o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
OECD SIDS o-<strong>TOLUIDINE</strong><br />
5. TOXICITY ID: <strong>95</strong>-<strong>53</strong>-4<br />
DATE: 07.01.2005<br />
The modified liquid suspension assay is reported in McCoy et al. (1979)<br />
Test condition : This study is part of a International Collaborative Program, published as:<br />
Evaluation of Short-Term Tests for Cancerogens Progress in Mutation<br />
Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981<br />
CHEMICALS:<br />
42 coded chemicals were investigated in short-term tests for<br />
cancerogenicity in different laboratories<br />
It should be suggested that only 100%-pure chemicals should be used<br />
when evaluating a test system.<br />
---In the present work the compound with code no 41 is declared as otoluidine<br />
hydrochloride, whereas in an the overall summary of this program<br />
code no. 41 is declared as o-toluidine.<br />
METABOLIC ACTIVATION:<br />
S9 mix - liver homogenates from with Aroclor 1254 induced male Wistar<br />
rats<br />
INTERPRETATION:<br />
Survival is expressed as the percent of control and the preferential<br />
inhibition of the pol A- strain as the survival index that is the ratio: percent<br />
survival of pol A-/ pol A+.<br />
Reliability : (2) valid with restrictions<br />
Method-Evaluation, unclear use: o-toluidine or o-toluidine hydrochloride<br />
15.07.2004 (152) (260)<br />
Type : DNA damage and repair assay<br />
System of testing : E. coli K-12 343/113 uvrB-/recA-, E. coli K-12 343/113 uvrb+/recA+<br />
Test concentration : 937 mM/l DMSO<br />
Cycotoxic concentr. :<br />
Metabolic activation : with and without<br />
Result : negative<br />
Method : other: DNA repair test in vitro<br />
Year : 1988<br />
GLP : no data<br />
Test substance : other TS: o-toluidine, no data on purity (highest purity available)<br />
Method : End-point of genotoxicity is the preferential killing of the DNA repair<br />
deficient as opposed to the proficient strain.<br />
Bacteria were incubated together with the substance, with or without<br />
metabolic activation, in liquid suspension, and then they were spread on<br />
agar petri plates and the number of colonies were counted.<br />
Reliability : (4) not assignable<br />
special study, method evaluation, only one concentration tested<br />
15.07.2004 (261)<br />
Type : DNA damage and repair assay<br />
System of testing : Escherichia coli WP2, WP67, CM871<br />
Test concentration : 1000 µg/ml<br />
Cycotoxic concentr. : no data<br />
Metabolic activation : with and without<br />
Result : negative<br />
Method : other: Differential killing assay<br />
Year : 1981<br />
GLP : no data<br />
Test substance : other TS: see freetext TC<br />
Test condition : This study is part of a International Collaborative Program, published as:<br />
Evaluation of Short-Term Tests for Cancerogens Progress in Mutation<br />
<strong>UNEP</strong> PUBLICATIONS 201
Change language