o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 222 Test concentration : 0, 125, 250, 500, 1000 µg/ml Cycotoxic concentr. : Preliminary cytotoxicity test Metabolic activation : with and without Result : positive Method : other: see freetext TC Year : 1985 GLP : no data Test substance : other TS: o-toluidine, no data on purity Result : Cytotoxicity was observed at the highest doses tested (no details) o-Toluidine showed a statistically significant increase in SCEs in absence of S9. the positive controls were functional. Test condition : Metabolic activation: S9 mix was prepared from liver homogenates from Aroclor 1254 induced male Sprague-Dawley rats Solvent: DMSO Controls: negative control: solvent positive controls: MNNG, BP, 2-AAF Incubation time: 5 hours statistic evaluation by student's t-test Reliability : (2) valid with restrictions no data on purity and no information about GLP 15.07.2004 (309) Type : Sister chromatid exchange assay System of testing : Lymphocytes (human) Test concentration : 0, 1, 10, 100, 500, 600 µg/ml without S9-mix 0, 600 µg/ml with S9-mix Cycotoxic concentr. : no data Metabolic activation : with and without Result : negative Method : other: see freetext TC Year : 1985 GLP : no data Test substance : other TS: o-toluidine, no data on purity Result : positive control were functional without S9-mix: o-toluidine led to a slight elevation of the SCE rates, which did not even reach a doublint of the control values. Test condition : Method: 1-5 independent experiments with the blood from up to 5 different donors were performed: pooled data were reported Solvent: DMSO Controls: negative control: solvent positive control: Diepoxybutane (DEB) in the absence of ---S9-mix; Cyclophosphamid (CP) in the presence of S9-mix Incubation time: 48 hours, without S9-mix; 47 hours, with ---S9-mix METABOLIC ACTIVATION System: S9 mix was prepared fron liver homogenates from Aroclor 1254 induced male Sprague-Dawley rats Reliability : (4) not assignable only one dose used in the presence of metabolic activation, no data on GLP and no data on purity of TS, no information about cytotoxicity 15.07.2004 (310) Type : Sister chromatid exchange assay System of testing : RL 4 cells (epithelial-like cells from rat liver) Test concentration : (1) 0, 175, 350, 700 µg/ml (2) 21.8, 43.75, 87.5,µg/ml DMSO UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 Cycotoxic concentr. : between 500 - 750 µg/ml Metabolic activation : without Result : positive Method : other: sister-chromatid exchanges (see freetext TC) Year : 1983 GLP : no data Test substance : other TS: o-toluidine, no data on purity Result : o-toluidine induced increased frequencies of SCE as well as a small increase in chromatid damage. Trial (1) no data Trial (2) significant increasein fhe frequencies of SCE's/cell when compared with the control cultures Positive control was functional. Test condition : ---Test system RL4 cells (epithelial-like cell isolated from liver of 10-day-old male Wistar rat, cycle time: 13 h) ---Preliminary cytotoxicity test Cytotoxicity was measurement as plating efficiency Cytotoxicity reduced by 50% between 500 and 750 µg/ml and 700 µg/ml was used as the highest dose level. ---Incubation time: in the presence of BRdU: 24 hours ---Controls positive controls: 7,12-dimethylbenzanthracene 1µg/ml negative controls: solvent (DMSO) Reliability : (2) valid with restrictions Method evaluation 15.07.2004 (180) (281) (282) Type : other: Arabidopsis assay (plant) System of testing : Arabidopsis (Columbia wild type) Test concentration : Cycotoxic concentr. : Metabolic activation : without Result : positive Method : other: according Redei, 1980 Year : 1981 GLP : no data Test substance : other TS: o-toluidine, no data on purity Remark : Arabidopsis assay (Pflanze) Reliability : (4) not assignable special investigation 15.07.2004 (311) (312) Type : other: Degranulations test System of testing : postmitochondrial supernatant (PMS) from rat liver Test concentration : no data Cycotoxic concentr. : no data Metabolic activation : Result : negative Method : other Year : 1981 GLP : no data Test substance : other TS: o-toluidine, purity no data Reliability : (4) not assignable Method-Evaluation, unsuitable test 15.07.2004 (152) (313) Type : other: MVL assay (integration enhancement test) UNEP PUBLICATIONS 223
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 11. Comments:
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OECD SIDS o-TOLUIDINE and transitio
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OECD SIDS o-TOLUIDINE countries), e
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OECD SIDS o-TOLUIDINE 1.3 Physico-C
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OECD SIDS o-TOLUIDINE methylene-bis
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OECD SIDS o-TOLUIDINE Table 3 Photo
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OECD SIDS o-TOLUIDINE With adapted
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OECD SIDS o-TOLUIDINE prepared from
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OECD SIDS o-TOLUIDINE 3.1.2 Acute T
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OECD SIDS o-TOLUIDINE 3.1.4 Sensiti
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OECD SIDS o-TOLUIDINE Inhalation Th
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OECD SIDS o-TOLUIDINE examination y
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OECD SIDS o-TOLUIDINE Conclusion Th
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OECD SIDS o-TOLUIDINE According to
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OECD SIDS o-TOLUIDINE The lowest te
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OECD SIDS o-TOLUIDINE 4.2 Terrestri
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OECD SIDS o-TOLUIDINE 6 REFERENCES
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OECD SIDS o-TOLUIDINE Bringmann G,
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OECD SIDS o-TOLUIDINE Hecht SS, El-
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OECD SIDS o-TOLUIDINE phase extract
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OECD SIDS o-TOLUIDINE Stark M (1892
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OECD SIDS o-TOLUIDINE I U C L I D D
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OECD SIDS o-TOLUIDINE 1. GENERAL IN
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OECD SIDS o-TOLUIDINE 2. PHYSICO-CH
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OECD SIDS o-TOLUIDINE 5. TOXICITY I
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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