o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 188 GLP : no data Test substance : other TS: see freetext TC Test condition : This study is part of a International Collaborative Program, published as: Evaluation of Short-Term Tests for Cancerogens Progress in Mutation Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981 CHEMICALS: 42 coded chemicals were investigated in short-term tests for cancerogenicity in different laboratories It should be suggested that only 100%-pure chemicals should be used when evaluating a test system. ---In the present work the compound with code no 41 is declared as otoluidine hydrochloride, whereas in an the overall summary of this program code no. 41 is declared as o-toluidine. METABOLIC ACTIVATION: three levels (4, 10 and 30% by volume) of S9 mix - liver homogenates from with Aroclor 1254 induced male Wistar rats Reliability : (4) not assignable Method-Evaluation, only two Salmonella strains tested, no data on negative controls, no data on cytotoxicity, no single data on results, unclear use: otoluidine or o-toluidine hydrochloride 15.07.2004 (152) (223) Type : Bacterial reverse mutation assay System of testing : Salmonella typhimurium Test concentration : up to 1000 µg/ml Cycotoxic concentr. : no data Metabolic activation : with Result : negative Method : other: Mutascreen automated system for bacterial mutagenicity tests Year : 1985 GLP : no data Test substance : other TS: o-toluidine, no data on purity Remark : Evaluation of an automated test system "Mutascreen" Reliability : (4) not assignable Documentation insufficient for assessment, Evaluation of an automated test system 15.07.2004 (224) Type : Bacterial reverse mutation assay System of testing : Salmonella typhimurium TA 98, TA 100; Escherichia coli WP2uvrA Test concentration : Cycotoxic concentr. : Metabolic activation : with Result : negative Method : other: Mutascreen automated system for bacterial mutagenicity tests Year : 1985 GLP : no data Test substance : other TS: o-toluidine hydrochloride Remark : Evaluation of an automated test system "Mutascreen" Reliability : (4) not assignable Documentation insufficient for assessment, Evaluation of an automated test system 15.07.2004 (225) Type : Salmonella typhimurium reverse mutation assay UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 System of testing : Salmonella typhimurium TA 98 Test concentration : in the presence of lithocholic acid: 1 and 2.5 µg/plate absence of lithocholic acid: 1 - 5 µg/plate Cycotoxic concentr. : no data Metabolic activation : with Result : positive Method : other Year : 1983 GLP : no data Test substance : other TS: o-toluidine, no data on purity Result : Addition of lithocholic acid inhibits the mutagenic activity of o-toluidine in the presence of Arcolor S9 mix. PB-S9 catalyzed mutagenic activation Test condition : METABOLIC ACTIVATION: S9 mix prepared of liver homogenates either from Aroclor 1254 or phenobarbital induced rats Reliability : (4) not assignable special study 15.07.2004 (226) Type : other: Fluctuation test System of testing : Salmonella typhimurium TA 98, TA 100 Test concentration : 0, 10, 100, 200, 500, µg/ml Cycotoxic concentr. : 500 µg/ml Metabolic activation : with and without Result : ambiguous Method : other: Hubbard et al., (1977) Year : 1981 GLP : no data Test substance : other TS: see freetext TC Test condition : This study is part of a International Collaborative Program, published as: Evaluation of Short-Term Tests for Cancerogens Progress in Mutation Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981 CHEMICALS: 42 coded chemicals were investigated in short-term tests for cancerogenicity in different laboratories It should be suggested that only 100%-pure chemicals should be used when evaluating a test system. ---In the present work the compound with code no 41 is declared as otoluidine hydrochloride, whereas in an the overall summary of this program code no. 41 is declared as o-toluidine. METABOLIC ACTIVATION: Test compound was evaluated under three conditiones with each strain: 1. without exogenous metabolic activation 2. with S9-fraction - liver homogenates from uninduced Sprague Dawley rats 3. with freshley isolated hepatocytes Reliability : (2) valid with restrictions Method-Evaluation, unclear use: o-toluidine or o-toluidine hydrochloride 15.07.2004 (152) (227) Type : other: Microtiter fluctuation test System of testing : Escherichia coli WP2uvrA, Salmonella typhimurium TA 98, TA 1535, TA 1538 Test concentration : 10, 100, 300 µg/ml Cycotoxic concentr. : preliminary cytotoxicity test UNEP PUBLICATIONS 189
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 11. Comments:
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OECD SIDS o-TOLUIDINE and transitio
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OECD SIDS o-TOLUIDINE countries), e
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OECD SIDS o-TOLUIDINE 1.3 Physico-C
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OECD SIDS o-TOLUIDINE Table 3 Photo
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OECD SIDS o-TOLUIDINE With adapted
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OECD SIDS o-TOLUIDINE 3.1.2 Acute T
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OECD SIDS o-TOLUIDINE 3.1.4 Sensiti
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OECD SIDS o-TOLUIDINE Inhalation Th
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OECD SIDS o-TOLUIDINE Conclusion Th
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OECD SIDS o-TOLUIDINE According to
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OECD SIDS o-TOLUIDINE The lowest te
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OECD SIDS o-TOLUIDINE 4.2 Terrestri
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OECD SIDS o-TOLUIDINE 6 REFERENCES
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OECD SIDS o-TOLUIDINE Bringmann G,
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OECD SIDS o-TOLUIDINE Hecht SS, El-
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OECD SIDS o-TOLUIDINE phase extract
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OECD SIDS o-TOLUIDINE Stark M (1892
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OECD SIDS o-TOLUIDINE I U C L I D D
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OECD SIDS o-TOLUIDINE 1. GENERAL IN
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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