Page 43 and 44:
OECD SIDS o-TOLUIDINE 6 REFERENCES
Page 45 and 46:
OECD SIDS o-TOLUIDINE Bringmann G,
Page 47 and 48:
OECD SIDS o-TOLUIDINE Hecht SS, El-
Page 49 and 50:
OECD SIDS o-TOLUIDINE phase extract
Page 51 and 52:
OECD SIDS o-TOLUIDINE Stark M (1892
Page 53 and 54:
OECD SIDS o-TOLUIDINE I U C L I D D
Page 55 and 56:
OECD SIDS o-TOLUIDINE 1. GENERAL IN
Page 57 and 58:
Page 59 and 60:
Page 61 and 62:
OECD SIDS o-TOLUIDINE 2. PHYSICO-CH
Page 63 and 64:
Page 65 and 66:
Page 67 and 68:
Page 69 and 70:
Page 71 and 72:
Page 73 and 74:
Page 75 and 76:
Page 77 and 78:
OECD SIDS o-TOLUIDINE 3. ENVIRONMEN
Page 79 and 80:
Page 81 and 82:
Page 83 and 84:
Page 85 and 86:
Page 87 and 88:
Page 89 and 90:
Page 91 and 92:
Page 93 and 94:
Page 95 and 96:
Page 97 and 98:
Page 99 and 100:
Page 101 and 102:
Page 103 and 104:
Page 105 and 106:
OECD SIDS o-TOLUIDINE 4. ECOTOXICIT
Page 107 and 108:
Page 109 and 110:
Page 111 and 112:
Page 113 and 114:
Page 115 and 116:
Page 117 and 118:
Page 119 and 120:
Page 121 and 122:
Page 123 and 124:
Page 125 and 126:
Page 127 and 128:
Page 129 and 130:
OECD SIDS o-TOLUIDINE 5. TOXICITY I
Page 131 and 132:
Page 133 and 134:
Page 135 and 136:
Page 137 and 138:
Page 139 and 140:
Page 141 and 142:
Page 143 and 144:
Page 145 and 146:
Page 147 and 148:
Page 149 and 150: OECD SIDS o-TOLUIDINE 5. TOXICITY I
Page 199: OECD SIDS o-TOLUIDINE 5. TOXICITY I
Page 251 and 252:
Page 253 and 254:
Page 255 and 256:
Page 257 and 258:
Page 259 and 260:
Page 261 and 262:
Page 263 and 264:
Page 265 and 266:
Page 267 and 268:
Page 269 and 270:
Page 271 and 272:
Page 273 and 274:
Page 275 and 276:
OECD SIDS o-TOLUIDINE 6. REFERENCES
Page 277 and 278:
Page 279 and 280:
Page 281 and 282:
Page 283 and 284:
Page 285 and 286:
Page 287 and 288:
Page 289 and 290:
Page 291 and 292:
Page 293 and 294:
Page 295 and 296:
Page 297:
show all

o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

Create successful ePaper yourself

Delete template?

Save as template?