o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

OECD SIDS o-TOLUIDINE
5. TOXICITY ID: 95-53-4
DATE: 07.01.2005
Classification :
Method : other: see freetext ME
Year :
GLP : no
Test substance : other TS: chromatographically pure
Method : For patch test filter paper was used 10 mm in diameter and was applied to
the lateral aspect of the arm and covered with celophane extending 5 mm
beyond the patch and fixed with adhesive tape.
The results were read after 48 and 96 hours.
Erythema and infiltration were recorded as positive result even if present
only during the first reading.
Remark : 40 patients, known to be hypersensitive to p-phenylene-diamine, were
patch tested with 2% o-toluidine in yellow paraffin.
25 % of the patients showed positive reactions
Reliability : (4) not assignable
only patients included in the test
Flag : Critical study for SIDS endpoint
02.06.2004 (155)
5.4 REPEATED DOSE TOXICITY
Type : Sub-acute
Species : rat
Sex : male/female
Strain : Fischer 344
Route of admin. : oral feed
Exposure period : 14 days
Frequency of treatm. : continuous
Post exposure period : none
Doses : 0, 500, 3000, 6000 ppm (approximately: 37.5, 225, 450 mg/kg bw/day)
Control group : yes, concurrent no treatment
LOAEL(methb) : = 500 ppm
Method : other: Urinary bladder toxicity (see also freetext TC)
Year : 1994
GLP : yes
Test substance : other TS: o-toluidine, purity: 99.5 %
Result : LOAEL: 500 ppm.
TOXIC RESPONSE/EFFECTS
- Mortality: no death occurred
- Clinical signs: Wet and stained perineum were noted in female rats at
6000 ppm after one week. No other compound related clinical signs
reported
- Body weights: decreased (statistically significant
in high dose animals of both sexes) (control,
low, mid, high dose, day14):
m: 233.1 g, 231.4 g, 231.6 g 218.3 g(p