o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 270 30,000 workers, including approximately 15,500 women, were estimated to be occupationally exposed to o-toluidine in 1981-1983. Occupations with the greatest potential for exposure to the compounds include dye and pigment makers. In the early 1980s concentrations in the air at a facility producing dyes and pigments ranged from 0.004 to 0.26 ppm (0.02-1.5 mg/m3). In area samples taken in the air at two coal liquification pilot facilities, the mean concentration of o-toluidine was
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 26) from about 1.2 µg/l to 2.8 µg/l, and in exposed workers (n = 42-43) from about 15 µg/l to 99 µg/l. Levels of o-toluidine hemoglobin adducts were 3.5 ng/g hemoglobin in unexposed workers and 41 ng/g hemoglobin in exposed workers (Ward et al., 1996). Reliability : (2) valid with restrictions Basic data given Flag : Critical study for SIDS endpoint 03.06.2004 (388) (391) Type of experience : other: Health record from industry and smoking Result : 45 workers from 3 chemical plants (presumably in Germany) were examined. The urinary o-toluidine concentrations were 0.4 µg/l in occupationally exposed non-smokers and 0.6 µg/l in smokers (difference not significant). However, there were significant increases in the urinary otoluidine levels in unexposed smokers (mean 1.7 µg/l, n = 8), compared to unexposed non-smokers (0.0 µg/l, n = 8). Reliability : (2) valid with restrictions Basic data given Flag : Critical study for SIDS endpoint 03.06.2004 (410) Type of experience : other: Human exposure to o-toluidine via azo dyes Result : An OSHA report from 1982 states (cited according to NTP, 2003): "Consumer exposure to o-toluidine may possibly occur from residues present in commercial dyes used on textiles." (NTP, 2003). In the EU, the use of azo dyes releasing o-toluidine on degradation, is not permitted for textiles and other consumer articles (EU , 1976,; 2002,; 2003). The same conclusion has been drawn by the IARC (2000). Reliability : (2) valid with restrictions Data from handbook or collection of data Flag : Critical study for SIDS endpoint 03.06.2004 (411) (412) (413) (41) (3) Type of experience : other: Biological monitoring (human milk) Remark : The authors explain their observation with the occurrence of aromatic amines in tobacco smoke and some foods. Exposure to (environmental) tobacco smoke not conclusively determined Result : In human milk from 7 smokers and 24 non-smokers, there were
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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