o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 162 Exposure period : no data Frequency of treatm. : every second day Post exposure period : Doses : 0.5 % solution in chloroform Control group : no data specified Method : other: no data Year : 1940 GLP : no data Test substance : other TS: o-toluidine, no data on purity Result : In the advanced stages (time not specified) massive bladder haemorrhage was found together with vacuolization of the bladder epithelial cells. In many cases there was papilliferous proliferation of the epithelial cells into the lumen. Reliability : (4) not assignable Secondary literature 24.05.2004 (162) Type : Sub-chronic Species : rat Sex : male/female Strain : no data Route of admin. : dermal Exposure period : 4 months Frequency of treatm. : 4 h/day Post exposure period : Doses : 0, 8, 80 mg/kg bw Control group : yes Method : other: see freetext TC Year : 1983 GLP : no data Test substance : other TS: no data on purity Remark : see also chapter 5.8.1 Fertility Result : -increase cell numbers of the spermatogenetic tissues -no differences on spermatogenesis during the recovery period -increased number of corpus luteum in ovaries -no differences on fertility and number of implantates observed -body weight gain was reduced in the f1 generation; this effect was reversible after 2 month -no changes in blood parameters and genitals of the exponates -slight differences on organ weights in the f1 generation Test condition : o-toluidine was administered to 2/3 of the tail skin in male and female albino rats. number of animals: 15 per group dosis: 8, 80 mg/kg bw treatment period: 4 month frequency: daily with a 4 hour duration After treatment period one part of animals were killed and genitals were examined. The other part were mated with untreated rats. Examinations: body weights spermatogenesis organ weights blood no detailed information on parameters investigated available Reliability : (4) not assignable documentation insufficient for assessment, no sufficient information on methods and results 18.12.2003 (163) UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 Type : Species : rat Sex : no data Strain : no data Route of admin. : oral unspecified Exposure period : 2.5 month (no further details given) Frequency of treatm. : daily Post exposure period : Doses : 35 mg/kg b.w./day (no further details given) Control group : no data specified Method : other: no data Year : 1967 GLP : no data Test substance : other TS: o-toluidine, no data on purity Result : increased methemoglobin, erythropenie, retikulozytose. Reliability : (4) not assignable Insufficient documentation and/or Secondary literature 02.06.2004 (144) 5.5 GENETIC TOXICITY ‘IN VITRO‘ Type : Ames test System of testing : Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537 Test concentration : 1) all strains: +/- S9: 0, 100, 333, 1000, 3333, 5000 µg/plate in Ethanol (abs); 2) TA 98, +S9, + Norharman: 0, 0.10, 0.33, 1.0, 3.3, 10, 33, 100 µg/plate in Ethanol (abs) Cycotoxic concentr. : preliminary test: TA100: > 5000 µg/plate (with and without S9-mix) TA98 with S9-mix and norharman: >= 100 ug/plate Metabolic activation : with and without Result : Method : other: Ames, Mutat. Res. 31, 347 (1975); Maron, Mutat. Res.113, 173 (1983) see also freetext ME Year : 1995 GLP : yes Test substance : other TS: o-toluidine, purity 99.95% Method : Preliminary Toxicity test ----Salmonella typhimurium TA100, with and without metabolic activation, vehicle: ethanol, dose-range: 6.7 - 5000 ug/plate ----Salmonella typhimurium TA98, with S9-mix and norharman, vehicle: ethanol, dose-range: 6.7 - 5000 ug/plate Mutagenicity assay: Plate incorporation methodology All tester strains were tested with and without metabolic activation. TA98 additionally treated with S9 + Norharman. METABOLIC ACTIVATION: S9 mix liver homogenates from aroclor 1254 induced male Sprague- Dawley rats Controls: negative control: solvent; positive controls: with S9: 2-aminoanthracene; without S9: 2-nitrofluorene; sodium azide; 9-aminoacridine; UNEP PUBLICATIONS 163
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 6 REFERENCES
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OECD SIDS o-TOLUIDINE Bringmann G,
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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