o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 152 24 hrs: 1/1/1/1/1/1 48 hrs: 1/1/1/3/1/1 72 hrs: 1/1/1/3/1/1 8 days: 1/1/1/1/1/1 In summary: Primary irritation score: 31.3 of max score 110. The treatment led to slight corneal opacity, slight to moderate conjunctival edema and redness. all findings were not reversible within the 8-day observation period. the control eyes which were not treated did not show any reactions except of one animal which showed slight conjunctival redness after 48 hours. Source : BASF AG Reliability : (2) valid with restrictions Scientifically valid study, but not according to current OECD guideline (eyes not rinsed) Flag : Critical study for SIDS endpoint 13.12.2004 (142) Species : rabbit Concentration : Dose : Exposure time : Comment : Number of animals : Vehicle : Result : highly irritating Classification : Method : other: according Carpenter CP and Smyth HF Jr (1946) Chemical Burns of the Rabbit Cornea. Am J Ophthal 29:1363, see also freetext TC Year : 1962 GLP : no Test substance : other TS: o-toluidine, no data on purity Result : Grade 8: highly irritating (max. possible Grade 10) Test condition : Application of TS: instillation of various volumes and concentrations as detailed by Carpenter and Smyth (1946), J. ind Hyg. Toxicol. 31, 343 Grading: Eye injury in rabbits is recorded in a 10-grade ordinal series and is based upon the degree of corneal necrosis that results from Grade 1 indicates at most a very small area of necrosis resulting from 0.5 ml of undiluted test substance in the eye. Grade 5 indicates a so-called severe burn from 0.005 ml, Grade 8 not explained Grade 10 indicates a severe burn from 0.5 ml of a 1% solution in water or propylene glycol. Reliability : (4) not assignable description insufficient for assessment 02.06.2004 (145) 5.3 SENSITIZATION Type : Patch-Test Species : human Concentration : 1 st : 2 % occlusive epicutaneous 2 nd : 3 rd : Number of animals : Vehicle : other: yellow paraffin Result : UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 Classification : Method : other: see freetext ME Year : GLP : no Test substance : other TS: chromatographically pure Method : For patch test filter paper was used 10 mm in diameter and was applied to the lateral aspect of the arm and covered with celophane extending 5 mm beyond the patch and fixed with adhesive tape. The results were read after 48 and 96 hours. Erythema and infiltration were recorded as positive result even if present only during the first reading. Remark : 40 patients, known to be hypersensitive to p-phenylene-diamine, were patch tested with 2% o-toluidine in yellow paraffin. 25 % of the patients showed positive reactions Reliability : (4) not assignable only patients included in the test Flag : Critical study for SIDS endpoint 02.06.2004 (155) 5.4 REPEATED DOSE TOXICITY Type : Sub-acute Species : rat Sex : male/female Strain : Fischer 344 Route of admin. : oral feed Exposure period : 14 days Frequency of treatm. : continuous Post exposure period : none Doses : 0, 500, 3000, 6000 ppm (approximately: 37.5, 225, 450 mg/kg bw/day) Control group : yes, concurrent no treatment LOAEL(methb) : = 500 ppm Method : other: Urinary bladder toxicity (see also freetext TC) Year : 1994 GLP : yes Test substance : other TS: o-toluidine, purity: 99.5 % Result : LOAEL: 500 ppm. TOXIC RESPONSE/EFFECTS - Mortality: no death occurred - Clinical signs: Wet and stained perineum were noted in female rats at 6000 ppm after one week. No other compound related clinical signs reported - Body weights: decreased (statistically significant in high dose animals of both sexes) (control, low, mid, high dose, day14): m: 233.1 g, 231.4 g, 231.6 g 218.3 g(p
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OECD SIDS o-TOLUIDINE 6 REFERENCES
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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