o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 3. ENVIRONMENTAL FATE AND PATHWAYS ID: 95-53-4 DATE: 07.01.2005 78 - Derivatisation of free amines with trifluoroacetic anhydride - GC (Perkin Elmer F11, stainless steel capillary columns, several stationary phases) Result : o-Toluidine occurs in tocacco leaves Reliability : (2) valid with restrictions Basic data given Flag : Critical study for SIDS endpoint 24.02.2004 (44) Type of measurement : other: natural occurrence Media : food Concentration : Method : GC/MS Method : - Commercial blend of black tea was extracted with supercritical CO2 at 100-300 bars - Separation from CO2 at 50-70 bars to obtain aroma concentrate - Steam distillation of aroma concentrate - Fractionation in basic and neutral fraction - Direct injection of fraction into GC - GC (Carlo Erba GI Model 450, glass capillary column coated with polypropylene glycol) - GC coupled to MS Result : o-Toluidine occurs in the aroma of black teas Reliability : (2) valid with restrictions Basic data given Flag : Critical study for SIDS endpoint 24.02.2004 (45) Type of measurement : concentration at contaminated site Media : ground water Concentration : Method : reverse phase HPLC Method : In the environment o-toluidine is formed by reduction of o-nitrotoluene, e.g. at former munitions sites. Study was performed to elucidate the role of the manganese peroxidase (MnP) from white-rot fungi (species not reported). An abiotic system consisting of Mn(III) in oxalate buffer under aerobic conditions (Mn(II)/oxalate/O2) was used to transform 2-amino-4,6dinitrotoluene and its derivatives (including o-toluidine). Remark : Situation at former munitions sites is briefly described Result : o-Toluidine was degraded much faster than its precursor, o-nitrotoluene Test condition : - 50 µM (5.35 mg/l) of the test substance were incubated for 96 h at 20 °C in a system containing oxalate and Mn(III), under aerobic conditions - The reaction mixture was sterilized - pH rose from 4.5 to 7.5-8.0 over the time of the experiment - Quantitative determination of nitroaromatic compounds by reversed phase HPLC Reliability : (2) valid with restrictions Basic data given Flag : Critical study for SIDS endpoint 20.06.2004 (46) Type of measurement : other: concentration in fuel Media : other: coal oil Concentration : Method : GC/MS Method : - Acidic extraction - Gel chromatography for purification - Derivatisation with trifluoroacetic anhydride UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 3. ENVIRONMENTAL FATE AND PATHWAYS ID: 95-53-4 DATE: 07.01.2005 - GC/MS Result : Toluidine (isomers not specified, but o-toluidine likely to be present) was detected as a component of coal oil at a concentration of 135 mg/kg. Toluidine was not present in the 3 gasifier tars investigated. Reliability : (2) valid with restrictions Flag : Critical study for SIDS endpoint 07.06.2004 (47) Type of measurement : other: concentration in fuel Media : other: gasolines and aqueous extracts of gasolines Concentration : Method : HPLC/UV and HPLC/MS Result : o-Toludine is present in 77 % of [in total] 62 Swiss and 3 US gasoline samples (average 6.1 mg/l) and in their aqueous extracts (average 0.47 mg/l) Reliability : (2) valid with restrictions Basic data given Flag : Critical study for SIDS endpoint 20.06.2004 (25) Type of measurement : background concentration Media : surface water Concentration : Method : GC quantification, MS identification Result : o-Toluidine was found in 3 of of 9 samples. The highest value occurred in the river Alster (ca. 1 µg/l). Test condition : - 9 samples of environmental waters in Northern Germany - Fresh samples were anaylsed - GC quantification after derivatisation with trifluoroacetic acid anhydride - MS identification Reliability : (2) valid with restrictions Basic data given Flag : Critical study for SIDS endpoint 24.02.2004 (43) Type of measurement : background concentration Media : surface water Concentration : Method : GC, photometry Method : - GC according to 1980 publication of the authors - Colorimetric determination of total amines content as azo compounds by coupling with N-(1-naphthyl)-ethylenediamine. Absorbance was read at 555 nm. Practical limit of detectability 0.02-0.5 µg/l - Sampling in 1979, water including sediments Remark : In the Netherlands o-toluidin was measured in the river Rhine and in two of it's tributaries in 1979; GC-analysis, detection limit: 0.02 ug/l Result : o-Toluidine concentrations in the river Rhine and it´s tributaries: samples TS detected Concentration [ug/l] taken [%] Mean Max Rhine (Lobith)* 46 6 0.03 1.8 Boven Merwede** 12 8 0.07 0.80 Ijssel** 13 8 0.20 2.4 * weekly sampling ** monthly sampling Reliability : (2) valid with restrictions Basic data given Flag : Critical study for SIDS endpoint 20.06.2004 (48) UNEP PUBLICATIONS 79
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 11. Comments:
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OECD SIDS o-TOLUIDINE and transitio
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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