o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
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OECD SIDS o-<strong>TOLUIDINE</strong><br />
5. TOXICITY ID: <strong>95</strong>-<strong>53</strong>-4<br />
DATE: 07.01.2005<br />
histidine auxotrophs of S typhimurium (G46, TA1<strong>53</strong>5, TA10, C3076,<br />
TA1<strong>53</strong>7, D3057, TA1<strong>53</strong>8,TA98) and two tryptpphan auxotrophs of E coli<br />
(WP2 and WP2uvrA)<br />
METABOLIC ACTIVATION:<br />
S9 mix liver homogenates from Aroclor 1254 induced rats<br />
POSITIVE CONTROLS:<br />
Streptozotocin and 2-acetylaminofluorene<br />
DILUTIONS in DMSO<br />
Reliability : (4) not assignable<br />
data on concentration not given, documentation insufficient<br />
15.07.2004 (213) (214)<br />
Type : Ames test<br />
System of testing : S.typhimurium TA97, TA98, TA100, E.coli WP2uvrA<br />
Test concentration : 0, 39, 78, 156, 313, 625, 1250, 2500, 5000 µg/ml in DMSO<br />
Cycotoxic concentr. : no data<br />
Metabolic activation : with and without<br />
Result : negative<br />
Method : other: modified to Maron and Ames (1983)<br />
Year : 1994<br />
GLP : no data<br />
Test substance : other TS: o-toluidine, no data on purity<br />
Test condition : Controls: vehicle<br />
positive controls: 2-aminoanthracene; 2-(2-Furyl)-3-(5-nitro-2furyl)acrylamide<br />
Controls were functional<br />
METABOLIC ACTIVATION:<br />
S9 mix liver homogenates from phenobarbital and 5,6-benzoflavone<br />
induced rats<br />
Reliability : (2) valid with restrictions<br />
four strains only<br />
15.07.2004 (215) (216)<br />
Type : Ames test<br />
System of testing : Salmonella typhimurium TA 97, TA 98, TA 100, TA 102<br />
Test concentration : 320, 1000, 3200, 10000 µg/plate in DMSO<br />
Cycotoxic concentr. : >= 10000 ug/plate<br />
Metabolic activation : with and without<br />
Result : negative<br />
Method : other: modified to Maron and Ames (1983), Mutat. Res. 48, 271; see also<br />
freetext TC<br />
Year : 1985<br />
GLP : no data<br />
Test substance : other TS: o-toluidine, no data on purity<br />
Remark : positive controls were functional<br />
Test condition : METHOD: plate incorporation assay<br />
SOLVENT: DMSO SERVED AS NEGATIVE CONTROL<br />
POSITIVE CONTROLS:<br />
9-aminoacridine<br />
2-acetylaminofluorene<br />
aflatoxin B1<br />
Reliability : (4) not assignable<br />
no information about S9-preparation, no data on GLP and no data on purity<br />
of TS, only 4 strains used<br />
15.07.2004 (217)<br />
<strong>UNEP</strong> PUBLICATIONS 185
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