o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
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OECD SIDS o-<strong>TOLUIDINE</strong><br />
4. ECOTOXICITY ID: <strong>95</strong>-<strong>53</strong>-4<br />
DATE: 07.01.2005<br />
124<br />
Recovery rates were always > 87 %<br />
EFFECTS<br />
21day LC50 > 100 mg/L<br />
21day NOEC = 12.5 mg/L<br />
21day LOEC = 25 mg/L<br />
CUMULATIVE NUMBER OF DEAD FISH AFTER 21 DAYS<br />
measured con- number of mortality<br />
centration (mg/L) dead fish %<br />
---------------------------------------------------------------<br />
control 0 0<br />
6.25 0 0<br />
12.5 0 0<br />
25.0 0 0<br />
50 0 0<br />
100 2 10<br />
---------------------------------------------------------------<br />
First symptoms appeared at 25 mg/l after 15 days (light body colour and<br />
reduced activity), wheras at 100 mg/l several symptoms were observed just<br />
after 2 days.<br />
MONITORING DATA<br />
water temperature: 23 - 24 °C<br />
dissolved oxygen: 7.6 - 8.3 mg/L<br />
(Saturated concentration at 20 °C is 8.84 mg/L)<br />
pH: 7.2 - 7.7<br />
Test condition : DILUTION WATER<br />
source: tap water, dechlorinated by activated carbon<br />
hardness: 30.0 mg/L as CaCO3<br />
pH: 6.9<br />
TEST SYSTEM<br />
concentration: 0 (control), 6.23, 12.5, 25, 50, and 100 mg/L<br />
water temperature: 24 +- 1 °C<br />
temperature, oxygen-content and pH were measured at 0, 4, 7, 11, 14, 18,<br />
21 days<br />
renewal of test solution continuously (flow-through system)<br />
number of replicate: 1<br />
number of fish per dose: 10<br />
photo period: 16h-8h light-dark cycle by room light<br />
test parameter: mortality, toxic behavior<br />
Analysis method: HPLC at 0, 3, 7, 14, 21 days<br />
Reliability : (1) valid without restriction<br />
GLP guideline study<br />
Flag : Critical study for SIDS endpoint<br />
15.11.2004 (126)<br />
4.5.2 CHRONIC TOXICITY TO AQUATIC INVERTEBRATES<br />
Species : Daphnia magna (Crustacea)<br />
Endpoint : other: reproduction rate<br />
Exposure period : 21 day(s)<br />
Unit : mg/l<br />
NOEC : .0126<br />
LOEC : .04<br />
EC50 : .0658<br />
Analytical monitoring : yes<br />
Method : OECD Guide-line 202, part 2 "Daphnia sp., Reproduction Test"<br />
Year : 1996<br />
GLP : yes<br />
<strong>UNEP</strong> PUBLICATIONS
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