o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE DuPont (1994). Urinary bladder toxicity - 14-day feeding study with o-tuluidine in rats. Report DuPont HLR 699-93, OTS0557449. DVGW (2004). Technologiezentrum Wasser, Personal communication. Eppinger P, Bornick H and Worch E (1999). Description and identification of aromatic amines in water from the river Elbe and an assessment of their importance for drinking water quality. Vom Wasser 92, 225-241. Eppinger P (2000). Aromatische Amine in der Elbe und ihr Verhalten bei der Trinkwasseraufbereitung. PhD Thesis, Dresden University of Technology, Dresden, Germany, 213pp (in German). Essington ME (1994). Adsorption of aniline and toluidines on montmorillonite. Soil Science 158 (3), 181-188. EU (1976). Directive 2002/61/EC of the European Parliament and of the Council of 27 July 1976 on the approximation of the laws, regulations and administrative provisions of the Member States relating to restrictions on the marketing and use of certain dangerous substances and preparations (76/769/EEC). http://www.dehp-facts.com/upload/documents/document37.pdf. EU (2002). Directive 2002/61/EC of the European Parliament and of the Council of 19 July 2002 amending for the nineteenth time Council Directive 76/769/EEC relating to restrictions on the marketing and use of certain dangerous substances and preparations (azocolourants). Off. J. L 243 , 11/09/2002 P. 0015 – 0018. EU (2003). Commission Directive 2003/3/EC of 6 January 2003 relating to restrictions on the marketing and use of "blue colourant" (twelfth adaptation to technical progress of Council Directive 76/769/EEC). Off. J. L 004 , 09/01/2003 P. 0012 – 0015. Fox M and Delow GF (1985). Tests for mutagenic activity at the HGPRT locus in Chinese hamster V79 cells in culture. Prog. Mut .Res. 5, 517-523. Freudenthal RI and Anderson DP (1995). A reexamination of recent publications suggesting otoluidine ma be a human bladder carcinogen. Reg. Toxicol. Pharmacol. 21, 199-202. Freudenthal RI, Stephens E and Anderson DP (1999). Determining the potential of aromatic amines to induce cancer of the urinary bladder. Int. J. Toxicol. 18, 353-359. Goldblatt MW (1955). Research in industrial health in the chemical industry. Brit. Industr. Med. 12, 1-20. Greim H (1997). Deutsche Forschungsgemeinschaft (DFG), Occupational Toxicants, critical data evaluation for MAK values and classification of Carcinogens: 2-nitrotoluene. VCH Weinheim, Vol. 8, 97-108. Gropp D (1958). Thesen zur Inauguraldissertation, Joh.-Gutenberg Universitaet Mainz; In: IARC Monographs on the Evaluation of the carcinogenic risk of chemicals to humans (1982)27, 168 Grummt T (2000). Untersuchungen zur Gentoxizitaet der Gewaesser. In: IAWR (de.), 16. Arbeitstagung der IAWR. Amsterdam, Selbstverlag. Gulati DK, Sabharwal PS and Shelby MD (1985). Tests for the induction of chromosomal aberrations and sister chromatid exchanges in cultured CHO cells. Prog. Mut. Res. 5, 413-426. Harris JC (1990). Rate of Hydrolysis. In: Lyman WJ, Reehl WF, Rosenblatt DH (eds.) Handbook of Chemical Property Estimation Methods. American Chemical Society, part 7. 46 UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE Hecht SS, El-Bayoumy K, Rivenson A and Fiala E (1982). Comparative carcinogenicity of otoluidine hydrochloride and o-nitrosotoluene in F344 rats. Cancer Lett 16, 103-108. Hermens J, Leeuwangh P and Musch A (1984). Quantitative structure-activity relationships and mixture toxicity studies of chloro- and alkalylanilines at an acute lethal toxicity level to the guppy (Poecilia reticulata). Ecotoxicol. Environ. Safety 8, 388-394. IARC (2000). o-Toluidine. Monographs Evaluat. Carcinogenic Risk Chem. Humans 77, 267-322. Ishidate M Jr and Sofuni T (1985). The in vitro chromosomal aberration test using Chinese hamster lung fibroblast cells in culture. Prog. Mut. Res. 5, 427-432. Ishidate M Jr, Harnois MC and Sofuni T (1988). A comparative analysis of data on clastogenicity of 951 chemical substances tested in mammalian cell cultures. Mutat Res 195, 151-213. Irvine WJ and Saxby MJ (1969). Steam volatile amines of Latakia tobacco leaf. Phytochem. 8, 473- 476. Juhnke I and Luedemann D (1978). Ergebnisse der Untersuchung von 200 chemischen Verbindungen auf akute Fischtoxizitaet mit dem Goldorfentest. Z. Wasser- Abwasser-Forsch. 11 (5), 161- 164. JETOC (1997). Mutagenicity Test Data of Existing Chemical Substances. Japan Chemical Industry Ecology-Toxicology & Information Center, Suppl. February 1997. Khlebnikova MI, Gladkova EV, Kurenko LT, Pshenitsyn AV and Shalin BM (1970). Problems of industrial hygiene and health status of workers engaged in the production of o-toluidine. Gig. Tr. Prof. Zabol 14, 7-10 (in Russian, cited according to IARC 2000). Kiese M (1963). The effect of certain substituents upon the N-oxidation of aniline in vivo. Naunyn Schmiedebergs Arch. exp. Pathol. Pharmakol. 244, 387-404. Kim Y and Lee D (2002). Solubility enhancement of PCDD/F in the presence of dissolved humic matter. Journal of Hazardous Materials B91, 113-127. Kleniewska D (1975). Studies on hypersensitivity to "para-group". Berufsdermatosen 23, 31-36. Knezovich JP and Crosby DG (1985). Fate and metabolism of o-toluidine in the marine bivalve molluscs Mytilus edulis and Crassostrea gigas. Environ. Tox. Chem. 4, 435-446. Koenemann H (1981). Quantitative structure-activity relationships in fish toxicity studies. Part 1: Relationship for 50 industrial pollutants. Toxicology 19, 209-221. Kolesnichenko TS and Shabad LM (1979). Organ cultures of embryonic target tissues exposed transplacentally to chemical substances as a test-system for rapid evaluation of carcinogenicity. Neoplasma 26, 369-379. Kromann A and Christensen TH (1998). Degradability of organic chemicals in a landfill environment studied by in situ and laboratory leachate reactors. Waste Manage Res 16: 437 - 445. Kuhn EP and Suflita JM (1989). Anaerobic biodegradation of nitrogen-substituted and sulfonated benzene aquifer contaminants. Haz. Waste Haz. Mat. 6(2), 121-133. Kuroda Y, Yokoiyama A and Kada T (1985). Assays for the induction of mutagens to 6-thioguanine restance in Chinese hamster V79 cells culture. Prog Mut Res 5, 537-542. UNEP PUBLICATIONS 47
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