o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 186 Type : Ames test System of testing : Salmonella typhimurium TA102 Test concentration : 5 doses up to 2500 ug/plate in DMSO/Ethanol of Ethanol alone Cycotoxic concentr. : > 2500 ug/plate Metabolic activation : with and without Result : negative Method : other: modified to Maron and Ames (1983),Mutation Res. 113, 173, Levin DE (1982), Proc. Natl.Acad. Sci.(USA) 79, 7445 Year : 1992 GLP : no data Test substance : other TS: o-toluidine, highest purity available Remark : Thirty compounds were tested in a collaborative study (3 laboratories) for evaluating the new tester strain TA102 Reliability : (4) not assignable special study, method used poorly described, no detailed data on tested concentration, only one strain tested 15.07.2004 (218) Type : Ames test System of testing : Salmonella typhimurium (no further information) Test concentration : no data Cycotoxic concentr. : Metabolic activation : no data Result : negative Method : other: urine method Year : 1982 GLP : no data Test substance : other TS: o-toluidine, see freetext RM Remark : Substance administered to rats, urine tested, abstract only Reliability : (4) not assignable documentation insufficient for assessment, abstract only 15.07.2004 (219) Type : Bacterial forward mutation assay System of testing : Salmonella typhimurium TM 677 Test concentration : 50, 200, 500 µg/ml in DMSO Cycotoxic concentr. : no data Metabolic activation : with and without Result : negative Method : other: 8-Azaguanin-Resistenz-Test according Skopek et al., 1978 Year : 1985 GLP : no data Test substance : other TS: o-toluidine, no data on purity Test condition : METABOLIC ACTIVATION: S9 mix liver homogenates from Aroclor 1254 induced rats Reliability : (4) not assignable special study; method evaluation 15.07.2004 (220) Type : Bacterial forward mutation assay System of testing : Salmonella typhimurium TM 677 Test concentration : up to 500 µg/ml Cycotoxic concentr. : no data Metabolic activation : with Result : negative Method : other: 8-Azaguanin-Resistenz-Test according Skopek et al., 1978 Year : 1981 UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 GLP : no data Test substance : other TS: see freetext TC Test condition : This study is part of a International Collaborative Program, published as: Evaluation of Short-Term Tests for Cancerogens Progress in Mutation Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981 CHEMICALS: 42 coded chemicals were investigated in short-term tests for cancerogenicity in different laboratories It should be suggested that only 100%-pure chemicals should be used when evaluating a test system. ---In the present work the compound with code no 41 is declared as otoluidine hydrochloride, whereas in an the overall summary of this program code no. 41 is declared as o-toluidine. METABOLIC ACTIVATION: S9 mix - liver homogenates from with either PB or Aroclor 1254 induced rats Reliability : (4) not assignable Method-Evaluation, only one strain, insufficient documentation, unclear use: o-toluidine or o-toluidine hydrochloride 15.07.2004 (152) (221) Type : Bacterial forward mutation assay System of testing : Salmonella typhimurium BA 13, BA 9 Test concentration : 0-9 µmol Cycotoxic concentr. : no data Metabolic activation : with Result : positive Method : other: L-arabinose-resistence test with S typhimurium Year : 1988 GLP : no data Test substance : other TS: o-toluidine, no data on purity Method : The "Ara test" uses an araD mutant select changes from L-arabinose sensitivity (Ara-s) to L-arabinose resistance (Ara-r) in a medium containing L-arabinose plus glycerol. The Ara test is based on the fact that mutations in the structural gene for L-ribulose-5-phosphate 4-epimerase not only block the utilization of L-arabinose as a carbon source, but also lead to the accumulation of a toxic intermediate(presumably L-ribolose 5-phosphate). Bacterial growth is thus inhibited in the presence of L-arabinose and a carbon source unable to repress the araBAD operon. METABOLIC ACTIVATION: S9 mix liver homogenates from Aroclor 1254 induced rats Result : Significant mutagenic response with 30% S9 in the S9 mix Reliability : (4) not assignable special study; method evaluation, insufficient documentation 15.07.2004 (222) Type : Bacterial gene mutation assay System of testing : Salmonella typhimurium TA 98, TA 100; Escherichia Coli WP2, WP2uvrA(P) Test concentration : up to 500 µg/plate Cycotoxic concentr. : no data Metabolic activation : with and without Result : positive Method : other: Evaluation of mutagenesis assay using two species of bacteria Year : 1981 UNEP PUBLICATIONS 187
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 11. Comments:
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OECD SIDS o-TOLUIDINE 6 REFERENCES
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OECD SIDS o-TOLUIDINE Bringmann G,
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OECD SIDS o-TOLUIDINE Hecht SS, El-
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OECD SIDS o-TOLUIDINE I U C L I D D
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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