o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

OECD SIDS o-TOLUIDINE
5. TOXICITY ID: 95-53-4
DATE: 07.01.2005
Test condition : This study is part of a International Collaborative Program, published as:
Evaluation of Short-Term Tests for Cancerogens Progress in Mutation
Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981
CHEMICALS:
42 coded chemicals were investigated in short-term tests for
cancerogenicity in different laboratories
It should be suggested that only 100%-pure chemicals should be used
when evaluating a test system.
---In the present work the compound with code no 41 is declared as otoluidine
hydrochloride, whereas in an the overall summary of this program
code no. 41 is declared as o-toluidine.
METABOLIC ACTIVATION:
S9 mix - liver homogenates as described by Litton.
Reliability : (4) not assignable
Method-Evaluation, insufficient documentation, unclear use: o-toluidine or
o-toluidine hydrochloride
15.07.2004 (152) (230)
Type : Escherichia coli reverse mutation assay
System of testing : Escherichia coli WP2 uvrA + WP2 uvrA /pKM101
Test concentration : no data
Cycotoxic concentr. : no data
Metabolic activation : with and without
Result : negative
Method : other: see freetext ME
Year : 1981
GLP : no data
Test substance : other TS: see freetext TC
Method : Mutation tests were carried out using a preincubation method (30°C, 30
min) (Matsushima et al. 1980; Yahagi et al. 1977) with and without S9 mix
(PCB-induced rat liver metabolic activation system).
Test condition : This study is part of a International Collaborative Program, published as:
Evaluation of Short-Term Tests for Cancerogens Progress in Mutation
Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981
CHEMICALS:
42 coded chemicals were investigated in short-term tests for
cancerogenicity in different laboratories
It should be suggested that only 100%-pure chemicals should be used
when evaluating a test system.
---In the present work the compound with code no 41 is declared as otoluidine
hydrochloride, whereas in an the overall summary of this program
code no. 41 is declared as o-toluidine.
METABOLIC ACTIVATION:
S9 mix - liver homogenates from with PCB induced male Sprague Dawley
rats
Reliability : (4) not assignable
Method-Evaluation, no data on test concentrations, no data on cytotoxicity,
unclear use: o-toluidine or o-toluidine hydrochloride
15.07.2004 (152) (231)
Type : Bacillus subtilis recombination assay
System of testing : Bacillus subtilis H 17 rec+, M 45 rec-
Test concentration : 20µl/disk undiluted
UNEP PUBLICATIONS 191