o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 252 Test substance : other TS: no data Result : No of animals with tumors: 7/36 treated animals and 19/140 controls, no further information Test condition : No of animals:: 195 controls; 75 dosed Reliability : (4) not assignable Secondary literature 03.06.2004 (362) Species : mouse Sex : female Strain : Balb/c Route of admin. : s.c. Exposure period : last week of pregnancy Frequency of treatm. : 4-5 injections Post exposure period : Doses : 2 mg/animal Result : positive Control group : yes Method : other: tumor development in progeny Year : 1974 GLP : no Test substance : other TS: o-tolidine see also RM Remark : This work is cited in RTECS and as second literature in MAK-Begründung 1986, but test substance is not clearly defined. In the english translation test substance called o-tolidine. Result : After treatment with OT, half of the 16 mice studied were found to have tumors: adenomas of the lung in six and tumors of the mammary glands in five. Culturing of the kidneys of progeny from treated females resulted in specific hyperplastic pretoumerous alterations of the respective epithelium. Reliability : (4) not assignable Insufficient documentation and/or Secondary literature/ Test substance questionable 03.06.2004 (363) (364) Species : mouse Sex : female Strain : Balb/c Route of admin. : s.c. Exposure period : during pregnancy Frequency of treatm. : every 4 - 5 days Post exposure period : Doses : 2 mg /animal Result : Control group : Method : other Year : 1969 GLP : no Test substance : other TS: no data on purity Result : o-toluidine induced hyperplasie in lungs and kidney explantates 3-4 days after explantation Test condition : Females were injected every 4 - 5 days during pregnancy. One-two days before the delivery the pregnant animals were killed, embryonic tissues were explantated in organ cultures. Explants were examined by histological and autoradiography-methods. Reliability : (4) not assignable documentation insufficient for assessment 03.06.2004 (365) (366) UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 Species : rabbit Sex : no data Strain : no data Route of admin. : s.c. Exposure period : 6 weeks Frequency of treatm. : Post exposure period : Doses : 1 ml/kg bw Result : Control group : no data specified Method : other: no data Year : 1940 GLP : no data Test substance : other TS: no data on purity Result : Papillomatous changes in epithelial layer of bladder Test condition : 10 animals per group no further information Reliability : (4) not assignable Insufficient documentation and/or Secondary literature 03.06.2004 (162) (356) Species : guinea pig Sex : no data Strain : no data Route of admin. : s.c. Exposure period : 6 weeks Frequency of treatm. : Post exposure period : Doses : 0.5 ml in olive oil Result : Control group : no data specified Method : other: no data Year : 1940 GLP : no data Test substance : other TS: no data on purity Result : Animals died early in the experiment therefore no tumors reported Test condition : 10 animals per group no further information Reliability : (4) not assignable Insufficient documentation and/or Secondary literature 03.06.2004 (162) (356) Species : hamster Sex : male/female Strain : other: syrian golden hamsters Route of admin. : s.c. Exposure period : 53 weeks Frequency of treatm. : once / week Post exposure period : approx. 30 weeks Doses : 0, 1.9 mmol/kg bw in peanut oil Result : Control group : yes Method : other: carcinogenicity see freetext TC Year : 1983 GLP : no data Test substance : other TS: no data on purity Result : Mean survival time for treated groups were 61.3 weeks in males and 57.8 weeks in females. UNEP PUBLICATIONS 253
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 11. Comments:
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OECD SIDS o-TOLUIDINE 6 REFERENCES
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OECD SIDS o-TOLUIDINE Bringmann G,
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OECD SIDS o-TOLUIDINE Hecht SS, El-
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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