o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 212 Thus o-toluidin was positive for both endpoints. Reliability : (4) not assignable IPCS Collaborative Study to evaluate an unusual test system 15.07.2004 (283) (284) (180) Type : Chromosomal aberration test System of testing : Chinese Hamster Lung (CHL) cells Test concentration : 0, 1.0, 1.25, 1.5 mg/ml DMSO Cycotoxic concentr. : in preliminary screening the conc at which cell growth was inhibited was determined: data not given Metabolic activation : with and without Result : positive Method : other: see freetext ME Year : 1988 GLP : no data Test substance : other TS: o-toluidine, no data on purity Method : Metabolic activation system (S9-mix) was prepared from Wistar or Fisher rats or BALB/c mice injected with 500 mg/kg bw PCB Incubation and recovery time: 6-18 hours No of metaphases: 200 Result : positive results only in the presence of the metabolic activation system no positive controls for the trials with and without S9-mix Reliability : (4) not assignable documentation insufficient for assessment 15.07.2004 (285) Type : Chromosomal aberration test System of testing : Chinese hamster ovary (CHO) cells Test concentration : 0, 100, 300, 900 µg/ml Cycotoxic concentr. : top dose selected as 50% inhibition of the mitotic index, compaired with controls Metabolic activation : with and without Result : negative Method : other: see freetext TC Year : 1985 GLP : no data Test substance : other TS: o-toluidine, no data on purity Result : An increased chromosomal aberration frequency was observed only at the intermediate dose (300 µg/ml) in the presence of metaboic activation and a treatment time of 3 hours. Summary results = negative Positive controls were functional. Test condition : Treatment time: with S9-mix. 3 hours without S9-mix: 12 hours Controls: negative controls: untreated cultures; solvent treated cultures positive controls: cyclophosphamide; aflatoxin B1 METABOLIC ACTIVATION: S9 mix was prepared from rat liver homogenates from Phenobarbital induced male Sprague-Dawley rats Analysis of results UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 Fisher's exact test for significance result is considered positive when a dose-related increase in frequencies of chromosomal aberrations Reliability : (2) valid with restrictions no data on purity of TS and no data on GLP 15.07.2004 (178) (180) (286) Type : Chromosomal aberration test System of testing : Chinese hamster ovary (CHO) cells Test concentration : 0, 5, 10, 20 mM in DMSO Cycotoxic concentr. : no data Metabolic activation : with and without Result : negative Method : other: see freetext test conditions Year : 1985 GLP : no data Test substance : other TS: o-toluidine, no data on purity Test condition : Exponentially-growing cells were treated for 1 h at 37°C with different concentrations of the test substance in presence or absence of S9 mix. Cells were fixed at 3 different times following treatment from 13 to 19 h. METABOLIC ACTIVATION: S9 mix (no further information) Controls: vehicle; positive: methyl methanesulfonate; cyclophosphamide Reliability : (4) not assignable no data on cytotoxicity 15.07.2004 (178) (180) (287) Type : DNA damage and repair assay System of testing : primary hepatocytes (human, rat) Test concentration : 1.8-5.6 mM Cycotoxic concentr. : no data Metabolic activation : no data Result : negative Method : other: alkaline-elution technique, exposure time: 20 hours Year : 1991 GLP : no data Test substance : other TS: o-toluidine, no data on purity Remark : Abstract of Congress Report Result : o-toluidine (1.8-5.6 mM) was ineffective in both species Reliability : (4) not assignable documentation insufficient for assessment 15.07.2004 (288) (289) Type : Unscheduled DNA synthesis System of testing : HeLa S3 cells Test concentration : no data Cycotoxic concentr. : no data Metabolic activation : with and without Result : positive Method : other Year : 1981 GLP : no data Test substance : other TS: see freetext TC Result : no concentration range or individual resuls were given: o-toluidine was tested negative in the absence of S9-mix. UNEP PUBLICATIONS 213
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 11. Comments:
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OECD SIDS o-TOLUIDINE 6 REFERENCES
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OECD SIDS o-TOLUIDINE Bringmann G,
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OECD SIDS o-TOLUIDINE Hecht SS, El-
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OECD SIDS o-TOLUIDINE I U C L I D D
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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