o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

OECD SIDS o-TOLUIDINE
5. TOXICITY ID: 95-53-4
DATE: 07.01.2005
System of testing : Salmonella typhimurium TA 98
Test concentration : in the presence of lithocholic acid: 1 and 2.5 µg/plate
absence of lithocholic acid: 1 - 5 µg/plate
Cycotoxic concentr. : no data
Metabolic activation : with
Result : positive
Method : other
Year : 1983
GLP : no data
Test substance : other TS: o-toluidine, no data on purity
Result : Addition of lithocholic acid inhibits the mutagenic
activity of o-toluidine in the presence of Arcolor S9 mix.
PB-S9 catalyzed mutagenic activation
Test condition : METABOLIC ACTIVATION:
S9 mix prepared of liver homogenates either from Aroclor 1254 or
phenobarbital induced rats
Reliability : (4) not assignable
special study
15.07.2004 (226)
Type : other: Fluctuation test
System of testing : Salmonella typhimurium TA 98, TA 100
Test concentration : 0, 10, 100, 200, 500, µg/ml
Cycotoxic concentr. : 500 µg/ml
Metabolic activation : with and without
Result : ambiguous
Method : other: Hubbard et al., (1977)
Year : 1981
GLP : no data
Test substance : other TS: see freetext TC
Test condition : This study is part of a International Collaborative Program, published as:
Evaluation of Short-Term Tests for Cancerogens Progress in Mutation
Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981
CHEMICALS:
42 coded chemicals were investigated in short-term tests for
cancerogenicity in different laboratories
It should be suggested that only 100%-pure chemicals should be used
when evaluating a test system.
---In the present work the compound with code no 41 is declared as otoluidine
hydrochloride, whereas in an the overall summary of this program
code no. 41 is declared as o-toluidine.
METABOLIC ACTIVATION:
Test compound was evaluated under three conditiones with each strain: 1.
without exogenous metabolic activation
2. with S9-fraction - liver homogenates from uninduced Sprague Dawley
rats
3. with freshley isolated hepatocytes
Reliability : (2) valid with restrictions
Method-Evaluation, unclear use: o-toluidine or o-toluidine hydrochloride
15.07.2004 (152) (227)
Type : other: Microtiter fluctuation test
System of testing : Escherichia coli WP2uvrA, Salmonella typhimurium TA 98, TA 1535, TA
1538
Test concentration : 10, 100, 300 µg/ml
Cycotoxic concentr. : preliminary cytotoxicity test
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