o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 220 Method : other: alkalische elution; Bradley et al., 1982 Year : 1985 GLP : no data Test substance : other TS: o-toluidine, no data on purity Result : o-toluidine induced strand breaks at less than 30% toxicity Test condition : Metabolic Activation: intrinsic Positive controls: 0.3 mM Dimethylnitrosamine Negative controls: concurrent solvent Criterion for a positive result: 3-fold increase in elution rate compared to the concurrent negative control to be a biologically significant increase in DNA single-strand breaks and a positive result Reliability : (2) valid with restrictions no data on purity of TS and no GLP 15.07.2004 (302) (280) (303) Type : Sister chromatid exchange assay System of testing : Chinese hamster ovary (CHO) cells Test concentration : 0.1, 1.0, 10, 100, 300 µg/ml Cycotoxic concentr. : no data Metabolic activation : with and without Result : positive Method : other Year : 1981 GLP : no data Test substance : other TS: see freetext TC Test condition : This study is part of a International Collaborative Program, published as: Evaluation of Short-Term Tests for Cancerogens Progress in Mutation Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981 CHEMICALS: 42 coded chemicals were investigated in short-term tests for cancerogenicity in different laboratories It should be suggested that only 100%-pure chemicals should be used when evaluating a test system. ---In the present work the compound with code no 41 is declared as otoluidine hydrochloride, whereas in an the overall summary of this program code no. 41 is declared as o-toluidine. METABOLIC ACTIVATION: S9 mix - liver homogenates from with Aroclor 1254 induced male Wistar rats Reliability : (2) valid with restrictions Method-Evaluation, unclear use: o-toluidine or o-toluidine hydrochloride 15.07.2004 (152) (304) (305) Type : Sister chromatid exchange assay System of testing : Chinese hamster ovary (CHO) cells Test concentration : see freetext TC Cycotoxic concentr. : Metabolic activation : without Result : positive Method : other: Induction of SCE in CHO cells treated with plasma of rats pretreated with o-Toluidine Year : 1985 GLP : no data UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 Test substance : other TS: o-toluidine, see freetext TC Test condition : CHO cells were incubated with plasma derived from treated rats containing active metabolites of the test chemical. Male rats were pretreated with 400 mg/kg bw o-Toluidine (injected intraperitoneal) and after 45 min blood was collected from the main aorta. Controls: negative control: plasma of rats treated with DMSO positive control: not mentioned Reliability : (4) not assignable no validated test procedure 15.07.2004 (306) Type : Sister chromatid exchange assay System of testing : human lymphocytes co-cultured with intact rat hepatocytes Test concentration : 0, 10, 50, 100, 200, 1000 µM Cycotoxic concentr. : no data Metabolic activation : with and without Result : positive Method : other: Krishna, G.J.N. and Oug, T. (1986): Teratogen. Carcinogen. Mutagen. 6, 321-330 Year : 1987 GLP : no data Test substance : other TS: o-toluidine, no data on purity Reliability : (4) not assignable no validated testsystem 15.07.2004 (307) Type : Sister chromatid exchange assay System of testing : V 79 Test concentration : +/- S9-mix: 0, 0.0025, 0.005, 0.01, 0.025 moles/l, solvent: DMSO Cycotoxic concentr. : Preliminary cytotoxicity tests without S9-mix, different concentrations and exposure time of 24 hours: 10 (exp.-2) moles/l leads to significantly reduced growth Metabolic activation : with and without Result : positive Method : other: see freetext TC Year : 1985 GLP : no data Test substance : other TS: o-toluidine, no data on purity Result : o-Toluidine was positive with and without S9-mix. The positive controls were functional. Test condition : Metabolic activation: S9 mix liver homogenates from Aroclor 1254 induced male Wistar rats Controls: negative control: DMSO positive controls: Diethylnitrosamine Exposure time: 2 hours All substances were tested in duplicate Evaluation: The total number of SCE's and the total number of chromosomes from the 30 cells/dose analysed were calculated. Statistical method: Student's t-test Reliability : (2) valid with restrictions no data on GLP and no data on the purity of TS 15.07.2004 (308) Type : Sister chromatid exchange assay System of testing : Chinese hamster ovary (CHO) cells UNEP PUBLICATIONS 221
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 11. Comments:
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OECD SIDS o-TOLUIDINE and transitio
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OECD SIDS o-TOLUIDINE countries), e
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OECD SIDS o-TOLUIDINE 1.3 Physico-C
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OECD SIDS o-TOLUIDINE methylene-bis
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OECD SIDS o-TOLUIDINE Table 3 Photo
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OECD SIDS o-TOLUIDINE With adapted
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OECD SIDS o-TOLUIDINE prepared from
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OECD SIDS o-TOLUIDINE 3.1.2 Acute T
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OECD SIDS o-TOLUIDINE 3.1.4 Sensiti
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OECD SIDS o-TOLUIDINE Inhalation Th
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OECD SIDS o-TOLUIDINE males or fema
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OECD SIDS o-TOLUIDINE examination y
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OECD SIDS o-TOLUIDINE Conclusion Th
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OECD SIDS o-TOLUIDINE According to
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OECD SIDS o-TOLUIDINE The lowest te
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OECD SIDS o-TOLUIDINE 4.2 Terrestri
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OECD SIDS o-TOLUIDINE 6 REFERENCES
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OECD SIDS o-TOLUIDINE Bringmann G,
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OECD SIDS o-TOLUIDINE Hecht SS, El-
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OECD SIDS o-TOLUIDINE phase extract
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OECD SIDS o-TOLUIDINE Stark M (1892
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OECD SIDS o-TOLUIDINE I U C L I D D
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OECD SIDS o-TOLUIDINE 1. GENERAL IN
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OECD SIDS o-TOLUIDINE 5. TOXICITY I
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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