o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
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OECD SIDS o-<strong>TOLUIDINE</strong><br />
5. TOXICITY ID: <strong>95</strong>-<strong>53</strong>-4<br />
DATE: 07.01.2005<br />
212<br />
Thus o-toluidin was positive for both endpoints.<br />
Reliability : (4) not assignable<br />
IPCS Collaborative Study to evaluate an unusual test system<br />
15.07.2004 (283) (284) (180)<br />
Type : Chromosomal aberration test<br />
System of testing : Chinese Hamster Lung (CHL) cells<br />
Test concentration : 0, 1.0, 1.25, 1.5 mg/ml DMSO<br />
Cycotoxic concentr. : in preliminary screening the conc at which cell growth was inhibited was<br />
determined: data not given<br />
Metabolic activation : with and without<br />
Result : positive<br />
Method : other: see freetext ME<br />
Year : 1988<br />
GLP : no data<br />
Test substance : other TS: o-toluidine, no data on purity<br />
Method : Metabolic activation system (S9-mix)<br />
was prepared from Wistar or Fisher rats or BALB/c mice injected with 500<br />
mg/kg bw PCB<br />
Incubation and recovery time: 6-18 hours<br />
No of metaphases: 200<br />
Result : positive results only in the presence of the metabolic activation system<br />
no positive controls for the trials with and without S9-mix<br />
Reliability : (4) not assignable<br />
documentation insufficient for assessment<br />
15.07.2004 (285)<br />
Type : Chromosomal aberration test<br />
System of testing : Chinese hamster ovary (CHO) cells<br />
Test concentration : 0, 100, 300, 900 µg/ml<br />
Cycotoxic concentr. : top dose selected as 50% inhibition of the mitotic index, compaired with<br />
controls<br />
Metabolic activation : with and without<br />
Result : negative<br />
Method : other: see freetext TC<br />
Year : 1985<br />
GLP : no data<br />
Test substance : other TS: o-toluidine, no data on purity<br />
Result : An increased chromosomal aberration frequency was observed only at the<br />
intermediate dose (300 µg/ml) in the presence of metaboic activation and a<br />
treatment time of 3 hours.<br />
Summary results = negative<br />
Positive controls were functional.<br />
Test condition : Treatment time:<br />
with S9-mix. 3 hours<br />
without S9-mix: 12 hours<br />
Controls:<br />
negative controls:<br />
untreated cultures; solvent treated cultures<br />
positive controls:<br />
cyclophosphamide; aflatoxin B1<br />
METABOLIC ACTIVATION:<br />
S9 mix was prepared from rat liver homogenates from Phenobarbital<br />
induced male Sprague-Dawley rats<br />
Analysis of results<br />
<strong>UNEP</strong> PUBLICATIONS
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