o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

More documents

Recommendations

Info

OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 204 Result : positive Method : other: Anchorage-independent survival assay according Suk et al., 1984 Year : 1985 GLP : no data Test substance : other TS: o-toluidine, no data on purity Reliability : (4) not assignable Documentation insufficient for assessment, Method-Evaluation 15.07.2004 (269) Type : other: lambda-induction assay System of testing : lysogenic strains of E. coli carried lambda prophage Test concentration : no data Cycotoxic concentr. : no data Metabolic activation : with Result : negative Method : other: according Hollstein et al., 1979 Year : 1981 GLP : no data Test substance : other TS: see freetext TC Remark : Zorotest Test condition : This study is part of a International Collaborative Program, published as: Evaluation of Short-Term Tests for Cancerogens Progress in Mutation Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981 CHEMICALS: 42 coded chemicals were investigated in short-term tests for cancerogenicity in different laboratories It should be suggested that only 100%-pure chemicals should be used when evaluating a test system. ---In the present work the compound with code no 41 is declared as otoluidine hydrochloride, whereas in an the overall summary of this program code no. 41 is declared as o-toluidine. METABOLIC ACTIVATION: S9 mix - liver homogenates from with Aroclor 1254 induced rats Reliability : (2) valid with restrictions Method-Evaluation, unclear use: o-toluidine or o-toluidine hydrochloride 15.07.2004 (270) (152) Type : other: lambda-induction assay System of testing : lysogenic strains of E. coli carried lambda prophage Test concentration : 500, 2500 µg/ml Cycotoxic concentr. : > 2500 µg/ml Metabolic activation : with Result : positive Method : other: according Moreau et al., 1976 Year : 1981 GLP : no data Test substance : other TS: see freetext TC Test condition : This study is part of a International Collaborative Program, published as: Evaluation of Short-Term Tests for Cancerogens Progress in Mutation Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981 CHEMICALS: 42 coded chemicals were investigated in short-term tests for cancerogenicity in different laboratories UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 It should be suggested that only 100%-pure chemicals should be used when evaluating a test system. ---In the present work the compound with code no 41 is declared as otoluidine hydrochloride, whereas in an the overall summary of this program code no. 41 is declared as o-toluidine. METABOLIC ACTIVATION: S9 mix - liver homogenates from with Aroclor 1254 induced rats Reliability : (2) valid with restrictions Method-Evaluation, unclear use: o-toluidine or o-toluidine hydrochloride 15.07.2004 (152) (271) Type : HGPRT assay System of testing : CHO-Zellen Test concentration : 0, 0.1, 0.25, 0,50 µl/ml DMSO Cycotoxic concentr. : >= 0.25 µg/ml DMSO Metabolic activation : with and without Result : ambiguous Method : other: experiment performed in roller bottles, treatment time: 4 days, metabolic activation by cocultivation with irradated primary Syrian hamster embryo cells Year : 1985 GLP : no data Test substance : other TS: o-toluidine, no data on purity Result : For o-toluidine a conclusion could not yet be reached for mutation at the Na/K-ATPase locus. Reliability : (3) invalid assay system evaluation, unsuitable test method 15.07.2004 (173) (272) Type : HGPRT assay System of testing : Chinese hamster V79 Test concentration : no data Cycotoxic concentr. : no data Metabolic activation : with and without Result : negative Method : other: modified method as described by Lee and Webber, 1982 Year : 1985 GLP : no data Test substance : other TS: o-toluidine, no data on purity Reliability : (4) not assignable assay system evaluation, detailed data such as concentration range cytotoxicity and results in detail are not reported 15.07.2004 (173) (273) Type : Mammalian cell gene mutation assay System of testing : Chinese hamster V79 cells Test concentration : 0, 0.1, 1.0, 5.0 mM in DMSO Cycotoxic concentr. : > 5 mM Metabolic activation : with and without Result : ambiguous Method : other: Kuroki, T. et al. (1977): Cancer Res. 37, 1044-1050 Year : 1985 GLP : no data Test substance : other TS: o-toluidine, no data on purity Result : Although marginal increase in mutation frequency (0.5 - 0.9 per 10E6 survivors) was observed there were no dose-response relationship. UNEP PUBLICATIONS 205
Page 1 and 2:
OECD SIDS o-TOLUIDINE FOREWORD INTR
Page 3 and 4:
OECD SIDS o-TOLUIDINE 11. Comments:
Page 5 and 6:
OECD SIDS o-TOLUIDINE and transitio
Page 7 and 8:
OECD SIDS o-TOLUIDINE countries), e
Page 9 and 10:
OECD SIDS o-TOLUIDINE 1.3 Physico-C
Page 11 and 12:
OECD SIDS o-TOLUIDINE methylene-bis
Page 13 and 14:
OECD SIDS o-TOLUIDINE Table 3 Photo
Page 15 and 16:
OECD SIDS o-TOLUIDINE With adapted
Page 17 and 18:
OECD SIDS o-TOLUIDINE Table 8 Geoac
Page 19 and 20:
OECD SIDS o-TOLUIDINE polluted site
Page 21 and 22:
OECD SIDS o-TOLUIDINE depending on
Page 23 and 24:
OECD SIDS o-TOLUIDINE prepared from
Page 25 and 26:
OECD SIDS o-TOLUIDINE 3.1.2 Acute T
Page 27 and 28:
OECD SIDS o-TOLUIDINE 3.1.4 Sensiti
Page 29 and 30:
OECD SIDS o-TOLUIDINE Inhalation Th
Page 31 and 32:
OECD SIDS o-TOLUIDINE males or fema
Page 33 and 34:
OECD SIDS o-TOLUIDINE examination y
Page 35 and 36:
OECD SIDS o-TOLUIDINE Conclusion Th
Page 37 and 38:
OECD SIDS o-TOLUIDINE According to
Page 39 and 40:
OECD SIDS o-TOLUIDINE The lowest te
Page 41 and 42:
OECD SIDS o-TOLUIDINE 4.2 Terrestri
Page 43 and 44:
OECD SIDS o-TOLUIDINE 6 REFERENCES
Page 45 and 46:
OECD SIDS o-TOLUIDINE Bringmann G,
Page 47 and 48:
OECD SIDS o-TOLUIDINE Hecht SS, El-
Page 49 and 50:
OECD SIDS o-TOLUIDINE phase extract
Page 51 and 52:
OECD SIDS o-TOLUIDINE Stark M (1892
Page 53 and 54:
OECD SIDS o-TOLUIDINE I U C L I D D
Page 55 and 56:
OECD SIDS o-TOLUIDINE 1. GENERAL IN
Page 57 and 58:
Page 59 and 60:
Page 61 and 62:
OECD SIDS o-TOLUIDINE 2. PHYSICO-CH
Page 63 and 64:
Page 65 and 66:
Page 67 and 68:
Page 69 and 70:
Page 71 and 72:
Page 73 and 74:
Page 75 and 76:
Page 77 and 78:
OECD SIDS o-TOLUIDINE 3. ENVIRONMEN
Page 79 and 80:
Page 81 and 82:
Page 83 and 84:
Page 85 and 86:
Page 87 and 88:
Page 89 and 90:
Page 91 and 92:
Page 93 and 94:
Page 95 and 96:
Page 97 and 98:
Page 99 and 100:
Page 101 and 102:
Page 103 and 104:
Page 105 and 106:
OECD SIDS o-TOLUIDINE 4. ECOTOXICIT
Page 107 and 108:
Page 109 and 110:
Page 111 and 112:
Page 113 and 114:
Page 115 and 116:
Page 117 and 118:
Page 119 and 120:
Page 121 and 122:
Page 123 and 124:
Page 125 and 126:
Page 127 and 128:
Page 129 and 130:
OECD SIDS o-TOLUIDINE 5. TOXICITY I
Page 131 and 132:
Page 133 and 134:
Page 135 and 136:
Page 137 and 138:
Page 139 and 140:
Page 141 and 142:
Page 143 and 144:
Page 145 and 146:
Page 147 and 148:
Page 149 and 150:
Page 151 and 152:
Page 153 and 154: OECD SIDS o-TOLUIDINE 5. TOXICITY I
Page 203: OECD SIDS o-TOLUIDINE 5. TOXICITY I
Page 255 and 256:
Page 257 and 258:
Page 259 and 260:
Page 261 and 262:
Page 263 and 264:
Page 265 and 266:
Page 267 and 268:
Page 269 and 270:
Page 271 and 272:
Page 273 and 274:
Page 275 and 276:
OECD SIDS o-TOLUIDINE 6. REFERENCES
Page 277 and 278:
Page 279 and 280:
Page 281 and 282:
Page 283 and 284:
Page 285 and 286:
Page 287 and 288:
Page 289 and 290:
Page 291 and 292:
Page 293 and 294:
Page 295 and 296:
Page 297:
show all

o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?