o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 234 Result : negative Method : other: BUdR tablet method according Allen et al., 1977, Cytogenet.Cell Genet. 18, 231 Year : 1983 GLP : no data Test substance : other TS:o-toluidine, no data on purity Test condition : TEST ORGANISMS: - weight: 26 - 32 g - No. of animals per dose: 3 per dose; 2 controls TEST PROCEDURE: 1 BUdR tablet was carefully placed subcutaneouslyinto each animal; 6 hours later TS was administered Conclusion : The activity although statistically significant, was slight and the dose response was not convincing. Consequently o-toluidine was not considered to be positive for SCE induction. Reliability : (4) not assignable no validated test method 18.05.2004 (335) Type : Somatic mutation assay Species : Drosophila melanogaster Sex : male/female Strain : other Route of admin. : other: oral feed of larvae Exposure period : until pupation Doses : 0, 1, 2, 5 mM in Tween 80 plus ethanol or water Result : positive Method : other: see freetext ME Year : 1994 GLP : no data Test substance : other TS: no data on purity Method : Drosophila wing spot test - one-generation somatic mutation and recombination assay (SMART) Result : o-toluidine induces a significant increase in the frequency of total spots only at the highest concentration (5mM). Reliability : (4) not assignable no validated test system 11.02.2004 (336) Type : Somatic mutation assay Species : Drosophila melanogaster Sex : female Strain : other: Leiden Standard, Hikone-R Route of admin. : oral feed Exposure period : growing cultures were exposed to chemicals during all three instar stages of larval development Doses : 0, 1, 2.5, 5.0 mM Result : positive Method : other: w/w+ assay according Vogel et al., 1991, Mutat. Res. 250, 291; statistical evaluation: chi-square for proportions Year : 1994 GLP : no data Test substance : other TS: o-toluidine hydrochloride Test substance : In the publication the test-substance is described as o-toluidine whereas the reported CAS no. 636-21-5 is corresponding to o-toluidine hydrochloride Reliability : (4) not assignable UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 no clear decision about the TS used 28.01.2004 (337) Type : other: DNA Single-strand break Species : mouse Sex : male Strain : other: Swiss CD-1 Route of admin. : i.p. Exposure period : once Doses : 0, 100 mg/kg bw Result : positive Method : other: alkaliche elution according to Cesarone et al., 1979, Anal. Biochem.100, 188-197 Year : 1980 GLP : no data Test substance : other TS: o-toluidine, no data on purity Method : Single i.p. injection of o-toluidine in to male Swiss mice. 4 hours after application isolation of nuclei from liver and kidneys and lysis on a membrane filter. DNA is eluted using alkaline buffer as function of molecular weight. As negative control: solvent Remark : Single-strand DNA-breaks were observed in liver and kidney nuclei. Reliability : (2) valid with restrictions no data on purity of TS, no data on GLP and only one dose used 18.05.2004 (338) (339) Type : other: DNA binding Species : rat Sex : male Strain : Sprague-Dawley Route of admin. : i.p. Exposure period : single administration Doses : 10, 20, 50, 100 mg/kg bw Result : Method : other: 32P post-labelling Year : 1993 GLP : no data Test substance : other TS: o-toluidine, no data on purity Reliability : (4) not assignable abstract, indufficient documentation 18.05.2004 (340) Type : other: DNA lesions (Comet assay) Species : mouse Sex : male Strain : other: ddY mice Route of admin. : gavage Exposure period : single dose Doses : 0, 600 mg/kg bw. in olive oil Result : positive Method : other: alkaline single cell gel electrophoresis (SCG) assay Year : 1999 GLP : no data Test substance : other TS: o-toluidine, purity > 99% Result : Stomach, liver, lung, urinary bladder, and brain were positive in the SCG assay. Test condition : TEST ORGANISMS: - Age: 7 weeks UNEP PUBLICATIONS 235
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 11. Comments:
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OECD SIDS o-TOLUIDINE 6 REFERENCES
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OECD SIDS o-TOLUIDINE Bringmann G,
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OECD SIDS o-TOLUIDINE Hecht SS, El-
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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