o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
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OECD SIDS o-<strong>TOLUIDINE</strong><br />
5. TOXICITY ID: <strong>95</strong>-<strong>53</strong>-4<br />
DATE: 07.01.2005<br />
220<br />
Method : other: alkalische elution; Bradley et al., 1982<br />
Year : 1985<br />
GLP : no data<br />
Test substance : other TS: o-toluidine, no data on purity<br />
Result : o-toluidine induced strand breaks at less than 30% toxicity<br />
Test condition : Metabolic Activation: intrinsic<br />
Positive controls: 0.3 mM Dimethylnitrosamine<br />
Negative controls: concurrent solvent<br />
Criterion for a positive result:<br />
3-fold increase in elution rate compared to the concurrent negative control<br />
to be a biologically significant increase in DNA single-strand breaks and a<br />
positive result<br />
Reliability : (2) valid with restrictions<br />
no data on purity of TS and no GLP<br />
15.07.2004 (302) (280) (303)<br />
Type : Sister chromatid exchange assay<br />
System of testing : Chinese hamster ovary (CHO) cells<br />
Test concentration : 0.1, 1.0, 10, 100, 300 µg/ml<br />
Cycotoxic concentr. : no data<br />
Metabolic activation : with and without<br />
Result : positive<br />
Method : other<br />
Year : 1981<br />
GLP : no data<br />
Test substance : other TS: see freetext TC<br />
Test condition : This study is part of a International Collaborative Program, published as:<br />
Evaluation of Short-Term Tests for Cancerogens Progress in Mutation<br />
Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981<br />
CHEMICALS:<br />
42 coded chemicals were investigated in short-term tests for<br />
cancerogenicity in different laboratories<br />
It should be suggested that only 100%-pure chemicals should be used<br />
when evaluating a test system.<br />
---In the present work the compound with code no 41 is declared as otoluidine<br />
hydrochloride, whereas in an the overall summary of this program<br />
code no. 41 is declared as o-toluidine.<br />
METABOLIC ACTIVATION:<br />
S9 mix - liver homogenates from with Aroclor 1254 induced male Wistar<br />
rats<br />
Reliability : (2) valid with restrictions<br />
Method-Evaluation, unclear use: o-toluidine or o-toluidine hydrochloride<br />
15.07.2004 (152) (304) (305)<br />
Type : Sister chromatid exchange assay<br />
System of testing : Chinese hamster ovary (CHO) cells<br />
Test concentration : see freetext TC<br />
Cycotoxic concentr. :<br />
Metabolic activation : without<br />
Result : positive<br />
Method : other: Induction of SCE in CHO cells treated with plasma of rats pretreated<br />
with o-Toluidine<br />
Year : 1985<br />
GLP : no data<br />
<strong>UNEP</strong> PUBLICATIONS
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