o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 232 Exposure period : single dose Doses : 15-30 % der LD50 Result : positive Method : other: thymidine incorporation inhibiting screening system Year : 1981 GLP : no data Test substance : other TS: no data on purity Reliability : (4) not assignable special test method 10.10.2003 (327) (328) (329) (330) Type : Micronucleus assay Species : mouse Sex : no data Strain : B6C3F1 Route of admin. : i.p. Exposure period : twice 0, 24h Doses : 80% of LD50 value Result : negative Method : other: according Heddle and Salamone, 1980 Year : 1981 GLP : no data Test substance : other TS: o-toluidine hydrochloride, see freetext TC Test condition : This study is part of a International Collaborative Program, published as: Evaluation of Short-Term Tests for Cancerogens Progress in Mutation Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981 CHEMICALS: 42 coded chemicals were investigated in short-term tests for cancerogenicity in different laboratories It should be suggested that only 100%-pure chemicals should be used when evaluating a test system. In the present work the compound with code no 41 is declared as otoluidine hydrochloride, whereas in an the overall summary of this program code no. 41 is declared as o-toluidine. In the first phase mice were injected intraperitoneally with 80% of the LD50 dose at 0 and 24h, and samples were taken at 48, 72, and 96 hours. While there was no increase in micronuclei the test substance were retestet with one injection of 100 and 50 % of the LD50 dose, and samples were taken at 30, 48 and 72 hours. Reliability : (4) not assignable Method-Evaluation, no specific data on given doses 18.05.2004 (152) (331) Type : Micronucleus assay Species : mouse Sex : male/female Strain : CD-1 Route of admin. : i.p. Exposure period : twice apart. 24h Doses : 0.04, 0.08, 0.16 mg/kg bw in DMSO Result : negative Method : other: according Schmid, 1973 Year : 1981 GLP : no data Test substance : other TS: see freetext TC UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 Test condition : This study is part of a International Collaborative Program, published as: Evaluation of Short-Term Tests for Cancerogens Progress in Mutation Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981 CHEMICALS: 42 coded chemicals were investigated in short-term tests for cancerogenicity in different laboratories It should be suggested that only 100%-pure chemicals should be used when evaluating a test system. In the present work the compound with code no 41 is declared as otoluidine hydrochloride, whereas in an the overall summary of this program code no. 41 is declared as o-toluidine. Doses: ½, ¼, 1/8 LD50 (0.388 mg/kg). Sampling 6 hours after last application Reliability : (2) valid with restrictions Method-Evaluation 02.06.2004 (152) (332) Type : Micronucleus assay Species : other: Pleurodelles waltl larvae Sex : no data Strain : Route of admin. : other: larvae reared in water containing test chemical Exposure period : 12 days Doses : 0.004µM; 0.0025 ppm Result : positive Method : other: newt larvae MN aasay Year : 1989 GLP : no data Test substance : other TS: o-toluidine, no data Reliability : (4) not assignable no validated test method 18.05.2004 (333) Type : Sister chromatid exchange assay Species : mouse Sex : no data Strain : Balb/c Route of admin. : i.p. Exposure period : Doses : 45 mg/kg Result : positive Method : other Year : 1983 GLP : no data Test substance : other TS: o-toluidine, no data Reliability : (4) not assignable documentation insufficient for assessment 18.05.2004 (334) Type : Sister chromatid exchange assay Species : Chinese hamster Sex : female Strain : no data Route of admin. : oral unspecified Exposure period : once Doses : 0, 100, 200, 300 mg/kg bw. UNEP PUBLICATIONS 233
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 6 REFERENCES
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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