o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

OECD SIDS o-TOLUIDINE
5. TOXICITY ID: 95-53-4
DATE: 07.01.2005
Species : rat
Strain : no data
Sex : no data
Number of animals : 12
Vehicle : other: air
Doses :
Exposure time : 7 hour(s)
Method : other: according to Smyth HF (1962), Am Ind Hyg Ass J 23: 95-107, see
also freetext ME
Year : 1977
GLP : no
Test substance : other TS: o-toluidine, no data on purity
Method : 12 rats were exposed to essentially saturated vapor for 7 hours at 20°C:
200 l air/hour was passed through a layer (5 cm) of the TS.
observation period: 14 days (according to Smyth)
observation for mortality and clinical signs of toxicity
Result : Mortality:
no deaths occurred during exposure and the post exposure observtion time
Signs of intoxications:
strong irritation of the mucous membrane, eyelid closure, gasping,
staggering gait
gross pathology:
no organ findings (details not given)
Reliability : (4) not assignable
not according to current standard, exposure concentration not given,
individual animal data not given
02.06.2004 (142)
5.1.3 ACUTE DERMAL TOXICITY
Type : other: methemoglobinemia
Value :
Species : rat
Strain : Wistar
Sex : female
Number of animals :
Vehicle : no data
Doses : 0.75, 1, and 1.25 % solution of o-toluidine (taken from graphic, dosing
volume not mentioned)
Method : other: single dermal applicationf exposure time: 2-6 hours, immediately
afterwards methemoglobin determination according to Evelyn-Malloy
Year : 1984
GLP : no
Test substance : other TS: o-toluidine, no data on purity
Result : Single dermal application resulted in methemoglobin level up to
approximately 10 %, value returned to normal within 48 hours
Dermal application (0.75, 1, and 1.25 % solution of o-toluidine) resulted in
dose-related increase in methemoglobinemia up to 8 %;
methemoglobin level increased slightly also with duration of exposure.
Reliability : (2) valid with restrictions
no data on number of animals, no data on purity of the substance, no data
on GLP, standard deviation not given
Flag : Critical study for SIDS endpoint
13.12.2004 (148)
Type : LD50
Value : = 3250 mg/kg bw
Species : rabbit
144
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