o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 198 when evaluating a test system. ---In the present work the compound with code no 41 is declared as otoluidine hydrochloride, whereas in an the overall summary of this program code no. 41 is declared as o-toluidine. METABOLIC ACTIVATION: S9 mix - liver homogenates from with Aroclor 1254 induced rats Reliability : (2) valid with restrictions Method-Evaluation, unclear use: o-toluidine or o-toluidine hydrochloride 15.07.2004 (152) (249) (250) (251) Type : Gene mutation in Saccharomyces cerevisiae System of testing : strain D3 Test concentration : 0, 0.8 % in DMSO Cycotoxic concentr. : >0.8 % Metabolic activation : with and without Result : negative Method : other: see freetext ME Year : 1979 GLP : no data Test substance : other TS: o-toluidine, no data on purity Method : Method: A suspension of S. cerevisiae D3 was incubated was incubated with otoluidine for 4 hours at 30°C on a roller drum S9-mix was prepared from rat livers pretreated with Aroclor 1254 appropriate positive and negative controls were included (no further information) Reliability : (4) not assignable results from positive controls not reported, no detailed results from the assay with TS reported purity of TS not mentioned 15.07.2004 (252) (253) Type : Yeast Cytogenetic assay System of testing : strain 197/2d; strain rad3, rad18, rad52, trp2 Test concentration : 100, 300, 500, 750 µg/ml Cycotoxic concentr. : no data Metabolic activation : with and without Result : positive Method : other: according Hollstein et al., 1979 Year : 1981 GLP : no data Test substance : other TS: see freetext TC Test condition : This study is part of a International Collaborative Program, published as: Evaluation of Short-Term Tests for Cancerogens Progress in Mutation Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981 CHEMICALS: 42 coded chemicals were investigated in short-term tests for cancerogenicity in different laboratories It should be suggested that only 100%-pure chemicals should be used when evaluating a test system. ---In the present work the compound with code no 41 is declared as otoluidine hydrochloride, whereas in an the overall summary of this program code no. 41 is declared as o-toluidine. UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 METABOLIC ACTIVATION: S9 mix - liver homogenates from with Aroclor 1254 induced rats Reliability : (2) valid with restrictions Method-Evaluation, unclear use: o-toluidine or o-toluidine hydrochloride 15.07.2004 (152) (254) Type : Yeast Cytogenetic assay System of testing : Saccharomyces cerevisiae PG-148, PG-154, PG-155, PG-166 Test concentration : 100, 1000 µg/ml Cycotoxic concentr. : no data Metabolic activation : with and without Result : negative Method : other: according Zimmerman, 1975 Year : 1981 GLP : no data Test substance : other TS: see freetext TC Test condition : This study is part of a International Collaborative Program, published as: Evaluation of Short-Term Tests for Cancerogens Progress in Mutation Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981 CHEMICALS: 42 coded chemicals were investigated in short-term tests for cancerogenicity in different laboratories It should be suggested that only 100%-pure chemicals should be used when evaluating a test system. ---In the present work the compound with code no 41 is declared as otoluidine hydrochloride, whereas in an the overall summary of this program code no. 41 is declared as o-toluidine. METABOLIC ACTIVATION: S9 mix - liver homogenates from with Aroclor 1254 induced rats Reliability : (2) valid with restrictions Method-Evaluation, unclear use: o-toluidine or o-toluidine hydrochloride 15.07.2004 (152) (247) Type : other: Gene mutation in Saccharomyces cerevisiae, different endpoints System of testing : Saccharomyces cerevisiae D 7 Test concentration : 0, 20, 100, 500, 2500 µg/ml in DMSO Cycotoxic concentr. : 2500 µg/ml Metabolic activation : with and without Result : negative Method : other: according Zimmermann (1975) Mutat. Res. 28, 381, see freetext ME Year : 1985 GLP : no data Test substance : other TS: o-toluidine, no data on purity Method : negative control: DMSO positive control: 4-nitroquinoline-N-oxide, Cyclophosphamid incubation time: 16 hours, S9-mix was prepared from rat livers induced with Aroclor1254 statistical methods: Williams` test Dunnett's test Result : o-Toluidine did not lead to an induction of genetic effects. A growth-inhibiting effect of the compound was observed at the concentrations of 100-2500 µg/ml (without activation) and 2500 µg/ml (with activation) respectively. the positive controls were functional UNEP PUBLICATIONS 199
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 11. Comments:
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OECD SIDS o-TOLUIDINE and transitio
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OECD SIDS o-TOLUIDINE 1.3 Physico-C
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OECD SIDS o-TOLUIDINE methylene-bis
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OECD SIDS o-TOLUIDINE Table 3 Photo
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OECD SIDS o-TOLUIDINE With adapted
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OECD SIDS o-TOLUIDINE 3.1.2 Acute T
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OECD SIDS o-TOLUIDINE 3.1.4 Sensiti
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OECD SIDS o-TOLUIDINE Inhalation Th
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OECD SIDS o-TOLUIDINE Conclusion Th
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OECD SIDS o-TOLUIDINE 4.2 Terrestri
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OECD SIDS o-TOLUIDINE 6 REFERENCES
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OECD SIDS o-TOLUIDINE Bringmann G,
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OECD SIDS o-TOLUIDINE Hecht SS, El-
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OECD SIDS o-TOLUIDINE phase extract
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OECD SIDS o-TOLUIDINE Stark M (1892
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OECD SIDS o-TOLUIDINE I U C L I D D
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OECD SIDS o-TOLUIDINE 1. GENERAL IN
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OECD SIDS o-TOLUIDINE 5. TOXICITY I
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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