o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

More documents

Recommendations

Info

OECD SIDS o-TOLUIDINE 4. ECOTOXICITY ID: 95-53-4 DATE: 07.01.2005 122 nominal TS concentration Test condition : - Stock and preliminary cultures of protozoa are fed with viable bacteria (Escherichia coli). - Temperature = 25 °C; initial pH = 6.9 (adjusted) - The number of protozoa is determined by means of a cell counter (Coulter counter) after addition of a suitable electrolyte (10 % of a 1.1 % NaNO3 solution in double-distilled water filtered through a membrane filter (pore size = 0.2 µm) Reliability : (2) valid with restrictions Study meets generally accepted scientific principles Flag : Critical study for SIDS endpoint 30.01.2004 (121) (122) (113) (120) (114) Type : aquatic Species : Chilomonas paramaecium (Protozoa) Exposure period : 48 hour(s) Unit : mg/l EC5 : = 237 Analytical monitoring : no Method : other: cell multiplcation inhibition test according to Bringmann (1978) Year : 1980 GLP : no Test substance : other TS: o-Toluidine, purity is not specified Method : Bringmann G (1978). Bestimmung der biologischen Schadwirkung wassergefährdender Stoffe gegen Protozoen. I.Bakterienfressende Flagellaten (Modellorganismus: Entosiphon Sulcatum Stein). Z. Wasser u. Abwasser-Forsch.11, 210-215. Result : Reported TT (Toxicity Threshold) is comparable to EC5; value refers to nominal TS concentration Test condition : - Temperature = 20 °C; pH = 6.9 (adjusted) - The number of protozoa is determined by means of a cell counter (Coulter Counter) after addition of a suitable electrolyte (10 % of a 1.1 % NaNO3 solution in double-distilled water filtered through a membrane filter (pore size = 0.2 µm)) Reliability : (2) valid with restrictions Study meets generally accepted scientific principles Flag : Critical study for SIDS endpoint 29.01.2004 (123) (120) Type : aquatic Species : other protozoa: Spirostomum ambiguum Exposure period : 24 hour(s) Unit : mg/l LC50 : 5411 Analytical monitoring : no Method : other: Spirotox test Year : 1999 GLP : no Test substance : other TS: o-Toluidine, purity is not specified Result : Results were given in mmol/l after 24 and 48 h. For the deformation differences: 24 h and 48 h-EC50= 34.6+/-6.82 mmol/l = 3707.4+/-731 mg/l For lethality: 24 h and 48 h-EC50= 50.5+/-24.9 mmol/l = 5411+/-2668 mg/l Test condition : - Test organism: Spirostomum ambiguum, one of the biggest protozoans (2-3 mm long) - Diluent: Tyrod solution: 125 mg NaCl, 3.1 mg KCl, 3.1 mg CaCl2, 1.55 mg MgCl2, 15.6 mg NaHCO3 and 0.78 mg NaH2PO4 per liter of deionised water. Total hardness = 2.8 mg CaCO3/l and pH = 7.4 +/- 0.2. UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 4. ECOTOXICITY ID: 95-53-4 DATE: 07.01.2005 - Incubation took place in darkness at 25 °C. - 2 kinds of test responses were observed: a) different deformations and b) lethal response Reliability : (2) valid with restrictions Basic data given 23.12.2003 (124) Type : aquatic Species : Photobacterium phosphoreum (Bacteria) Exposure period : 15 minute(s) Unit : mg/l EC50 : 33 Analytical monitoring : no Method : other: see Test conditions Year : 1986 GLP : no Test substance : other TS: o-Toluidine, purity > 99.5 % Test condition : - Microtox test applied and results calculated according to manual of analyzer (Model 2055 Beckman 1982) - Incubation during 15 min. - Endpoint: 50 % inhibition of bioluminescence Reliability : (4) not assignable Documentation insufficient for assessment 16.12.2003 (30) Type : aquatic Species : Escherichia coli (Bacteria) Exposure period : Unit : mg/l EC0 : 1000 EC50 : 5000 Analytical monitoring : no Method : other: DIN-Standard 38412 Part 8 (Cell multiplication inhibition test) Year : 1976 GLP : no Test substance : other TS: o-Toluidine, purity is not specified Result : The same results were presented for Pseudomonas fluorescens. Test condition : Exposure period is not specified Reliability : (4) not assignable Documentation insufficient for assessment 16.12.2003 (125) 4.5.1 CHRONIC TOXICITY TO FISH Species : Oryzias latipes (Fish, fresh water) Endpoint : other: mortality, fish weigh and other behaviour symptoms Exposure period : 21 day(s) Unit : mg/l NOEC : 12.5 LC50 : > 100 Analytical monitoring : yes Method : other: OECD TG 204 "prolonged toxicity test" Year : 1996 GLP : yes Test substance : other TS: 99 % purity Result : CONCENTRATIONS UNEP PUBLICATIONS 123
Page 1 and 2:
OECD SIDS o-TOLUIDINE FOREWORD INTR
Page 3 and 4:
OECD SIDS o-TOLUIDINE 11. Comments:
Page 5 and 6:
OECD SIDS o-TOLUIDINE and transitio
Page 7 and 8:
OECD SIDS o-TOLUIDINE countries), e
Page 9 and 10:
OECD SIDS o-TOLUIDINE 1.3 Physico-C
Page 11 and 12:
OECD SIDS o-TOLUIDINE methylene-bis
Page 13 and 14:
OECD SIDS o-TOLUIDINE Table 3 Photo
Page 15 and 16:
OECD SIDS o-TOLUIDINE With adapted
Page 17 and 18:
OECD SIDS o-TOLUIDINE Table 8 Geoac
Page 19 and 20:
OECD SIDS o-TOLUIDINE polluted site
Page 21 and 22:
OECD SIDS o-TOLUIDINE depending on
Page 23 and 24:
OECD SIDS o-TOLUIDINE prepared from
Page 25 and 26:
OECD SIDS o-TOLUIDINE 3.1.2 Acute T
Page 27 and 28:
OECD SIDS o-TOLUIDINE 3.1.4 Sensiti
Page 29 and 30:
OECD SIDS o-TOLUIDINE Inhalation Th
Page 31 and 32:
OECD SIDS o-TOLUIDINE males or fema
Page 33 and 34:
OECD SIDS o-TOLUIDINE examination y
Page 35 and 36:
OECD SIDS o-TOLUIDINE Conclusion Th
Page 37 and 38:
OECD SIDS o-TOLUIDINE According to
Page 39 and 40:
OECD SIDS o-TOLUIDINE The lowest te
Page 41 and 42:
OECD SIDS o-TOLUIDINE 4.2 Terrestri
Page 43 and 44:
OECD SIDS o-TOLUIDINE 6 REFERENCES
Page 45 and 46:
OECD SIDS o-TOLUIDINE Bringmann G,
Page 47 and 48:
OECD SIDS o-TOLUIDINE Hecht SS, El-
Page 49 and 50:
OECD SIDS o-TOLUIDINE phase extract
Page 51 and 52:
OECD SIDS o-TOLUIDINE Stark M (1892
Page 53 and 54:
OECD SIDS o-TOLUIDINE I U C L I D D
Page 55 and 56:
OECD SIDS o-TOLUIDINE 1. GENERAL IN
Page 57 and 58:
Page 59 and 60:
Page 61 and 62:
OECD SIDS o-TOLUIDINE 2. PHYSICO-CH
Page 63 and 64:
Page 65 and 66:
Page 67 and 68:
Page 69 and 70:
Page 71 and 72: OECD SIDS o-TOLUIDINE 2. PHYSICO-CH
Page 77 and 78: OECD SIDS o-TOLUIDINE 3. ENVIRONMEN
Page 105 and 106: OECD SIDS o-TOLUIDINE 4. ECOTOXICIT
Page 121: OECD SIDS o-TOLUIDINE 4. ECOTOXICIT
Page 129 and 130: OECD SIDS o-TOLUIDINE 5. TOXICITY I
Page 173 and 174:
OECD SIDS o-TOLUIDINE 5. TOXICITY I
Page 175 and 176:
Page 177 and 178:
Page 179 and 180:
Page 181 and 182:
Page 183 and 184:
Page 185 and 186:
Page 187 and 188:
Page 189 and 190:
Page 191 and 192:
Page 193 and 194:
Page 195 and 196:
Page 197 and 198:
Page 199 and 200:
Page 201 and 202:
Page 203 and 204:
Page 205 and 206:
Page 207 and 208:
Page 209 and 210:
Page 211 and 212:
Page 213 and 214:
Page 215 and 216:
Page 217 and 218:
Page 219 and 220:
Page 221 and 222:
Page 223 and 224:
Page 225 and 226:
Page 227 and 228:
Page 229 and 230:
Page 231 and 232:
Page 233 and 234:
Page 235 and 236:
Page 237 and 238:
Page 239 and 240:
Page 241 and 242:
Page 243 and 244:
Page 245 and 246:
Page 247 and 248:
Page 249 and 250:
Page 251 and 252:
Page 253 and 254:
Page 255 and 256:
Page 257 and 258:
Page 259 and 260:
Page 261 and 262:
Page 263 and 264:
Page 265 and 266:
Page 267 and 268:
Page 269 and 270:
Page 271 and 272:
Page 273 and 274:
Page 275 and 276:
OECD SIDS o-TOLUIDINE 6. REFERENCES
Page 277 and 278:
Page 279 and 280:
Page 281 and 282:
Page 283 and 284:
Page 285 and 286:
Page 287 and 288:
Page 289 and 290:
Page 291 and 292:
Page 293 and 294:
Page 295 and 296:
Page 297:
show all

o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?