o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 226 Test substance : other TS: o-toluidine hydrochloride, purity: 97.8 % Method : In order to obtain individuals for larval treatment Cantons S females and males were mated and eggs exposed in vials with standard cornmeal food containing the chemical plus solvent and solvent alone. Adult males emerging from treatment were mated at approximately 24 hours of age with two successive harems of 3 to 5 Basc females to establish 2 single day broods. Males were then discarded and the conventionals SLRL was carried out. statistical method: binominal distribution Result : treatment group versus concurrent control group: mortality: 50 % versus 0 %, sterility: 0 % versus 0 %; lethals: 0.12 % versus 0.12 % Reliability : (2) valid with restrictions no information on GLP Flag : Critical study for SIDS endpoint 18.05.2004 (323) Type : other: chromosomal aberrations Species : mouse Sex : male Strain : B6C3F1 Route of admin. : i.p. Exposure period : single administration Doses : 0, 150, 300, 600 mg/kg bw in DMSO Result : negative Method : other: according to Preston et al., 1987,Mutat. Res. 189,157-165, see also freetext TC Year : 1989 GLP : no data Test substance : other TS: o-toluidine hydrochloride, no data on purity Result : There was no increase in the aberration rates when compared to the negative controls. The positive control was functional. Test condition : In preliminary tests the MTD was determined; doses chosen were MTD, 0.5 MTD and 0.25 MTD TEST ORGANISMS: - Age: 10 - 16 weeks - No. of animals per dose: 8 ADMINISTRATION: - Vehicle: saline - Administration volume: 5 ml/kg body weight - Duration of test: animals were killed 17h after a single injections of o-toluidine hydrochloride, then samples of bone marrow were taken, 350-400 metaphases were scored - Control groups: negative (vehicle) control group and positive control (MMC) treated with single dose of 0.5 mg Mitomycin C/kg i.p. STATISTICAL EVALUATION: One tail trend test of Margolin; individual group means by a pairwise t-test utilizing the appropriate bonferoni correction Reliability : (2) valid with restrictions individual animal data not given, no information on GLP and substance purity Flag : Critical study for SIDS endpoint 18.05.2004 (324) UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 Type : Micronucleus assay Species : mouse Sex : male Strain : B6C3F1 Route of admin. : i.p. Exposure period : single administration Doses : 0, 75, 150, 300 mg/kg bw in DMSO Result : negative Method : other: according Preston et al., 1987 Year : 1989 GLP : no data Test substance : other TS: o-toluidine hydrochloride, no data on purity Result : ---clinical observations: Injections of 300 mg/kg bw had a very pronounced sedative effect; within 20-30 min after injection. they were totally immobile and showed minimal response to physical stimulus. ---PCE production was slightly suppressed. ---Positive control was functional. Test condition : In preliminary tests the MTD was determined; doses chosen were MTD, 0.5 MTD and 0.25 MTD TEST ORGANISMS: - Age: 10 - 16 weeks - No. of animals per dose: 8 ADMINISTRATION: - Vehicle: DMSO - Administration volume: 5 ml/kg body weight - Duration of test: animals were killed 24, 48, or 72 h after treatment and bone marrow samples were taken; 1000 polychromatic erythrocytes were taken from each animal; determination of the ratio of polychromatic/normochromatic erythrocytes - Control groups: negative (vehicle) control group and as positive control 7,12-dimethylbenz[a]anthracene (DMBA) treated with single dose of 0.5 mg Mitomycin C/kg i.p. STATISTICAL EVALUATION: Kastenbaum-Bowmann tables Reliability : (2) valid with restrictions individual animal data not given, no information on GLP and substance purity Flag : Critical study for SIDS endpoint 18.05.2004 (324) Type : Micronucleus assay Species : mouse Sex : male Strain : CD-1 Route of admin. : i.p. Exposure period : see freetext test conditions Doses : see freetext test conditions Result : negative Method : other: micronucleus assay in mouse bone marrow, see freetext TC Year : 1994 GLP : no data Test substance : other TS: o-toluidine, no data on purity Result : (1) single-treatment study: UNEP PUBLICATIONS 227
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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