o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
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OECD SIDS o-<strong>TOLUIDINE</strong><br />
5. TOXICITY ID: <strong>95</strong>-<strong>53</strong>-4<br />
DATE: 07.01.2005<br />
198<br />
when evaluating a test system.<br />
---In the present work the compound with code no 41 is declared as otoluidine<br />
hydrochloride, whereas in an the overall summary of this program<br />
code no. 41 is declared as o-toluidine.<br />
METABOLIC ACTIVATION:<br />
S9 mix - liver homogenates from with Aroclor 1254 induced rats<br />
Reliability : (2) valid with restrictions<br />
Method-Evaluation, unclear use: o-toluidine or o-toluidine hydrochloride<br />
15.07.2004 (152) (249) (250) (251)<br />
Type : Gene mutation in Saccharomyces cerevisiae<br />
System of testing : strain D3<br />
Test concentration : 0, 0.8 % in DMSO<br />
Cycotoxic concentr. : >0.8 %<br />
Metabolic activation : with and without<br />
Result : negative<br />
Method : other: see freetext ME<br />
Year : 1979<br />
GLP : no data<br />
Test substance : other TS: o-toluidine, no data on purity<br />
Method : Method:<br />
A suspension of S. cerevisiae D3 was incubated was incubated with otoluidine<br />
for 4 hours at 30°C on a roller drum<br />
S9-mix<br />
was prepared from rat livers pretreated with Aroclor 1254<br />
appropriate positive and negative controls were included (no further<br />
information)<br />
Reliability : (4) not assignable<br />
results from positive controls not reported, no detailed results from the<br />
assay with TS reported purity of TS not mentioned<br />
15.07.2004 (252) (2<strong>53</strong>)<br />
Type : Yeast Cytogenetic assay<br />
System of testing : strain 197/2d; strain rad3, rad18, rad52, trp2<br />
Test concentration : 100, 300, 500, 750 µg/ml<br />
Cycotoxic concentr. : no data<br />
Metabolic activation : with and without<br />
Result : positive<br />
Method : other: according Hollstein et al., 1979<br />
Year : 1981<br />
GLP : no data<br />
Test substance : other TS: see freetext TC<br />
Test condition : This study is part of a International Collaborative Program, published as:<br />
Evaluation of Short-Term Tests for Cancerogens Progress in Mutation<br />
Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981<br />
CHEMICALS:<br />
42 coded chemicals were investigated in short-term tests for<br />
cancerogenicity in different laboratories<br />
It should be suggested that only 100%-pure chemicals should be used<br />
when evaluating a test system.<br />
---In the present work the compound with code no 41 is declared as otoluidine<br />
hydrochloride, whereas in an the overall summary of this program<br />
code no. 41 is declared as o-toluidine.<br />
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