o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 196 µg/ml (strong cytotoxicity: 5% survival) with S9 mix and 3024 µg/ml (survival 8%) without S9 mix. Reliability : (2) valid with restrictions No validated test system 15.07.2004 (244) (234) Type : Gene mutation in Saccharomyces cerevisiae System of testing : strain D7 Test concentration : 10, 20, 50, 100, 200, 500 µg/ml Cycotoxic concentr. : >= 300 µg/ml Metabolic activation : with and without Result : negative Method : other: different method Year : 1885 GLP : no data Test substance : other TS: o-toluidine, no data on purity Remark : point mutation, mitotic gene conversion, mitotic segregation was investigated Reliability : (4) not assignable no details of the differnet method and the results 15.07.2004 (234) (245) Type : Gene mutation in Saccharomyces cerevisiae System of testing : Saccharomyces cerevisiae D61.M Test concentration : Cycotoxic concentr. : Metabolic activation : no data Result : negative Method : other: keine Daten Year : GLP : no data Test substance : no data Reliability : (4) not assignable secondary literature, review (a literature survey 1984-1990) 15.07.2004 (246) Type : Gene mutation in Saccharomyces cerevisiae System of testing : S.cerevisiae T1, T2 Test concentration : 100, 1000 µg/ml Cycotoxic concentr. : no data Metabolic activation : with and without Result : negative Method : other: mitotic crossing over assay according Zimmerman, 1975 Year : 1981 GLP : no data Test substance : other TS: see freetext TC Test condition : This study is part of a International Collaborative Program, published as: Evaluation of Short-Term Tests for Cancerogens Progress in Mutation Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981 CHEMICALS: 42 coded chemicals were investigated in short-term tests for cancerogenicity in different laboratories It should be suggested that only 100%-pure chemicals should be used when evaluating a test system. ---In the present work the compound with code no 41 is declared as otoluidine hydrochloride, whereas in the overall summary of this program UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 code no. 41 is declared as o-toluidine. METABOLIC ACTIVATION: S9 mix - liver homogenates from with Aroclor 1254 induced rats Reliability : (4) not assignable Method-Evaluation, no data on cytotoxicity, unclear use: o-toluidine or otoluidine hydrochloride 15.07.2004 (152) (247) Type : Gene mutation in Saccharomyces cerevisiae System of testing : Saccharomyces cervisiae D4 Test concentration : 0.33, 1.0, 3.33, 10.0, 33.33, 100.0, 333.33 µg/plate Cycotoxic concentr. : no data Metabolic activation : with and without Result : negative Method : other: modification of the method described by Zimmermann (1975) Year : 1981 GLP : no data Test substance : other TS: see freetext TC Test condition : This study is part of a International Collaborative Program, published as: Evaluation of Short-Term Tests for Cancerogens Progress in Mutation Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981 CHEMICALS: 42 coded chemicals were investigated in short-term tests for cancerogenicity in different laboratories It should be suggested that only 100%-pure chemicals should be used when evaluating a test system. ---In the present work the compound with code no 41 is declared as otoluidine hydrochloride, whereas in the overall summary of this program code no. 41 is declared as o-toluidine. METABOLIC ACTIVATION: S9 mix - liver homogenates from with Aroclor 1254 induced male Sprague Dawley rats Reliability : (2) valid with restrictions Method-Evaluation, unclear use: o-toluidine or o-toluidine hydrochloride 15.07.2004 (152) (248) Type : Gene mutation in Saccharomyces cerevisiae System of testing : strain D6 Test concentration : up to 2000 µg/ml Cycotoxic concentr. : no data Metabolic activation : with and without Result : positive Method : other: modified according Parry and Zimmermann (1976) Year : 1981 GLP : no data Test substance : other TS: see freetext TC Result : mitotic aneuploidy, the lowest positive concentration was 600 µg/ml Test condition : This study is part of a International Collaborative Program, published as: Evaluation of Short-Term Tests for Cancerogens Progress in Mutation Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981 CHEMICALS: 42 coded chemicals were investigated in short-term tests for cancerogenicity in different laboratories It should be suggested that only 100%-pure chemicals should be used UNEP PUBLICATIONS 197
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 11. Comments:
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OECD SIDS o-TOLUIDINE and transitio
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OECD SIDS o-TOLUIDINE countries), e
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OECD SIDS o-TOLUIDINE 1.3 Physico-C
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OECD SIDS o-TOLUIDINE methylene-bis
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OECD SIDS o-TOLUIDINE Table 3 Photo
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OECD SIDS o-TOLUIDINE With adapted
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OECD SIDS o-TOLUIDINE 3.1.2 Acute T
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OECD SIDS o-TOLUIDINE 3.1.4 Sensiti
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OECD SIDS o-TOLUIDINE Inhalation Th
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OECD SIDS o-TOLUIDINE examination y
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OECD SIDS o-TOLUIDINE Conclusion Th
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OECD SIDS o-TOLUIDINE The lowest te
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OECD SIDS o-TOLUIDINE 4.2 Terrestri
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OECD SIDS o-TOLUIDINE 6 REFERENCES
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OECD SIDS o-TOLUIDINE Bringmann G,
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OECD SIDS o-TOLUIDINE Hecht SS, El-
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OECD SIDS o-TOLUIDINE phase extract
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OECD SIDS o-TOLUIDINE Stark M (1892
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OECD SIDS o-TOLUIDINE I U C L I D D
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OECD SIDS o-TOLUIDINE 1. GENERAL IN
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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