o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

OECD SIDS o-TOLUIDINE
5. TOXICITY ID: 95-53-4
DATE: 07.01.2005
individual observations not given
Flag : Critical study for SIDS endpoint
09.02.2004 (154)
Species : rabbit
Concentration : undiluted
Dose : .1 ml
Exposure time :
Comment : not rinsed
Number of animals : 6
Vehicle : other: none
Result : highly irritating
Classification :
Method : other: Draize Test according Fed. Reg. 38, No. 187, §1500.42, p. 27019,
1973 see also freetext ME
Year : 1978
GLP : no
Test substance : other TS: o-toluidine, purity: 99.5 %
Method : 100 µl of the testsubstance were applied into the conjunctival sac of one
eye of each of 6 White Vienna rabbits the non-treated adjacent eye served
as a control.
The animals were observed once on the treatment day and 24, 48, 72 hrs
as well as 8 days after application
Scoring: according to Draize Scores
Result : Rabbit: 1/2/3/4/5/6
*=evaluation not possible because the eyelids sticked together
1) Cornea
-----Opacity
1=slight, 2=moderate, 3=marked, 4=strong, na=narrowed pupils
24 hrs: 1 /1 /1 /1/1+na/1
48 hrs: 1 /1+na/1+na/*/1+na/1+na
72 hrs :1 /1 /1 /1 /1 /1 all rabbits with na
8 days: 1+na/1+na/1+na/1+na/1+na/1
-----Area of opacity
(range: 1=3/4)
24 hrs: 4/4/4/4/4/4
48 hrs: 4/4/4/*/4/4
72 hrs: 4/4/4/4/4/4
8 days: 2/3/4/4/3/3
2) Iris
1= slight injections, 2= iritis
24 hrs: 0/0/0/0/1/0
48 hrs: 0/0/1/*/1/1
72 hrs: 1/1/1/1/1/1
8 days: 1/1/1/1/1/0
3) Conjunctiva:
1=slight, 2=moderate, 3=strong, s=scar
-----redness
24 hrs: 2 /2 /2 /2 /2 /2+s
48 hrs: 2+s/2+s/2+s/* /2 /2+s
72 hrs: 2+s/2+s/2+s/2+s/2+s/2+s
8 days: 1+s/1+s/1+s/1+s/2+s/1+s
-----chemosis
24 hrs: 2/2/2/2/2/2
48 hrs: 1/2/2/2/2/2
72 hrs: 1/2/1/2/1/1
8 days: 1/1/0/1/1/0
-----discharge
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